全文获取类型
收费全文 | 5682篇 |
免费 | 325篇 |
国内免费 | 52篇 |
专业分类
耳鼻咽喉 | 84篇 |
儿科学 | 186篇 |
妇产科学 | 73篇 |
基础医学 | 702篇 |
口腔科学 | 110篇 |
临床医学 | 347篇 |
内科学 | 1794篇 |
皮肤病学 | 75篇 |
神经病学 | 411篇 |
特种医学 | 164篇 |
外科学 | 740篇 |
综合类 | 33篇 |
预防医学 | 184篇 |
眼科学 | 65篇 |
药学 | 455篇 |
中国医学 | 36篇 |
肿瘤学 | 600篇 |
出版年
2022年 | 47篇 |
2021年 | 95篇 |
2020年 | 75篇 |
2019年 | 88篇 |
2018年 | 112篇 |
2017年 | 78篇 |
2016年 | 121篇 |
2015年 | 128篇 |
2014年 | 178篇 |
2013年 | 187篇 |
2012年 | 278篇 |
2011年 | 328篇 |
2010年 | 169篇 |
2009年 | 156篇 |
2008年 | 235篇 |
2007年 | 261篇 |
2006年 | 228篇 |
2005年 | 274篇 |
2004年 | 253篇 |
2003年 | 263篇 |
2002年 | 225篇 |
2001年 | 161篇 |
2000年 | 203篇 |
1999年 | 215篇 |
1998年 | 71篇 |
1997年 | 58篇 |
1996年 | 47篇 |
1995年 | 55篇 |
1994年 | 35篇 |
1993年 | 48篇 |
1992年 | 122篇 |
1991年 | 122篇 |
1990年 | 116篇 |
1989年 | 134篇 |
1988年 | 112篇 |
1987年 | 89篇 |
1986年 | 86篇 |
1985年 | 101篇 |
1984年 | 60篇 |
1983年 | 41篇 |
1982年 | 21篇 |
1979年 | 47篇 |
1975年 | 25篇 |
1974年 | 21篇 |
1973年 | 25篇 |
1972年 | 25篇 |
1970年 | 27篇 |
1969年 | 26篇 |
1968年 | 25篇 |
1967年 | 20篇 |
排序方式: 共有6059条查询结果,搜索用时 15 毫秒
21.
Monitoring the protective effects of minocycline treatment with radiolabeled annexin V in an experimental model of focal cerebral ischemia. 总被引:3,自引:0,他引:3
Xian Nan Tang Qing Wang Maya A Koike Danye Cheng Michael L Goris Francis G Blankenberg Midori A Yenari 《Journal of nuclear medicine》2007,48(11):1822-1828
Minocycline is an antibiotic now recognized to have antiapoptotic and antiinflammatory properties. Because of these properties, minocycline may be of benefit in reducing neuronal apoptosis from ischemia and subsequent postischemic inflammation if administered soon after a stroke. We now explore the feasibility of using (99m)Tc-annexin V, an in vivo marker of apoptosis, with SPECT to monitor the antiapoptotic effects of minocycline therapy. METHODS: CB6/F1 adult male mice underwent unilateral distal middle cerebral artery occlusion (dMCA) occlusion and were imaged and sacrificed at 1, 3, 7, or 30 d after injury. Animals were given minocycline (or vehicle) 30 min and 12 h after dMCA occlusion and then given 22.5 mg/kg twice daily for up to 7 d. Before imaging, behavioral tests were performed to evaluate the neurologic function. After imaging, brains were collected for histology and assessed for the degree of apoptosis and microglial activation. RESULTS: (99m)Tc-Annexin V uptake in injured hemispheres was significantly decreased 2- to 3-fold by minocycline at all time points. Minocyline reduced infarct size as seen histologically and improved behavioral indices as late as 30 d. Infarct volume as seen histologically correlated with radiolabeled annexin V uptake seen by SPECT. In situ fluorescent microscopy demonstrated that annexin V bound primarily to neurons at 1 and 3 d, with a shift toward microglia by 7 and 30 d. CONCLUSION: We found that minocycline significantly reduces neuronal apoptosis and infarct size and improves neurologic outcome in mice after acute focal cortical ischemia. 相似文献
22.
23.
