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No national epidemiological investigations have been conducted recently regarding facial lacerations. The study was performed using the data of 3,634,229 people during the 5-year period from 2014 to 2018 archived by the National Health Information Database (NHID) of the Health Insurance Review and Assessment Service. Preschool and children under 10 years old accounted for about one-third of patients. Facial lacerations were concentrated in the “T-shaped” area, which comprised forehead, nose, lips, and the perioral area. The male to female ratio for all study subjects was 2.16:1. Age and gender are significantly related with each other (P < .001). Mean hospital stays decreased, and numbers of outpatient department visits per patient were highest for hospitals and lowest for health agencies. Over the study period, hospital costs per patient in tertiary and general hospitals increased gradually. Preschool and school-aged children are vulnerable to trauma. Male patients outnumbered female patients by a factor of more than 2. The “T-shaped’” area around forehead is vulnerable to injury. Total cost of medical care benefits per patient in tertiary hospitals was about 7 times on average than in health agencies. Regarding functional, behavioral, and aesthetic outcomes, more attention should be paid to epidemiologic data and hospital costs for facial lacerations. 相似文献
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Discoid lupus erythematosus (DLE) is the most common skin manifestation of lupus; however, the molecular mechanisms underlying DLE remain unknown. Therefore, we aimed to identify key differentially expressed genes (DEGs) in discoid lupus skin and investigate their potential pathways.To identify candidate genes involved in the occurrence and development of the disease, we downloaded the microarray datasets and GSE52471 from the Gene Expression Database (GEO). DEGs between discoid lupus skin and normal controls were selected using the GEO2R tool and Venn diagram software ( GSE72535http://bioinformatics.psb.ugent.be/webtools/Venn/). The Database for Annotation, Visualization, and Integrated Discovery (DAVID), Enrichr, and Cytoscape ClueGo were used to analyze the Kyoto Encyclopedia of Gene and Genome pathways and gene ontology. Protein-protein interactions (PPIs) of these DEGs were further assessed using the Search Tool for the Retrieval Interacting Genes version 10.0.Seventy three DEGs were co-expressed in both datasets. DEGs were predominantly upregulated in receptor signaling pathways of the immune response. In the PPI network, 69 upregulated genes were selected. Furthermore, 4 genes (CXCL10, ISG15, IFIH1, and IRF7) were found to be significantly upregulated in the RIG-I-like receptor signaling pathway, from analysis of Enrichr and Cytoscape ClueGo.The results of this study may provide new insights into the potential molecular mechanisms of DLE. However, further experimentation is required to confirm these findings. 相似文献
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Jae Hwang Song Chan Kang Deuk Soo Hwang Dong Hun Kang Yong Hwan Kim 《Foot and Ankle Surgery》2019,25(6):748-754
BackgroundThe purpose of this study was to investigate and compare the clinical outcomes of dorsal suspension with those of neurectomy for the treatment of Morton’s neuroma.MethodsWe conducted a retrospective study of dorsal suspension and neurectomy group. The dorsal suspension was performed by dorsal transposition of neuroma over the dorsal transverse ligament after neurolysis. The visual analog scale (VAS), the Foot and Ankle Ability Measure (FAAM), postoperative satisfaction, and complications were evaluated.ResultsBoth groups reported significant pain relief, and there were no significant differences between the groups with respect to postoperative pain. The postoperative FAAM outcomes showed no significant between-group differences. Satisfaction analysis showed ‘excellent’ and ‘good’ results in the dorsal suspension and neurectomy groups (95% and 77.7%, respectively). Complications of numbness and paresthesia reported in the dorsal suspension group (5% and 5%, respectively) were significantly fewer than those of neurectomy group (61.1% and 33.3%, respectively) (both, p < .05).ConclusionsWith its favorable results, dorsal suspension can be another operative option for the treatment of Morton’s neuroma.Level of Evidence: Level III, retrospective comparative case series. 相似文献
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表观遗传修饰异常与肿瘤发生发展密切相关,其中非编码RNA是三种常见的表遗传修饰方式之一,而环状RNA(circular RNA,circRNA)作为一类具有闭合环状结构的非编码RNA分子,研究证实可作为miRNA的海绵起调控作用,参与肿瘤细胞增殖、分化、凋亡、侵袭、转移等多种病理生理调控。同时circRNA具有特异性表达、高度保守和高稳定性等特点,因此circRNA相关标志物可能成为肿瘤早期诊断、治疗以及预后评估的有效标志物,也为肿瘤诊疗提供了无创检测的新契机。本文主要阐述circRNA相关标志物在肿瘤中的研究进展及应用现状,并探讨其在肿瘤表观遗传学中的机遇和挑战。 相似文献
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Parallel enzyme‐linked immunosorbent assay screening for human immunodeficiency virus among blood donors in five Chinese blood centres: a retrospective analysis 下载免费PDF全文
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目的 观察“龙虎交战”针法针刺八脉交会穴对无先兆偏头痛(Migraine without aura,MO)患者头痛天数及外周血降钙素基因相关肽(Calcitonin gene related peptide,CGRP)表达水平的影响。方法 按照头痛程度将90例MO受试者区层随机分为治疗Ⅰ组、治疗Ⅱ组和对照组各30例。治疗Ⅰ组施以“龙虎交战”针法针刺八脉交会穴(外关和足临泣),治疗Ⅱ组施以平补平泻针法针刺八脉交会穴(外关和足临泣),对照组施以平补平泻针法针刺非经非穴点,每次留针30分钟,5次/周,共治疗20次。于治疗前、治疗结束4周后的随访分别记录三组患者头痛天数的变化情况以判定疗效,并采集患者治疗前、治疗结束4周后随访的肘部静脉血用ELISA法检测血清中的CGRP含量的变化。结果 ①各组治疗前患者的头痛天数无显著差异(P > 0.05),治疗Ⅰ组、治疗Ⅱ组和对照组治疗结束4周后随访的头痛天数较治疗前均显著降低(P < 0.05);治疗Ⅰ组头痛天数的降低显著优于治疗Ⅱ组和对照组(P < 0.001),治疗Ⅱ组头痛天数的降低显著优于对照组(P < 0.05);②3组治疗前CGRP的表达无显著差异,治疗Ⅰ组、治疗Ⅱ组治疗结束4周后随访CGRP的表达较治疗前均显著下降(P < 0.001),对照组治疗结束4周后随访CGRP的表达较治疗前差异无显著性(P > 0.05);治疗Ⅰ组CGRP治疗结束4周随访的表达较治疗Ⅱ组和对照组均显著下降(P < 0.01),治疗Ⅱ组CGRP的表达较对照组显著下降(P < 0.01)。结论 ①八脉交会穴施以“龙虎交战”针法针刺能明显改善MO患者的头痛天数,同时降低MO患者血清CGRP的表达水平,这可能是针刺八脉交会穴治疗MO的机制之一;②非经非穴点的针刺效应无持续性,而八脉交会穴的针刺效应具有持续性;③八脉交会穴可以充分发挥复式针刺手法的治疗效应,提示我们在临床上治疗疾病时不仅要注意腧穴配伍,恰当的针刺手法更是提高临床疗效、事半功倍的关键。 相似文献
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Clinical usefulness of intraductal ultrasonography for the management of acute biliary pancreatitis 下载免费PDF全文