局部亚低温治疗急性脑出血的临床研究

目的观察冰帽加双侧颈动脉区冰敷治疗急性脑出血的临床疗效和探讨最佳治疗时机。方法 174例急性脑出血患者随机分为治疗组和对照组 ,每组 87例。对照组给予常规治疗 ,治疗组在常规治疗的基础上同时给予亚低温治疗 ;治疗组中 46例在发病 3小时内治疗 ,41例在发病 3小时后治疗。观察治疗组与对照组以及治疗组中发病 3小时内与发病 3小时后两组的临床疗效和预后情况。结果亚低温治疗组与对照组比较 ,神经功能改善 (P <0 0 5 ) ,生存率及恢复良好率提高 (P <0 0 5 )。发病 3小时内开始治疗者优于 3小时后开始者 (P <0 0 5 )。结论亚低温治疗能有效减轻急性脑出血后的神经功能缺损 ,降低病死率和致残率 ;最佳治疗时机在发病 3小时以内。     

急性脑血管病与代谢紊乱的关系

目的　探讨急性脑血管病与代谢紊乱的关系。方法　对 2 72名上海地区正常人及 92 3例急性脑血管病 (5 0 3例脑梗死、4 2 0例脑出血 )患者住院的基线资料进行分析。结果　① 5 0 3例脑梗死、4 2 0例脑出血患者的年龄、体重指数 (BMI)、血压、血糖、低密度脂蛋白 (LDL)值均高于对照组 (P <0 .0 5 )。②脑梗死、脑出血患者中 ,伴高血压者分别为 95 .0 %、97.1% ;伴高血糖者分别为 4 4 .0 %、39.7% ;伴高三酰甘油 (TG) /低高密度脂蛋白 (HDL)分别为 34.8%、38.1% ;③脑梗死、脑出血患者中 ,合并代谢综合征者分别占 14 .7%、16 .7% ;合并 2种代谢紊乱者分别占 4 6 .9%、4 3.1% ;合并 1种代谢紊乱者分别占 36 .0 %、38.8% ;无代谢紊乱者仅分别占2 .4 %、1.4 %。④脑梗死、脑出血患者中 ,除代谢紊乱者血压均显著高于对照组及无代谢紊乱者外 ,合并 2种以上代谢紊乱患者中BMI、血糖、TG均高于对照组及无代谢紊乱者 (P <0 .0 5 )。结论　急性脑血管病患者多伴有多种代谢紊乱 ,因而 ,有效控制代谢紊乱与预防脑血管病的发生、发展及其预后有关     

超声检查在男性创伤性尿道狭窄诊断中的价值

目的探讨超声检查对男性创伤性尿道狭窄的诊断价值。方法对21例男性创伤性尿道狭窄患者进行超声检查,14例同时联合尿道造影检查,结果与术中所见进行对比分析。结果21例超声结果与术中所见一致。14例联合检查中,造影检查有2例前尿道狭窄漏诊,2例狭窄近侧结石未发现,2例正常后尿道误诊为狭窄,2例后尿道狭窄长度不能估计;2例会阴部瘘管造影清晰显示而超声显示不佳。结论超声在狭窄定位、长度测量、瘢痕范围估测及显示继发结石等方面优于造影,造影显示瘘管清晰,必要时两者应联合应用。     

Reactivity of hydroxybenzoic acids in the hydrogen-isotope exchange reaction.

The hydrogen-isotope exchange reaction (T-for-H exchange reaction) between tritiated water vapor (HTO vapor) and 3-hydroxy-4-methoxybenzoic acid (and it's analog; 4-hydroxy-3-methoxybenzoic acid) were observed at 50 and 70 degrees C in a gas-solid system to reveal the reactivity of a functional group in an aromatic compound having two substituents in the aromatic ring. Further, it was shown that (a) the reactivity of the compounds used in this work follows the Hammett's rule, and (b) the reactivity of trisubstituted aromatic compound could be analyzed by applying the additive property of the Hammett's rule even if the compound contains a substituent at the ortho-position.     

氮芥抗药性人早幼粒白血病HL60细胞亚系的建立及其生物特性

用逐步递增药物浓度和软琼脂细胞克隆技术，药物连续作用１４个月后获得氮芥（ＨＮ２）抗药性人早幼粒白血病ＨＬ６０细胞亚系，抗件达５～７倍（ＨＬ６０／ＮＨ２６），在无ＨＮ２培养液中５倍以上抗性维持１０个月以上，抗性细胞亚系的生物学特性除倍增时间稍长和克隆形成率略低外其生长曲线，细胞周期细胞ＤＮＡ指数，形态学，组织化学和染色体分析均与亲代细胞相似。     

基于网络环境下的教学设备管理信息系统

本文介绍了教学设备网络管理系统模型及其技术指标、软硬件环境、功能、程序设计和主要特点。     

The effect of vascular endothelial growth factor on the healing of ischaemic skin wounds.