Takehiko Shimoyama Katsuo Yoshiya Yasushi Yamato Teruaki Koike Keiichi Honma 《General thoracic and cardiovascular surgery》2009,57(6):310-314
Malignant peripheral nerve sheath tumors (MPNSTs; malignant schwannomas) rarely occur in the anterior mediastinum, and their
prognosis is poor. A 75-year-old man was referred to our hospital for examination of an anterior mediastinal tumor. A computed
tomography-guided percutaneous needle biopsy revealed only fibrosis. The tumor was completely excised via a median sternotomy
with partial resection of the pericardium and right upper lobe of the lung. Thereafter, the tumor was diagnosed as a storiform-pleomorphic
type of malignant fibrous histiocytoma. At 1 year after the surgery, a distant metastasis was found in the interlobular space
between the right middle and lower lobes. The tumor was completely excised via a right posterolateral thoracotomy. Reexamination
of the primary and secondary tumors revealed an MPNST. No recurrence was found up to 5 years after the second surgery without
adjuvant chemotherapy or radiation therapy. However, he died from multiple lung metastases after 6 years. 相似文献
24.
Kiyoaki Takaba Masaki Aota Hiroyuki Koike Yutaka Konishi 《The Japanese Journal of Thoracic and Cardiovascular Surgery》2004,52(4):194-197
Aneurysm of the innominate artery is uncommon compared with other peripheral aneurysms, and holds the potential for rupture,
embolization, or thrombosis as well as various complications caused by compression to the adjacent structures. The most effective
treatment for this condition is surgical resection, but the earlier reports described high mortality rates. We report the
case of an 83-year-old asymptomatic woman with an aneurysm in the innominate artery, which was successfully resected and repaired
with the use of modern surgical techniques of hypothermic circulatory arrest and selective cerebral perfusion. Aggressive
surgical intervention should be employed despite the fact that a patients is asymptomatic. 相似文献
25.
26.
W Higuchi Y Moriyama K Kishi T Koike A Shibata S Shinada I Tada A Miura 《Bone marrow transplantation》1991,7(2):163-166
We describe a patient with acute lymphoblastic leukemia (ALL) in whom hemopoiesis recovered after an autologous marrow graft purged by in vitro hyperthermia. A 17-year-old woman was diagnosed as having ALL in April 1985. After clinical remission was induced, marrow cells were harvested. The marrow cells were treated with hyperthermia at 42.0 degrees C for 1 h in the presence of alpha-interferon to eliminate residual leukemic cells, and then cryopreserved. In January 1990, during her fourth remission she was treated with busulfan and cyclophosphamide, and then received the thawed autologous marrow. Her hematopoietic recovery was prompt with normal trilineage regeneration without any life-threatening complications. She is in good health without evidence of a leukemic relapse at 6 months after autologous bone marrow transplantation. This case suggests that human multilineage progenitor cells retain self-renewal capacity in vivo even after treatment with heat and alpha-interferon in vitro followed by the freezing and thawing procedures. 相似文献
27.
K Hagino H Oshige K Ozawa K Kudo M Koide R Sugita K Adachi H Koike 《Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan》1991,111(6):293-298
The effect of XKJ-001, a crude drug preparation based on Seisho-ekki-to, was investigated on the hematocrit, plasma volume, extracellular and interstitial fluid volumes as well as water excretion in mice. Mice were housed in an animal room maintained at 34 degrees C for 3 d with water and food freely available. While the hematocrit, extracellular and interstitial fluid volumes increased, the plasma volume decreased. These results suggest that the distribution of body water in mice housed at high environmental temperature exhibit the state of water metabolism disorders (Suitai) described in Kampo medicine. After the administration of XKJ-001 (3 g/kg, once a day) for 5 d, mice were housed in an animal room maintained at 34 degrees C for 3 d. The administration of XKJ-001 was allowed to continue on the day 0, day 1 and day 2. XKJ-001 inhibited the increase in hematocrit and the changes in body water distribution of mice induced by high environmental temperature. An effect of XKJ-001 on water excretion in mice was investigated in comparison with hydrochlorothiazide (HTZ). Distilled water (D.W., 100 ml/kg) or bicarbonate saline (B.S., 100 ml/kg) was intraperitoneally injected immediately after the oral administration of XKJ-001 (1.5 g/kg) or HTZ (15 mg/kg). The water excretion was enhanced after 3 h for XKJ-001 and after 6 h for HTZ after the intraperitoneal injection of D.W. As for the intraperitoneal injection of BS, HTZ enhanced the water excretion, however, XKJ-001 exhibited no effect. These results suggest that XKJ-001 has activities on water maldistribution and facilitates the water excretion. 相似文献
28.
