全文获取类型
收费全文 | 173699篇 |
免费 | 12240篇 |
国内免费 | 4441篇 |
专业分类
耳鼻咽喉 | 2349篇 |
儿科学 | 2498篇 |
妇产科学 | 2266篇 |
基础医学 | 25417篇 |
口腔科学 | 3850篇 |
临床医学 | 17852篇 |
内科学 | 29481篇 |
皮肤病学 | 4403篇 |
神经病学 | 12738篇 |
特种医学 | 9239篇 |
外国民族医学 | 19篇 |
外科学 | 21605篇 |
综合类 | 9384篇 |
现状与发展 | 17篇 |
一般理论 | 31篇 |
预防医学 | 9884篇 |
眼科学 | 4311篇 |
药学 | 16513篇 |
51篇 | |
中国医学 | 4211篇 |
肿瘤学 | 14261篇 |
出版年
2024年 | 187篇 |
2023年 | 1281篇 |
2022年 | 3606篇 |
2021年 | 6759篇 |
2020年 | 3950篇 |
2019年 | 4492篇 |
2018年 | 5312篇 |
2017年 | 4505篇 |
2016年 | 5382篇 |
2015年 | 7649篇 |
2014年 | 9114篇 |
2013年 | 10089篇 |
2012年 | 14986篇 |
2011年 | 14839篇 |
2010年 | 9121篇 |
2009年 | 7567篇 |
2008年 | 10299篇 |
2007年 | 9938篇 |
2006年 | 8997篇 |
2005年 | 8480篇 |
2004年 | 7010篇 |
2003年 | 6456篇 |
2002年 | 5515篇 |
2001年 | 4310篇 |
2000年 | 3773篇 |
1999年 | 3075篇 |
1998年 | 1461篇 |
1997年 | 1210篇 |
1996年 | 868篇 |
1995年 | 875篇 |
1994年 | 690篇 |
1993年 | 515篇 |
1992年 | 1014篇 |
1991年 | 890篇 |
1990年 | 804篇 |
1989年 | 725篇 |
1988年 | 579篇 |
1987年 | 584篇 |
1986年 | 449篇 |
1985年 | 429篇 |
1984年 | 300篇 |
1983年 | 212篇 |
1982年 | 157篇 |
1981年 | 184篇 |
1980年 | 143篇 |
1979年 | 236篇 |
1978年 | 166篇 |
1976年 | 138篇 |
1974年 | 147篇 |
1973年 | 132篇 |
排序方式: 共有10000条查询结果,搜索用时 31 毫秒
21.
Can EGFR mutation status be reliably determined in pre‐operative needle biopsies from adenocarcinomas of the lung?
下载免费PDF全文
![点击此处可从《APMIS : acta pathologica, microbiologica, et immunologica Scandinavica》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Kim Hein Lindahl Flemming Brandt Sørensen Søren Peter Jonstrup Karen Ege Olsen Siegfried Loeschke 《APMIS : acta pathologica, microbiologica, et immunologica Scandinavica》2015,123(4):289-297
The identification of EGFR mutations in non‐small‐cell lung cancer is important for selecting patients, who may benefit from treatment with EGFR tyrosine kinase inhibitors. The analysis is usually performed on cytological aspirates and/or histological needle biopsies, representing a small fraction of the tumour volume. The aim of the present investigation was to evaluate the diagnostic performance of this molecular test. We retrospectively included 201 patients with primary adenocarcinoma of the lung. EGFR mutation status (exon 19 deletions and exon 21 L858R point mutation) was evaluated on both pre‐operative biopsies (131 histological and 70 cytological) and on the surgical specimens, using PCR. Samples with low tumour cell fraction were assigned to laser micro‐dissection (LMD). We found nine (4.5%) patients with EGFR mutation in the lung tumour resections, but failed to identify mutation in one of the corresponding pre‐operative, cytological specimens. Several (18.4%) analyses of the pre‐operative biopsies were inconclusive, especially in case of biopsies undergoing LMD and regarding exon 21 analysis. Discrepancy of mutation status in one patient may reflect intra‐tumoural heterogeneity or technical issues. Moreover, several inconclusive results in the diagnostic biopsies reveal that attention must be paid on the suitability of pre‐operative biopsies for EGFR mutation analysis. 相似文献
22.
