全文获取类型
收费全文 | 15772篇 |
免费 | 1900篇 |
国内免费 | 1175篇 |
专业分类
耳鼻咽喉 | 111篇 |
儿科学 | 222篇 |
妇产科学 | 161篇 |
基础医学 | 1500篇 |
口腔科学 | 257篇 |
临床医学 | 2026篇 |
内科学 | 2124篇 |
皮肤病学 | 161篇 |
神经病学 | 729篇 |
特种医学 | 613篇 |
外国民族医学 | 3篇 |
外科学 | 1419篇 |
综合类 | 3162篇 |
现状与发展 | 10篇 |
一般理论 | 2篇 |
预防医学 | 1485篇 |
眼科学 | 387篇 |
药学 | 1984篇 |
23篇 | |
中国医学 | 1310篇 |
肿瘤学 | 1158篇 |
出版年
2024年 | 116篇 |
2023年 | 350篇 |
2022年 | 828篇 |
2021年 | 1044篇 |
2020年 | 867篇 |
2019年 | 665篇 |
2018年 | 640篇 |
2017年 | 627篇 |
2016年 | 564篇 |
2015年 | 808篇 |
2014年 | 995篇 |
2013年 | 1011篇 |
2012年 | 1423篇 |
2011年 | 1500篇 |
2010年 | 1093篇 |
2009年 | 892篇 |
2008年 | 936篇 |
2007年 | 750篇 |
2006年 | 732篇 |
2005年 | 596篇 |
2004年 | 451篇 |
2003年 | 420篇 |
2002年 | 366篇 |
2001年 | 288篇 |
2000年 | 202篇 |
1999年 | 156篇 |
1998年 | 107篇 |
1997年 | 94篇 |
1996年 | 63篇 |
1995年 | 48篇 |
1994年 | 40篇 |
1993年 | 42篇 |
1992年 | 26篇 |
1991年 | 22篇 |
1990年 | 9篇 |
1989年 | 8篇 |
1988年 | 7篇 |
1987年 | 14篇 |
1986年 | 6篇 |
1985年 | 8篇 |
1984年 | 5篇 |
1983年 | 3篇 |
1982年 | 9篇 |
1981年 | 3篇 |
1980年 | 2篇 |
1978年 | 2篇 |
1949年 | 1篇 |
1938年 | 2篇 |
1928年 | 1篇 |
1924年 | 1篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
111.
Objective To analyze the outcomes of preoperative intracavitary brachytherapy plus sur-gery in patients with stage ⅠB2 and ⅡA bulky cervical cancer. Methods From January 2001 to January 2007, 77 patients with stage ⅠB2 and ⅡA bulky cervical cancer were included. The diameter of primary tumor was greater than 4 cm. Preoperative intracavitary brachytherapy with the total dose of 20-30 Gy (0.5 cm below the vaginal mucosa) was delivered by 2-3 fractions, one fraction per week. After an interval of 10-14 days, the efficacies of radiotherapy were evaluated and radical hysterectomy with pelvic lymphade-nectomy was performed. Then the treatment complications, clinicopathological characteristics, survival and recurrence were analyzed. Results The tumor shrinkage was observed in all the patients after intracavitary brachytherapy. The CR, PR and SD were 5% (4/77), 36% (28/77) and 58% (45/77), respectively. Radical hysterectomy was successfully performed in all patients. The complications of the combined therapy were mild and only 5 patients had grade Ⅱ or less hematological or gastrointestinal toxicities. The 5-year o-verall survival rate and pelvic recurrence rate were 83% and 12%, respectively. Conclusions Preoperative intracavitary brachytherapy of 20-30 Gy plus surgery is effective in the treatment of stage ⅠB2 and ⅡA bulky cervical cancer without increasing the treatment complications. 相似文献
112.
内抑素(endostatin)对移植大肠癌新生血管密度影响的动物实验研究 总被引:1,自引:0,他引:1
目的:探讨内皮细胞生长抑素(内抑素endostatin)对裸鼠大肠血管生成的影响及其作用机理,为endostatin的临床应用提供理论依据。方法:采用免疫组化方法检测肿瘤新生血管密度,对用药过程中瘤 体积进行测量,对endostatin抑制肿瘤的效果进行分析。结果:endostatin能够抑制裸鼠大肠癌肿瘤血管生成,减轻肿瘤的血管密度。结论:endostatin通过抑制血管形成抑制肿瘤的生长。 相似文献
113.
114.
中药银杏叶提取物治疗冠心病心绞痛的临床研究 总被引:13,自引:0,他引:13
中药银杏叶提取物的主要成分是总黄酮与内脂。我们使用4家药厂制作的3种制剂(含量相等)来治疗冠心病心绞痛,通过观察346例患者服药4周后心绞痛的发作变化,加用相关药物的减停情况,以及心电图ST变化等指标,综合评估银杏叶提取物的临床疗效。结果:其症状总有效率为91.33%,心电图总有效率为73.99%,未见毒副反应。说明银杏叶提取物对心绞痛有良效。 相似文献
115.
116.
Salbutamol or mist in acute bronchiolitis 总被引:1,自引:0,他引:1
Demet Can GÜLten Nan GÜRol Yendur Resmiye Oral Lker GÜNay 《Pediatrics international》1998,40(3):252-255
Abstract Background : The role of bronchodilators in the treatment of bronchiolitis remains controversial.
Methods : A double-blind, placebo controlled trial was performed to evaluate the clinical response to nebulized salbutamol. One hundred and fifty-six infants aged between 7 weeks and 24 months who had had an episode of wheezing and other signs and symptoms of bronchiolitis were randomized to three groups as follows: (i) nebulized salbutamol was administered to 52 patients in group I at a dose of 0.15 mg/kg in 2 mL saline; (ii) saline was nebulized to 52 patients in group II and (iii) in group III 52 patients received mist in a tent. All three groups were administered oxygen during the procedures. Treatment was repeated with the same agent after 30 min if the respiratory score was 5 or more. Respiratory rate, heart rate, oxygen saturation and presence of cyanosis, wheezing, retractions were recorded before and after each treatment.