T. Nakada K. Umeda H. Koike T. Akiya T. Katayama 《International urology and nephrology》1987,19(4):377-384
Twelve patients with ureteral tumours with or without ipsilateral renal pelvic neoplasms were retrospectively analysed. Haematuria
was the most common symptom. Location of all tumours was preoperatively detected by conventional diagnostic methods, such
as intravenous or retrograde pyelography, washing cytology of the upper urinary tract, computed tomography, echogram and abdominal
aortography. Cumulative proportion survivals of 1, 3 and 5 years were 81.9%, 68.2% and 45.5%, respectively. Patients with
high Karnovsky rating survived longer (p<0.05) than those with low rating. Patients with low-stage tumours (T1, T2) showed longer survival rate (p<0.001) than those with high-stage tumours (T3, T4). Vascular invasion of tumour cells was present in removed specimens in 4 out of 7 patients who died or are alive with cancer,
but none in those who survived without disease. Good therapeutic response could not be achieved unless surgery was performed. 相似文献
29.
Mitsutoshi Satoh Keisuke Enomoto Katsuo Koike 《The Journal of pharmacy and pharmacology》2001,53(1):103-108
The antagonistic effects of MDL73005EF and tamsulosin and partial agonists clonidine and tizanidine at rat thoracic aorta and rabbit iliac artery alpha1-adrenoceptors were investigated in this study. Selective alpha1-adrenoceptor antagonists MDL73005EF and tamsulosin dose-dependently shifted the concentration-response curves for noradrenaline to the right. Schild plots of the results obtained from the inhibition by MDL73005EF (pA2 8.30 +/- 0.04) and tamsulosin (pA2 10.51 +/- 0.06) of noradrenaline yielded a straight line with a slope of unity in rat thoracic aorta. The slopes of Schild plots obtained from the inhibition by MDL73005EF and tamsulosin of noradrenaline were significantly different from unity in rabbit iliac artery. Schild plots of the results obtained from the inhibition by clonidine and tizanidine of noradrenaline yielded a straight line with a slope of unity in rat thoracic aorta (pA2 7.08 +/- 0.04 and 7.32 +/- 0.04, respectively). These results suggest that alpha1D-adrenoceptors play a significant role in the alpha1-adrenoceptor-agonist-induced contraction of rat thoracic aorta and rabbit iliac artery, and that clonidine and tizanidine interact with the alpha1D-adrenoceptor subtype as competitive antagonists in rat thoracic aorta. 相似文献
30.
Y Akatsuka H Maeda S Tsuzuki T Sugihara S Minami Y Kodera K Koike 《[Rinshō ketsueki] The Japanese journal of clinical hematology》1992,33(3):322-327
The authors report an 18-year-old female who developed severe hemolytic reaction and delayed neutrophil recovery after bone marrow transplantation (BMT) for aplastic anemia from her HLA-identical sibling. She had received much transfusion (61 units of red blood cells including 4 units of fresh whole blood from her parents and 350 units of platelets) for 12 years before BMT. To prevent graft rejection, she received an intensified preparative regimen consisted of cyclophosphamide 200 mg/kg followed by 5 Gy total body irradiation and 5 Gy total lymphoid irradiation. Prophylaxis for GVHD was short term methotrexate and cyclosporin-A. Despite of the removal of the red cells from the marrow, marked hemolytic reaction caused by antibodies directed to rh" (E) and hr' (c) red cell antigens was observed when rh" (E) and hr' (c) positive donor erythroid began to recover. The recovery of neutrophils, especially the fraction of segmented cells was also delayed. Flow cytometry showed that the serially collected patient's sera reacted to neutrophils derived from both patient's blood on the 64th post-transplant day and the donor's blood. The reactivity was strongest in pre-BMT sera. We conclude that residual antibodies sensitized before BMT are a major cause of these hematological problems. 相似文献