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991.
Premalignant lesions and nonsquamous malignancy of the penis and carcinoma of the scrotum. 总被引:2,自引:0,他引:2
P F Schellhammer G H Jordan E L Robey J T Spaulding 《The Urologic clinics of North America》1992,19(1):131-142
Premalignant lesions of the penis include cutaneous horn, balanitis xerotica obliterans, and leukoplakia. The true incidence of progression of each of these to squamous-cell carcinoma is unknown. Bowenoid papulosis, erythroplasia of Queyrat, and Bowen's disease are histologically identical to in situ carcinoma. Although the first is consistently benign, the latter two regularly evolve into invasive cancer. Malignant scrotal lesions include squamous-cell carcinoma, liposarcoma, leiomyosarcoma, basal-cell carcinoma, extramammary Paget's disease, erythroplasia of Queyrat, malignant melanoma, and metastases. Hemangioma can be confused with carcinoma. 相似文献
992.
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995.
F. M. RAAPHORST R. LANGLOIS VAN DEN BERGH J. L. M. WAAIJER J. M. VOSSEN & M. J. D. VAN TOL 《Scandinavian journal of immunology》1997,46(3):292-297
Fetal B lymphocytes in mice and humans use a limited number of the available VH gene segments. Mouse fetal B cells primarily utilize 3' VH elements, suggesting that the localization of these elements determines their rearrangement frequency. The previously reported non-random usage of human VH genes has been more difficult to explain. In this study the authors analysed the expression of the most proximal 3' human VH element (VH 6) using a monoclonal antibody (JE-6). VH 6 expression was assessed in various B cell differentiation stages from fetal liver, bone marrow and spleen at 12–20 weeks of gestation. The authors demonstrate that the level of VH 6 expression does not exceed a stochastic usage frequency. This suggests that the localization of VH 6 does not significantly promote its expression during human fetal life, and that other factors must affect the usage of VH genes during human fetal development. 相似文献
996.
结肠腺瘤与腺癌p53,c—erbB2蛋白及CEA的表达和意义 总被引:1,自引:0,他引:1
应用免疫组化法检测15例正常结肠粘膜,40例结肠瘤及40例结肠癌组织的p53,c-erbB2和CEA的表达。结果发现:结肠癌患者p53,c-erbB2及CEA的阳性表达率均显著高于腺瘤(P〈0.01)。p53阳性表达在不典型增生腺瘤患者中,重度显著高于轻度病例(P〈0.01);在结肠腺癌患者中低分化显著高于高分化病例(P〈0.05);CEA的新型单克隆抗体col-1对结肠癌的敏感性和特异性均高,阳 相似文献
997.
Spleen sizing by ultrasound in polycythaemia and thrombocythaemia: comparison with SPECT 总被引:3,自引:1,他引:2
M. Messinezy L. M. MacDonald T. O. Nunan N. B. Westwood S. Chinn & T. C. Pearson 《British journal of haematology》1997,98(1):103-107
Detection of non-palpable early splenic enlargement may aid diagnosis of primary polycythaemia (PP) and primary thrombocythaemia (PT). In this study linear spleen sizing by ultrasound has been compared with spleen volume estimation by single photon emission computerized tomography (SPECT) in 26 patients. Spleen length by ultrasound correlated well with SPECT volume estimation.
Ultrasound spleen length was also measured in 60 normal control subjects where the upper limit of the 95% reference range was 11.6 cm. Changes in spleen length with both age and body weight were substantial and overshadowed the imperfect reproducibility of this method. Therefore, interpretation of an individual's measured spleen length should be in relation to that predicted for adults of the same age and weight, particularly at the extremes of the younger, heavier patients and also the older, lighter patients.
Ultrasound spleen lengths of different patient groups (21 PP, 26 PT, 17 idiopathic erythrocytosis, 12 secondary polycythaemia, nine apparent polycythaemia) were compared both using the measured overall reference range and the differences from the values predicted for their age and weight. The comparison showed that almost all patients with PP whose spleens were not palpable had spleen lengths greater than the upper limit for the normal control group, but separation from the other patient groups was incomplete.
Detection of non-palpable splenomegaly by ultrasound length should remain a 'minor' criterion amongst the 'proposed modified diagnostic criteria' of PP. 相似文献
Ultrasound spleen length was also measured in 60 normal control subjects where the upper limit of the 95% reference range was 11.6 cm. Changes in spleen length with both age and body weight were substantial and overshadowed the imperfect reproducibility of this method. Therefore, interpretation of an individual's measured spleen length should be in relation to that predicted for adults of the same age and weight, particularly at the extremes of the younger, heavier patients and also the older, lighter patients.
Ultrasound spleen lengths of different patient groups (21 PP, 26 PT, 17 idiopathic erythrocytosis, 12 secondary polycythaemia, nine apparent polycythaemia) were compared both using the measured overall reference range and the differences from the values predicted for their age and weight. The comparison showed that almost all patients with PP whose spleens were not palpable had spleen lengths greater than the upper limit for the normal control group, but separation from the other patient groups was incomplete.
Detection of non-palpable splenomegaly by ultrasound length should remain a 'minor' criterion amongst the 'proposed modified diagnostic criteria' of PP. 相似文献
998.
999.
G. V. Petrova V. A. Adarichev A. A. Krivenko G. S. Dymshits A. L. Markel' G. S. Yakobson 《Bulletin of experimental biology and medicine》1997,124(2):773-775
Sensitivity of normotensive Wistar rats and NISAG rats (with hereditary arterial hypertension) to heat stress is compared
at the organism and cell levels. High temperature sensitivity of NISAG rats correlates with a low content of the main heat
shock protein HSP70. This relationship can serve as a biochemical marker of predisposition to arterial hypertension.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 124, No. 8, pp. 171–173, August, 1997 相似文献
1000.