全文获取类型
收费全文 | 3573篇 |
免费 | 196篇 |
国内免费 | 16篇 |
专业分类
耳鼻咽喉 | 9篇 |
儿科学 | 110篇 |
妇产科学 | 116篇 |
基础医学 | 492篇 |
口腔科学 | 30篇 |
临床医学 | 331篇 |
内科学 | 924篇 |
皮肤病学 | 67篇 |
神经病学 | 310篇 |
特种医学 | 72篇 |
外科学 | 349篇 |
综合类 | 6篇 |
预防医学 | 155篇 |
眼科学 | 28篇 |
药学 | 318篇 |
中国医学 | 7篇 |
肿瘤学 | 461篇 |
出版年
2024年 | 3篇 |
2023年 | 24篇 |
2022年 | 73篇 |
2021年 | 100篇 |
2020年 | 75篇 |
2019年 | 90篇 |
2018年 | 124篇 |
2017年 | 80篇 |
2016年 | 93篇 |
2015年 | 97篇 |
2014年 | 136篇 |
2013年 | 179篇 |
2012年 | 265篇 |
2011年 | 303篇 |
2010年 | 150篇 |
2009年 | 168篇 |
2008年 | 285篇 |
2007年 | 256篇 |
2006年 | 237篇 |
2005年 | 242篇 |
2004年 | 213篇 |
2003年 | 185篇 |
2002年 | 190篇 |
2001年 | 17篇 |
2000年 | 13篇 |
1999年 | 18篇 |
1998年 | 30篇 |
1997年 | 18篇 |
1996年 | 26篇 |
1995年 | 10篇 |
1994年 | 13篇 |
1993年 | 16篇 |
1992年 | 11篇 |
1991年 | 5篇 |
1990年 | 7篇 |
1989年 | 4篇 |
1988年 | 2篇 |
1986年 | 3篇 |
1985年 | 4篇 |
1984年 | 4篇 |
1983年 | 4篇 |
1982年 | 6篇 |
1981年 | 1篇 |
1980年 | 1篇 |
1979年 | 1篇 |
1977年 | 3篇 |
排序方式: 共有3785条查询结果,搜索用时 15 毫秒
61.
62.
Joshua Burns Manoj Menezes Richard S. Finkel Tim Estilow Isabella Moroni Emanuela Pagliano Matilde Laurá Francesco Muntoni David N. Herrmann Kate Eichinger Rosemary Shy Davide Pareyson Mary M. Reilly Michael E. Shy 《Journal of the peripheral nervous system : JPNS》2013,18(2):177-180
Long‐term studies of Charcot‐Marie‐Tooth (CMT) disease across the entire lifespan require stable endpoints that measure the same underlying construct (e.g., disability). The aim of this study was to assess the relationship between the CMT Pediatric Scale (CMTPedS) and the adult CMT Neuropathy Score (CMTNSv2) in 203 children, adolescents, and young adults with CMT. There was a moderate curvilinear correlation between the CMTPedS and the CMTNSv2 (Spearman's rho ρ = 0.716, p < 0.0001), although there appears to be a floor effect of the CMTNSv2 in patients with a milder CMT phenotype. Univariate analyses indicate that the relationship between the CMTPedS and CMTNSv2 scores improves with worsening disease severity and advancing age. Although one universal scale throughout life would be ideal, our data supports the transition from the CMTPedS in childhood to the CMTNSv2 in adulthood as a continuum of measuring lifelong disability in patients with CMT. 相似文献
63.
