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991.
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Jens Hoeppner Vladan Crnogorac Goran Marjanovic Eva Jüttner Tobias Keck Hans-Fred Weiser Ullrich Theodor Hopt 《International journal of colorectal disease》2009,24(5):543-550
Background Different materials have been evaluated for anastomotic reinforcement to prevent gastrointestinal anastomotic leakage. In
this experimental study, small intestinal submucosa (SIS) was tested as a sealing for stapled colonic anastomosis in a porcine
model. The aims of this study were to determine the macroscopic and microscopic outcomes and to evaluate the safety and feasibility
of applying SIS for anastomotic sealing.
Materials and methods Circular stapled anastomoses were performed in 18 pigs. Standard anastomosis in the control group (n = 8) was compared to an SIS-sealed anastomosis in the study group (n = 10). After 30 days, anastomotic segments were examined for macroscopic and microscopic regeneration and their resistance
to mechanical stress. Furthermore, animal survival and clinical course were evaluated.
Results None of the animals developed anastomotic leakage, intraabdominal abscess, or peritonitis. Shrinkage of SIS was evident in
nine of ten animals. Encapsulation and displacement of the SIS patches were seen in two animals. Quantity of anastomotic granulation
tissue and rate of complete mucosal coverage of anastomotic line were increased in SIS-sealed anastomoses without reaching
significance. Moreover, no significant differences were found in the rate of survival of the animals, anastomotic stricture
formation, intraabdominal adhesions, anastomotic bursting pressure, and microscopic healing parameters of the anastomosis
between stapled colonic standard anastomosis and anastomosis protected by SIS.
Conclusion The results of this study indicate a safe use of SIS for anastomotic reinforcement in a porcine model. Adverse effects like
strictures, increased adhesions, and anastomotic abscesses were absent. Promoting effects on colonic wound healing by SIS
were microscopically evident. The results argue for a careful clinical evaluation in humans. 相似文献
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995.
Matthias Thielmann Eva Kottenberg Kerstin Boengler Christoph Raffelsieper Markus Neuhaeuser Jürgen Peters Heinz Jakob Gerd Heusch 《Basic research in cardiology》2010,105(5):657-664
Remote ischemic preconditioning (RIPC) with transient upper limb ischemia reduces myocardial injury in patients undergoing
on-pump coronary artery bypass grafting (CABG) with cross-clamp fibrillation or blood cardioplegia for myocardial protection.
Whether or not such protection is still operative when standard crystalloid cardioplegic arrest is used is uncertain. Fifty-three
consecutive, non-diabetic patients with triple-vessel disease and 64 ± 12 years of age (mean ± SD), who underwent elective
CABG surgery with crystalloid (Bretschneider) cardioplegic arrest, were allocated in a prospective, randomized, single-blinded
protocol to receive either a RIPC protocol (3 cycles of 5 min transient left upper arm ischemia induced by inflating a blood
pressure cuff to 200 mmHg with 5 min of reperfusion) or control, respectively, after induction of anesthesia. Cardiac troponin
I (cTnI) concentration was measured preoperatively and over 72 h postoperatively, and the area under the curve (AUC) was calculated.
Peak postoperative cTnI concentration was significantly reduced from 13.7 ± 7.7 ng/mL in controls to 8.9 ± 4.4 ng/mL in RIPC
(P = 0.008). Mean cTnI concentration was significantly lower at 6, 12, 24, and 48 h after surgery (ANOVA; P < 0.0001) in the RIPC patients (N = 27) than in controls (N = 26), resulting in a 44.5% reduction of cTnI (AUC at 72 h). RIPC by repetitive inflation of a cuff around the left upper
arm before surgery enhances myocardial protection in patients undergoing CABG surgery with antegrade cold crystalloid cardioplegia. 相似文献
996.
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999.
Melissa B. Aldrich XueJuan Wang Amy Hart Sunkuk Kwon Lakshmi Sampath Milton V. Marshall Eva M. Sevick-Muraca 《Molecular imaging and biology》2011,13(1):32-42
Purpose
Recent preclinical and clinical studies show that dyes that excite and fluoresce in the near-infrared range may be used for tracking and detecting disease targets in vivo. A method for quantifying free dye molecules in antibody conjugate preparations is required for agent batch release and for translation into the clinic. 相似文献1000.