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排序方式: 共有754条查询结果,搜索用时 0 毫秒
91.
Dr. Hans Reinhard Eichelbaum 《Archives of dermatological research》1922,139(2):235-259
Ohne Zusammenfassung 相似文献
92.
93.
G. Mikus C. Zekorn T. Brecht M. Eichelbaum 《European journal of clinical pharmacology》1991,41(2):99-103
Summary The haemodynamic effects of an i.v. infusion of 2 mg nitrendipine have been studied in six healthy volunteers.Nitrendipine significantly decreased the systolic (–8.3%) diastolic (–19.9%) and mean arterial (–11.6%) blood pressures and the peripheral vascular resistance (–57.8%), and significantly increased leg blood flow (+128%).Stroke volume did not change. Due to the increase in heart rate (+28.5%), the cardiac output (2.8.2%) rose significantly. The haemodynamic effects were closely related to the serum nitrendipine concentration. The sigmoidal Emax-model was appropriate to describe the data.Pronounced interindividual differences in the serum nitrendipine concentrations required to elicit 50% of the maximum haemodynamic effect (EC50) were observed. The EC50 for the increase in leg blood flow ranged from 2.9 to 30.9 ng/ml and for the reduction in peripheral vascular resistance from 2.1 to 25.7 ng/ml. Interindividual differences in EC50 values were less pronounced if based on unbound serum nitrendipine levels.The fraction of nitrendipine not bound to serum proteins showed a three-fold difference between subjects, with free fractions ranging from 0.011 to 0.036. The unbound EC50 values for the increase in leg blood flow varied between 0.06 and 0.44 ng/ml and for the reduction in peripheral vascular resistance from 0.07 to 0.35 ng/ml.Based on the serum concentrations associated with comparable haemodynamic effects nitrendipine was at least three-times more potent than nifedipine. 相似文献
94.
Mafee MF; Peyman GA; Grisolano JE; Fletcher ME; Spigos DG; Wehrli FW; Rasouli F; Capek V 《Radiology》1986,160(3):773-780
Twenty-one patients with intraocular disease were studied by magnetic resonance (MR) imaging and computed tomography (CT). In 13 cases, malignant uveal melanoma was considered the likely diagnosis. Both imaging methods were accurate in determining the location and size of uveal melanomas. MR imaging was superior for the assessment of possible associated retinal detachment, for assessment of vitreous change, and for differentiating uveal melanoma from choroidal hemangioma and choroidal detachment. A case of retinal gliosis could not be differentiated from uveal melanoma by either technique. Uveal melanomas appeared as hyperintense lesions on T1-weighted images and as hypointense lesions on T2-weighted images. High signal intensity of the vitreous was observed in patients with vitritis and in those who were thought to have protein leaking into the vitreous as a result of impairment of the retinal-blood barrier. 相似文献
95.
WM WONG SK LAM TSM TONG KL CHEUNG VSY TANG HHX XIA KC LAI WHC HU CK CHAN MF YUEN AOO CHAN BCY WONG 《Journal of digestive diseases》2003,4(3):132-135
OBJECTIVE: To evaluate the accuracy of a rapid assay that wasdeveloped to detect Helicobacter pylori antigen in the stool,using the principle of immunochromatography, in the Chinese population. METHODS: Eligible patients without prior treatment of H.pylori were recruited. An in‐house rapid urease test (RUT) andhistology were used as the gold standard. The results of the rapidstool antigen test were compared with the gold standard. RESULTS: Valid rapid stool antigen test results for interpretationwere obtained from 94 consecutive patients (mean age: 52.5, range:22?82 years). Sensitivity, specificity, positive predictivevalue, negative predictive value and accuracy were, respectively, 77.5%,87.0%, 81.6%, 83.9% and 83.0%.The test was easy to perform and results were available within 15 min. CONCLUSION: The rapid stool antigen test using immunochromatography accuratelydiagnoses H. pylori infection in Chinese patients. 相似文献
96.
97.
98.
Invasive thymoma: treatment with postoperative radiation therapy 总被引:5,自引:0,他引:5
Latz D; Schraube P; Oppitz U; Kugler C; Manegold C; Flentje M; Wannenmacher MF 《Radiology》1997,204(3):859
99.
Identification of the gene encoding the human mitochondrial RNA polymerase (h-mtRPOL) by cyberscreening of the Expressed Sequence Tags database 总被引:12,自引:3,他引:9
Tiranti V; Savoia A; Forti F; D'Apolito MF; Centra M; Rocchi M; Zeviani M 《Human molecular genetics》1997,6(4):615-625
A gene cloning strategy based on the screening of the Expressed Sequence
Tags database (dbEST) using sequences of mitochondrial housekeeping
proteins of yeast was employed to identify the cDNA encoding the precursor
of the human mitochondrial RNA polymerase (h- mtRPOL). The 3831 bp h-mtRPOL
cDNA is located on chromosome 19p13.3 and encodes a protein of 1230 amino
acid residues. The protein sequence shows significant homologies with
sequences corresponding to mitochondrial RNA polymerases from lower
eukaryotes, and to RNA polymerases from several bacteriophages. The
mitochondrial RNA polymerase carries out the central activity of
mitochondrial gene expression and, by providing the RNA primers for
replication- initiation, is also implicated in the maintenance and
propagation of the mitochondrial genome. Genes involved in the control of
mtDNA replication and gene expression are attractive candidates for human
disorders due to abnormalities of nucleo-mitochondrial intergenomic
signalling. The availability of the h-mtRPOL cDNA will allow us to test its
role in mitochondrial pathology. In addition, we propose the
'cyberscreening' of dbEST, based on yeast/human cross-species comparison,
as a powerful, simple, rapid and inexpensive method, that may accelerate
several-fold the molecular dissection of the human mitochondrial proteome.
相似文献
100.
M-LA Schuttelaar MF Jonkman 《Journal of the European Academy of Dermatology and Venereology》2003,17(1):91-93
We report a patient with Churg-Strauss syndrome (CSS) with asthma, eosinophilia, nasal polyposis and ANCA-associated multisystem vasculitis, who's skin eruption started with erythematous urticarial-plaques followed by haemorrhagic bullae. Histology of the plaques revealed 'flame figures' in the dermis with no granulomatous or vasculitic process, consistent with the diagnosis of eosinophilic cellulitis or Wells' syndrome. The association of CSS and Wells' syndrome observed in this patient may have a common pathogenesis. CSS may induce Wells' syndrome by an unknown factor. 相似文献