Antonino Cannas Giuseppe Borghero Gian Luca Floris Paolo Solla Adriano Chiò Bryan J. Traynor Andrea Calvo Gabriella Restagno Elisa Majounie Emanuela Costantino Valeria Piras Loredana Lavra Carla Pani Gianni Orofino Francesca Di Stefano Paolo Tacconi Marcello Mario Mascia Antonella Muroni Maria Rita Murru Stefania Tranquilli Daniela Corongiu Marcella Rolesu Stefania Cuccu Francesco Marrosu Maria Giovanna Marrosu 《Neurogenetics》2013,14(2):161-166
Based on our previous finding of the p.A382T founder mutation in ALS patients with concomitant parkinsonism in the Sardinian population, we hypothesized that the same variant may underlie Parkinson's disease (PD) and/or other forms of degenerative parkinsonism on this Mediterranean island. We screened a cohort of 611 patients with PD (544 cases) and other forms of degenerative parkinsonism (67 cases) and 604 unrelated controls for the c.1144G > A (p.A382T) missense mutation of the TARDBP gene. The p.A382T mutation was identified in nine patients with parkinsonism. Of these, five (0.9 % of PD patients) presented a typical PD (two with familiar forms), while four patients (6.0 % of all other forms of parkinsonism) presented a peculiar clinical presentation quite different from classical atypical parkinsonism with an overlap of extrapyramidal–pyramidal–cognitive clinical signs. The mutation was found in eight Sardinian controls (1.3 %) consistent with a founder mutation in the island population. Our findings suggest that the clinical presentation of the p.A382T TARDBP gene mutation may include forms of parkinsonism in which the extrapyramidal signs are the crucial core of the disease at onset. These forms can present PSP or CBD-like clinical signs, with bulbar and/or extrabulbar pyramidal signs and cognitive impairment. No evidence of association has been found between TARDBP gene mutation and typical PD. 相似文献
64.
65.
66.
Tarkowski M Ferraris L Martone S Strambio de Castillia F Misciagna D Mazzucchelli RI Lattuada E Paraninfo G Galli M Riva A;Elvis Study Group 《AIDS research and human retroviruses》2012,28(7):693-701
Interleukin-15 (IL-15) enhances the effector mechanisms of anti-HIV immune responses and thus is considered a potential adjuvant of HIV-1 vaccine. However, there are a lack of data concerning the relationships between IL-15 expression and regulation in HIV-1-infected patients and the course of disease progression. We found that IL-15, but not IL-15Rα, is expressed at significantly higher levels in the CD14(+) monocytes [stimulated or not with interferon (IFN)-γ] of long-term nonprogressors (LTNP) than in those of HIV-1 progressors or healthy controls. There was no between-group difference in the amounts of soluble IL-15 released from the cells. We also found that like the healthy controls, the LTNP expressed the IL-15 and IL-15Rα genes in a more coordinated manner than the progressors. Our findings show that there are significant differences in IL-15 expression between patients with different courses of HIV infection, and that the coordinated expression of the IL-15 and IL-15Rα genes is dysregulated in patients with progressive disease. They also provide important information concerning the mechanisms of infection and the potential use of IL-15 as a therapeutic agent. 相似文献
67.
68.
69.
Federico Sergi Cristina Falavolti Alfredo Maria Bove Elia Luperto Emanuela Altobelli Maurizio Buscarini 《Journal of robotic surgery》2013,7(3):309-310
To present a case of laparoscopic robotic-assisted simple prostatectomy with temporary clamping of the bilateral hypogastric arteries. A 74-year-old patient with large prostatic adenoma (> 80 ml) underwent robotic-assisted laparoscopic transvesical adenoma enucleation according to Sotelo’s technique. The hypogastric arteries were isolated just below the ureteral cross with the iliac vessels and bilaterally occluded for 12 minutes during enucleation of the adenoma. The patient’s pain was mild after surgery and he required short-term analgesics and antibiotic prophylaxis. Blood loss was 80 ml. The transient occlusion of the internal iliac arteries is a proven maneuver to reduce bleeding during pelvic surgery. We propose the temporary clamping of the bilateral internal iliac arteries as a safe and rapid surgical maneuver to reduce the intraoperative risk of bleeding, especially when performing first procedures. 相似文献
70.
Roberto Michelucci Elena Pasini Sandro Malacrida Pasquale Striano Carlo Di Bonaventura Patrizia Pulitano Francesca Bisulli Gabriella Egeo Lia Santulli Vito Sofia Antonio Gambardella Maurizio Elia Arturo de Falco Angela la Neve Paola Banfi Giangennaro Coppola Patrizia Avoni Simona Binelli Clementina Boniver Tiziana Pisano Marco Marchini Emanuela Dazzo Manuela Fanciulli Yerma Bartolini Patrizia Riguzzi Lilia Volpi Fabrizio A. de Falco Anna Teresa Giallonardo Oriano Mecarelli Salvatore Striano Paolo Tinuper Carlo Nobile 《Epilepsia》2013,54(7):1288-1297