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531.
Assini FL Zanette KD Brocardo PS Pandolfo P Rodrigues AL Takahashi RN 《Environmental toxicology and pharmacology》2005,20(3):443-449
Organophosphorus compounds such as malathion are environmental contaminants that may evoke neurobehavioral responses including anxiety and depression. In this study, after a functional observational battery, rats were tested in an open field and temperature test to better define doses used in subsequent experiments. Then, we investigated the effects of acute and repeated treatment with malathion on elevated plus-maze and forced-swim test, which are validated animal models to observe for anxiety- and depressive-related behaviors, respectively. We found that both acute and repeated malathion administration induced anxiogenic and depressive-like responses at doses that affected neither locomotion nor systemic temperature. Biochemical assays demonstrated inhibition of cholinesterase activity by these effective doses. 相似文献
532.
Alessandro D. Loguercio Jovani Raffo Fabrício Bassani Heloiza Balestrini Dalvan Santo Roberto César do Amaral Alessandra Reis 《Clinical oral investigations》2011,15(4):589-596
The aim of this clinical trial was to evaluate the effects of application mode on the clinical performance of a two-step etch-and-rinse adhesive in class V cavities over 24 months. Forty patients with at least three similar-sized non-carious cervical lesions participated in this study. A total of 120 restorations with Prime & Bond NT were placed, 40 in each group. The adhesive was applied with no rubbing action, with slight rubbing action, or with vigorous rubbing action. The restorations were placed incrementally using the composite resin Esthet-X. The restorations were evaluated at baseline and after 6, 12, and 24 months following the modified United States Public Health Service criteria. Statistical analysis was conducted using Friedman repeated measures analysis of variance by rank and using the Wilcoxon signed-rank test for significance at each pair (α = 0.05). The 24-month retention rates of Prime & Bond NT were 82.5% for the no rubbing group, 82.5% for the slight rubbing group, and 92.5% for vigorous rubbing group. No significant difference in the retention rates in each recall period was detected among groups (p > 0.05); however, the retention rates in the 24-month recall was statistically lower than the baseline only for no rubbing or slight rubbing groups. The use of a vigorous application mode can be a clinical approach to improve the retention of restorations placed in non-carious cervical lesions. 相似文献
533.
de Borba Fabrício Castro Querin Giorgia França Marcondes Cavalcante Pradat Pierre-François 《Journal of neurology》2020,267(9):2625-2631
Journal of Neurology - Spinal muscular atrophy (SMA) is a genetic motor neuron disease related to deletions in the SMN1 gene. There is mounting evidence that the disease is not restricted to motor... 相似文献
534.