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排序方式: 共有344条查询结果,搜索用时 375 毫秒
31.
32.
Takashi Ohta Minoru Hosaka Hiroyuki Ishibashi Ikuo Sugimoto Eijiro Mihara Kenji Hida Noriyuki Takeuchi Jin Hachiya Masahiko Kato Hideki Kazui Yoshihisa Nagata 《Surgery today》1998,28(2):156-161
(Received for publication on Nov. 5, 1996; accepted on May 12, 1997) 相似文献
33.
Shozo Miyake Shigeru Yasuraoka Yasuyoshi Kiryu Eijiro Satoyoshi Takeshi Kurata Yuzo Aoyama 《Acta neuropathologica》1977,40(1):91-93
Summary An adult case of herpes simplex encephalitis was studied after autopsy. Postmortem examination revealed necrotizing encephalitis associated with Cowdry type A intranuclear inclusion bodies in glial cells. Herper simplex virus type 1 was isolated from the removed brain. Herpes simplex virus antigens were detected diffusely in wide areas of the brain by immunofluorescent test and viral particles characteristic to herpes simplex virus were demonstrated by electron microscopy. There was an apparent discrepancy between severity of histological changes and distribution of virus antigen. 相似文献
34.
Eijiro Satoyoshi 《Brain & development》1983,5(3):350
35.
Akahane M Akahane T Matheny SL Shah A Okajima E Thorgeirsson UP 《International journal of cancer. Journal international du cancer》2006,118(4):841-849
Vascular endothelial growth factor-D (VEGF-D) stimulates growth of vascular and lymphatic endothelial cells by signaling through the tyrosine kinase receptors KDR (VEGFR-2) and Flt-4 (VEGFR-3). In the present study, we examined the effects of VEGF-D on apoptosis in human MCF-7 and MDA-MB-231 breast carcinoma cells. Because VEGF-D was not expressed constitutively in vitro, stable VEGF-D transfectants were produced. The VEGF-D-expressing MCF-7 and MDA-MB-231 lines displayed resistance to apoptosis induced by hypoxia, staurosporin and cycloheximide. Increased Bcl-2 expression, decreased homogenous caspase activities and inhibition of poly(ADP-ribose) polymerase cleavage were associated with inhibition of apoptosis in VEGF-D-expressing clones. Also, caspase-3 activation was suppressed in the VEGF-D expressing MDA-MB-231 clone. The antiapoptotic effect of VEGF-D in vitro was recapitulated in vivo using VEGF-D-expressing MDA-MB-231 xenografts. The lack of VEGFR-2 protein expression by Western blot and ineffectiveness of a neutralizing VEGFR-2 antibody in eliminating the antiapoptotic effects of VEGF-D suggest a different and yet unknown signaling mechanism. Our findings indicate that VEGF-D has a novel function as a survival factor of breast carcinoma cells in addition to its established functions as an angiogenic and lymphangiogenic factor. 相似文献
36.
Sawazaki H Segawa T Yoshida K Kawahara T Inoue T Soda T Kanba T Yoshimura K Takahashi T Nakamura E Nishiyama H Ito N Kamoto T Ogawa O 《Hinyokika kiyo. Acta urologica Japonica》2006,52(11):875-878
A 72-year-old female presented with the complaint of left lower abdominal swelling in May, 2005. Laboratory analysis revealed elevated white blood cell counts and C-reactive protein. Abdominal computed tomography showed left ureteral calculi, left hydronephrosis and a mass extending through the perinephric space, psoas major muscle into the left flank and lower abdomen. Echo-guided needle mass biopsy was performed. Histopathological findings revealed xanthogranulomatous changes. Under the diagnosis of diffuse xanthogranulomatous pyelonephritis extended into psoas muscle and subcutaneous tissue, antibiotic therapy was given for 5 months. After reduction of subcutaneous mass, left nephroureterectomy was performed. Histopathological findings revealed xanthogranulomatous pyelonephritis and ureteritis. Postoperative course was uneventful without any relapse of inflammation. 相似文献
37.