Results : The decrease in the respiratory score was 5.2 ± 1.8, 0.82 ± 2.4 and 1.7 ± 1.3 in group I, II and III, respectively. The decrease in group I was significantly higher than in the other groups. Heart rate was similar between groups. Oxygen saturation decreased in group I without reaching statistical significance.
Conclusions: Salbutamol was shown to be effective and safe in the treatment of acute bronchiolitis. 相似文献
Methods : A double-blind, placebo controlled trial was performed to evaluate the clinical response to nebulized salbutamol. One hundred and fifty-six infants aged between 7 weeks and 24 months who had had an episode of wheezing and other signs and symptoms of bronchiolitis were randomized to three groups as follows: (i) nebulized salbutamol was administered to 52 patients in group I at a dose of 0.15 mg/kg in 2 mL saline; (ii) saline was nebulized to 52 patients in group II and (iii) in group III 52 patients received mist in a tent. All three groups were administered oxygen during the procedures. Treatment was repeated with the same agent after 30 min if the respiratory score was 5 or more. Respiratory rate, heart rate, oxygen saturation and presence of cyanosis, wheezing, retractions were recorded before and after each treatment.
Results : The decrease in the respiratory score was 5.2 ± 1.8, 0.82 ± 2.4 and 1.7 ± 1.3 in group I, II and III, respectively. The decrease in group I was significantly higher than in the other groups. Heart rate was similar between groups. Oxygen saturation decreased in group I without reaching statistical significance.
Conclusions: Salbutamol was shown to be effective and safe in the treatment of acute bronchiolitis. 相似文献
117.
118.
目的:研究血压平逆转二肾一夹肾性高血压大鼠左室重构的作用及其机理。方法:建立2K1C肾性高血压大鼠(RHR)模型,术后8周40只RHR随机分为5组,每组8只,分为:血压平大、中、小剂量组(73、36.5、18.25g·kg-1·d-1);依那普利组(10g·kg-1·d-1);模型组,另取8只大鼠作为假手术对照组。模型组和假手术组灌服等容量水,疗程8周。手术前及术后每周测血压1次,给药第8周末,各组测量大鼠体重(BW),眼眶放血2ml,断头处死大鼠,迅速取出心脏,去除心房、右室游离壁,左室及室间隔称重(LVW),计算LVW/BW之比。采用放免法检测血清PCⅢ,心肌组织石蜡切片HE染色及SP免疫组化染色高清晰度图像分析系统测量心肌细胞形态参数及原癌基因cmyc和cfos表达阳性细胞的平均光密度值。结果:血压平降低血压,降低左室重量(LVW)、左室重量指数(LVW/BW)、心肌细胞体积及血清PCⅢ含量,抑制原癌基因cmyc和cfos的表达,血压平大、中剂量组LVW、LVW/BW及血清PCⅢ含量明显低于模型组(P<0.01),图像分析心肌细胞形态参数(面积、周长、平均直径、长径及短径)及cmyc、cfos表达阳性的心肌细胞平均光密度值明显低于模型组(P<0.01),与假手术组接近(P>0.05)。结论:复方中药血压平具有逆转2K1C肾性高血压大鼠左室重构的作用,其降低血压和血清PCⅢ含量、抑制Ⅲ型胶原合成、防治心肌纤维化及降低原癌基因cmyc和cfos的表达、抑制心肌细胞肥大、减轻左心室肥厚是其逆转二肾一夹肾性高血压大鼠左室重构的部分机制。 相似文献
119.
羟基喜树碱腹腔内给药的药代动力学研究 总被引:2,自引:0,他引:2
目的:研究羟基喜树碱(HCPT)腹腔内给药的药代动力学特点。方法:比格犬6只,HCPT剂量2 mg.kg-1,溶于50 mL生理盐水中,先腹腔内注入250 mL生理盐水,随后用恒速泵快速注入HCPT;随后按不同时间点抽取血液和腹腔液,各样本用高效液相色谱分析药物浓度,并用3p87软件包计算药代动力学参数。结果:腹腔液HCPT的AUC与外周静脉血及门静脉血AUC之间的比值分别为45∶1和37∶1,P值均小于0.001;腹腔液HCPT浓度明显高于外周静脉给药组的腹腔液浓度,峰值为60.4倍,AUC为21倍。P值均小于0.001。结论:腹腔内给药其药代动力学具有明显优越性,能维持腹腔液和门静脉血更高更持久的血药浓度,因而有利于化疗药物发挥更大的生物学效应,值得临床应用。 相似文献
120.
重组色素上皮细胞衍生因子抑制鸡胚绒毛尿囊膜血管及兔角膜新生血管 总被引:1,自引:1,他引:1
目的:观察制备的重组色素上皮细胞衍生因子(rPEDF)对鸡胚绒毛尿囊膜(CAM)血管及兔角膜新生血管的抑制作用。方法:制备rPEDF,采用鸡胚绒毛尿囊膜分析,观察rPEDF抑制新生血管生长情况。利用碱烧伤制作兔角膜新生血管模型,观察rPEDF抑制角膜新生血管生长状况。结果:rPEDF能明显抑制鸡胚绒毛尿囊膜血管生长。rPEDF治疗组兔角膜新生血管长度及生长面积明显少于对照组(P<0.05),差异有统计学意义。结论:制备的rPEDF抑制鸡胚绒毛尿囊膜血管生长,抑制兔角膜新生血管的形成。 相似文献