Michelle E. Wilson Charles Kim Jacqueline Carrasco 《Orbit (Amsterdam, Netherlands)》2016,35(5):288-291
A 48-year-old smoker with a history of hyperthyroidism treated 10 years prior to presentation with radioactive iodine ablation of the thyroid gland presented to his ophthalmologist with a 2-week history of transient loss of vision in the right eye occurring for 1 to 2 hours each morning. He denied ocular pain, diplopia or change in the prominence of one or both eyes. Examination revealed 2 mm of relative proptosis on the right, bilateral temporal flare and lower lid retraction. There was minimal upper lid retraction and no evidence of lid lag. Ocular motility was full. Dilated fundoscopic examination revealed bilateral optic nerve edema, right more than left. CT of the orbit demonstrated enlargement of the extraocular muscles bilaterally with marked enlargement of the right medial rectus and left inferior rectus muscles resulting in crowding at the orbital apex bilaterally. Laboratory testing revealed the patient to be hyperthyroid. The patient was treated with high dose oral steroids followed by orbital radiation. Hyperthyroidism was managed by the patient’s primary care physician. Visual symptoms rapidly improved with oral steroids and orbital radiation. Optic nerve edema completely resolved. Repeat CT imaging demonstrated a reduction in the enlargement of the extraocular muscles with relief of bilateral optic nerve compression. 相似文献
23.
Sundaram Kavin Piuzzi Nicolas S. Patterson Brendan M. Stearns Kim L. Krebs Viktor E. Mont Michael A. 《European journal of orthopaedic surgery & traumatology : orthopedie traumatologie》2020,30(3):447-453
European Journal of Orthopaedic Surgery & Traumatology - The goals of this study were to compare patient satisfaction and wound-related complications in patients receiving 2-octyl cyanoacrylate... 相似文献
24.
25.
Hyo-Kon Kim Sung-Han Ha Gi-Jun Lee Sun-O Yu Jung-Rae Kim 《Clinics in Orthopedic Surgery》2015,7(3):414-417
Synovial chondromatosis is a rare lesion in the wrist, but some cases in the distal radioulnar joint have been reported and previous case reports emphasize joint calcifications, shown on preoperative plain radiographs. We report an extremely uncommon case of synovial chondromatosis in the pisotriquetral joint, in which radiographs and magnetic resonance imaging did not demonstrate apparent calcified bodies. In our case, for the accurate diagnosis and treatment, surgical exploration of the joint and synovectomy with removal of loose bodies was performed. 相似文献
26.
27.
28.
In the 6th Basic Plan for Long-Term Electricity Supply and Demand (6th BPE) for Korea, for the first time, the environmental costs of air pollution caused by oxides of sulfur (SOx), oxides of nitrogen (NOx), and particulate matters (PM) from power plants were estimated and included. However, several deficiencies in evaluating the environmental costs were found. In this study, (1) the validity of the environmental costs used in the 6th BPE was assessed, (2) a systematic approach was suggested and used to improve the environmental costs estimation, and (3) the sensitivity of the cost of generating electricity to the environmental costs by fuel type with the proposed approach was discussed. We found that the applied environmental costs used in the 6th BPE did not fully include the demographic characteristics of Korea. By applying more realistic parameter values, it was found that the newly estimated environmental cost was about 23 times higher than the cost estimated in the original 6th BPE for coal-fired power plants and about 1.5 times higher for liquefied natural gas (LNG)-fired power plants, suggesting that LNG-fired power plants are more economical if using more realistic environmental costs. Thus, it is critical to check the validity of parameter values when calculating environmental costs. 相似文献
29.
目的 分析社区"5+1"糖尿病分阶段达标管理对2型糖尿病患者生存质量的干预效果及其影响因素,为提高患者生存质量提供依据。方法 采用分层整群抽样的方法在山西省、江苏省和宁夏回族自治区选择12个社区卫生服务中心,分别作为干预组(管理方式:社区"5+1"糖尿病分阶段达标管理)、对照组[管理方式:依据《国家基本公共卫生服务规范(2011年版)》的相关要求],进行为期2年的随访观察。采用面对面问卷调查的方式,收集患者的人口学信息等基本信息;采用健康调查简表(SF-36)对患者在干预前后测量生存质量。采用SAS 9.4软件进行双重差分法以及多重线性回归模型分析。结果 基线时共纳入2 467名研究对象,终末时共1 924人接受了为期2年完整的随访管理。干预后,干预组、对照组患者生理健康维度(PCS)、心理健康维度(MCS)评分变化净差值分别为13.6分、29.8分。多重线性回归分析结果显示,影响患者PCS得分的主要因素有年龄、医保类型、基线PCS得分以及所在地区,影响患者MCS得分的主要因素有年龄、医保类型、基线MCS得分、是否合并高血压以及所在地区。结论 社区"5+1"糖尿病分阶段达标管理对2型糖尿病患者生存质量的干预效果较好。 相似文献
30.
Changhyun Kim B.S. Brittany G. Craiglow M.D. Kalman L. Watsky M.D. Richard J. Antaya M.D. 《Pediatric dermatology》2015,32(4):e161-e162
A 17‐year‐old boy presented with recurring severe dermatitis of the face of 5‐months duration that resembled impetigo. He had been treated with several courses of antibiotics without improvement. Biopsy showed changes consistent with allergic contact dermatitis and patch testing later revealed sensitization to benzoyl peroxide, which the patient had been using for the treatment of acne vulgaris. 相似文献