Eijiro Tagashira Tameo Hiramori Tomoko Urano Kenzo Nakao Saizo Yanaura Yukio Kuroiwa 《Psychopharmacology》1982,77(2):101-104
This research was designed to determine whether the convulsion-eliciting action of tranylcypromine (TCP) during barbital (B) withdrawal was specific to physical dependence on B, and to compare the findings with the action of pentetrazol (PTZ). Challenge with 15–20 mg/kg IP TCP at 48 h of B withdrawal resulted in the elicitation of clonictonic convulsion (CTC) in all rats (N=6) within 10 min. Another challenge with 5–20 mg/kg TCP led to the doserelated precipitation and intensification of CTC. The CTC-inducing action of TCP was relatively reduced as the B withdrawal signs were gradually mitigated. In other words, when challenge with the drug was made at 72h of B withdrawal, the time of CTC onset was prolonged, and the incidence was reduced to 50% in parallel with abolition of the other withdrawal signs. A challenge at 120 h of B withdrawal when the vital signs had almost recovered to prewithdrawal level failed to induce even the prodromal signs of convulsion. In all rats exhibiting only mild to moderate withdrawal signs (such as hyperirritability, hyper-reflexia, anorexia, weight loss), 40 mg/kg TCP was required to induce CTC during B withdrawal, which was twice the dose required in severely dependent rats. Other monoamine oxidase inhibitors, i.e., pargyline, iproniazid, and clorgyline, elicited no CTC during B withdrawal. Methamphetamine was without effect on B withdrawal convulsions. From these findings, the convulsive threshold for TCP during B withdrawal proved well correlated to the grade of B-dependence and the duration of B-withdrawal signs. 相似文献
38.
Eijiro Okada Morio Matsumoto Hirokazu Fujiwara Yoshiaki Toyama 《European spine journal》2011,20(4):585-591
An association between progression of cervical disc degeneration and that of lumbar disc degeneration has been considered
to exist. To date, however, this association has not yet been adequately studied. Age-related changes in the cervical intervertebral
discs were evaluated by magnetic resonance imaging (MRI) in patients with lumbar disc herniation, and compared with the MRI
findings of healthy volunteers without lower back pain. The purpose of this study was to clarify whether the prevalence of
asymptomatic cervical disc degeneration is higher in patients with lumbar disc herniation than in healthy volunteers. The
study was conducted on 51 patients who were diagnosed as having lumbar disc herniation and underwent cervical spine MRI. The
patients consisted of 34 males and 17 females ranging in age from 21–83 years (mean 46.9 ± 14.5 years) at the time of the
study. The control group was composed of 113 healthy volunteers (70 males and 43 females) aged 24–77 years (mean 48.9 ± 14.7 years),
without neck pain or low back pain. The percentage of subjects with degenerative changes in the cervical discs was 98.0% in
the lumbar disc herniation group and 88.5% in the control group (p = 0.034). The presence of lumbar disc herniation was associated significantly with decrease in signal intensity of intervertebral
disc and posterior disc protrusion in the cervical spine. None of the MRI findings was significantly associated with the gender,
smoking, sports activities, or BMI. As compared to healthy volunteers, patients with lumbar disc herniation showed a higher
prevalence of decrease in signal intensity of intervertebral disc and posterior disc protrusion on MRI of the cervical spine.
The result of this study suggests that disc degeneration appears to be a systemic phenomenon. 相似文献
39.
40.
Kazuhide Higuchi Eiji Umegaki Toshio Watanabe Yukiko Yoda Eijiro Morita Mitsuyuki Murano Satoshi Tokioka Tetsuo Arakawa 《Journal of gastroenterology》2009,44(9):879-888
Non-steroidal anti-inflammatory drugs (NSAIDs) are well known to cause gastroduodenal mucosal lesions as an adverse effect.
Recently, the serious problem of NSAID-induced small intestinal damage has become a topic of great interest to gastroenterologists,
since capsule endoscopy and balloon enteroscopy are available for the detection of small intestinal lesions. Such lesions
have been of great concern in clinical settings, and their treatment and prevention must be devised as soon as possible. The
prevalence of NSAIDs-induced small intestinal injury is higher than had been expected. Recent studies show that more than
50% of patients taking NSAIDs have some mucosal damage in the small intestine. The gross appearance of NSAID-induced enteropathy
varies, appearing variously as diaphragm-like strictures, ulcers, erosions, and mucosal redness. To investigate NSAID-induced
enteropathy, and to rule out other specific enteropathies, other useful methods (in addition to capsule endoscopy and balloon
enteroscopy) include such modalities as radiological examination of the small intestine, the permeability test, scintigraphy
or the fecal excretion test using 111Indium-labeled white blood cells, and measurement of the fecal calprotectin concentration. Diaphragm-like strictures and bleeding
from mucosal breaks may be treatable with interventional enteroscopy. Misoprostol, metronidazole, and sulfasalazine are frequently
used to treat NSAID-induced enteropathy, but have undesirable effects in some cases. In the experimental model, we confirmed
that several existing drugs for gastroduodenal ulcers prevented indomethacin-induced small intestinal injury. Such drugs may
be useful for preventing the adverse effects of NSAIDs not only in the stomach but also in the small intestine. We hope to
examine these drugs in future clinical studies. 相似文献