The effect of exogenous vascular endothelium growth factor (VEGF) on wound healing in an ischaemic skin flap model was evaluated in this study. Seventy-two Sprague-Dawley rats were used. Normal incisional wound and H-shaped double flaps were used as the wound models. The study was divided into two parts. In Part I, VEGF protein levels were determined from the incisional and H-shaped ischaemic wounds at 12 and 24 h, postoperatively. In Part II, tensile strength and immunohistochemical stains were examined to determine the level of microvessel density (MVD) at 1 and 2 weeks, postoperatively in simple incisional wounds, ischaemic wounds, and ischaemic wounds following 1 ml (1 microg/ml) exogenous VEGF injections into the subcutaneous tissue. The results showed a significantly higher level of VEGF protein in the ischaemic wounds than the incisional wounds. Tensile strength was statistically higher in the incisional wound group and in the ischaemic flap wounds with VEGF treatment compared to the ischaemic flaps with no treatment at 1 week, postoperatively (p>0.05). MVD data indicated that ischaemic wound repair with VEGF treatment had significantly higher MVD than the normal incisional wounds and ischaemic wounds without treatment. We conclude that exogenous application of VEGF can increase early angiogenesis and tensile strength in the ischaemic wound.     

改进时间差攻击疗法治疗多重耐药阴沟肠杆菌的探究

[目的]研究利用改进的时间攻击疗法治疗多重耐药阴沟肠杆菌引起的感染的效果，并考究其与亚胺培南/西拉司丁治疗及传统时间攻击疗法的药物经济学成本/效果比。[方法]将38例明确诊断为产ESBLs阴沟肠杆菌感染且药敏结果皆为：对哌拉西林、环丙沙星、氧氟沙星、左旋氧氟沙星、庆大霉素、妥布霉素、头孢他啶、头孢噻肟、头孢哌酮、头孢曲松、头孢哌酮/舒巴坦、替卡西林/克拉维酸等皆耐药，而对亚胺培南/西拉司丁敏感的患者随机分为改进组、对照组、传统组。改进组患者先与磷霉素4g＋5%葡萄糖100ml于30min静脉滴注完毕后，再过30min立即给予阿米卡星0.4g＋0.9%NS250ml静脉滴注，上述治疗每日1次。对照组患者给予亚胺培南/西拉司丁1g＋0.9%NS250ml静脉滴注，每日3次。传统组患者先与磷霉素2g＋5%葡萄糖50ml静脉给予1h完毕后，立即给予阿米卡星0.2g＋0.9%NS100ml静脉滴注，上述治疗每日2次。疗程最长限为10d，其余检查治疗3组相同。考察3组的细菌清除率以及细菌清除所需的药物费用、不良反应的比较。[结果]改进组细菌清除率与对照组、传统组差异无统计学意义，并且改进组、传统组无不良反应，对照组有1例二重感染；而且改进组与对照组、传统组的细菌清除药物治疗费用差异有统计学意义。[结论]利用磷霉素＋阿米卡星的改进时间攻击差疗法能很好的治疗多重耐药的阴沟肠杆菌引起的感染，并且与采用亚胺培南/西拉司丁治疗方案及传统的时间攻击疗法相比具有较好的成本/效果比。     

Atypical fibroxanthoma and squamous cell carcinoma of the conjunctiva in xeroderma pigmentosum.

Patients with xeroderma pigmentosum (XP) have defective DNA repair and a high predisposition to developing abnormalities and neoplasia in the sun-exposed areas of the skin and mucous membranes. The most common tumors reported in patients with XP are squamous cell carcinomas, basal cell carcinomas, and melanomas. Atypical fibroxanthoma (AFX) is a pleomorphic tumor that arises predominantly in the sun-damaged skin of the head and neck regions of the elderly. We describe a unique case of a 6-year-old African American boy with XP who developed an atypical fibroxanthoma and 2 squamous cell carcinomas in the conjunctiva. The clinical and histopathologic findings of AFX are discussed.     

动脉顺应性及其影响因素

动脉顺应性又称动脉弹性，反映血管内皮功能。已成为预测心血管疾病的重要危险因素。无创测量动脉弹性的方法在临床上已有一定程度的应用。各种方法具有其各自适用范围及局限性。多种干预手段可以影响动脉弹性。合理测量及维持正常的动脉弹性可延缓多种心血管疾病的发生及发展。