全文获取类型
收费全文 | 11652篇 |
免费 | 699篇 |
国内免费 | 69篇 |
专业分类
耳鼻咽喉 | 65篇 |
儿科学 | 360篇 |
妇产科学 | 249篇 |
基础医学 | 1988篇 |
口腔科学 | 111篇 |
临床医学 | 1115篇 |
内科学 | 2877篇 |
皮肤病学 | 191篇 |
神经病学 | 1034篇 |
特种医学 | 295篇 |
外科学 | 1584篇 |
综合类 | 35篇 |
现状与发展 | 1篇 |
一般理论 | 9篇 |
预防医学 | 710篇 |
眼科学 | 78篇 |
药学 | 744篇 |
中国医学 | 21篇 |
肿瘤学 | 953篇 |
出版年
2023年 | 44篇 |
2022年 | 73篇 |
2021年 | 241篇 |
2020年 | 149篇 |
2019年 | 238篇 |
2018年 | 278篇 |
2017年 | 183篇 |
2016年 | 219篇 |
2015年 | 239篇 |
2014年 | 377篇 |
2013年 | 508篇 |
2012年 | 845篇 |
2011年 | 898篇 |
2010年 | 492篇 |
2009年 | 499篇 |
2008年 | 807篇 |
2007年 | 864篇 |
2006年 | 852篇 |
2005年 | 913篇 |
2004年 | 868篇 |
2003年 | 809篇 |
2002年 | 770篇 |
2001年 | 88篇 |
2000年 | 40篇 |
1999年 | 112篇 |
1998年 | 168篇 |
1997年 | 124篇 |
1996年 | 89篇 |
1995年 | 94篇 |
1994年 | 74篇 |
1993年 | 77篇 |
1992年 | 43篇 |
1991年 | 41篇 |
1990年 | 36篇 |
1989年 | 28篇 |
1988年 | 27篇 |
1987年 | 33篇 |
1986年 | 27篇 |
1985年 | 8篇 |
1984年 | 16篇 |
1983年 | 19篇 |
1982年 | 15篇 |
1981年 | 22篇 |
1980年 | 27篇 |
1979年 | 9篇 |
1978年 | 7篇 |
1977年 | 8篇 |
1976年 | 5篇 |
1975年 | 3篇 |
1968年 | 3篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
151.
Dominique S Blanc 《Infection, genetics and evolution》2004,4(3):193-197
While molecular typing methods are widely used to help the epidemiologist in the investigation of outbreaks, their use for the investigation of endemic infections has been limited. For the investigation of a micro-epidemiological setting such as the understanding of endemic nosocomial infections, discriminant methods are needed, such as pulsed field gel electrophoresis (PFGE), or PCR related typing methods. However, for long-term surveillance, preference should be given to typing methods that give definite results. The identification of the source or reservoir is only possible with comprehensive screening of the environment and the endogenous flora of patients and staff, and therefore, requires significant resources. However, cross-contamination or the existence of a common exogenous source might be investigated by typing clinical isolates during non-epidemic periods. Cross-contamination is suspected when isolates from different patients belong to the same type and when an epidemiological relation can be established. Thus, molecular typing makes it possible to track the dissemination of specific clones, it may facilitate the breaking down of endemic transmission to the level of micro-epidemics. This is illustrated by the example of one investigation of Pseudomonas aeruginosa colonization/infection in patients hospitalized in intensive care units. 相似文献
152.
Dominique Rey Maria-Patrizia Carrieri Bruno Spire Sandrine Loubière Pierre Dellamonica Hervé Gallais Gilles-Patrice Cassuto Jean-Albert Gastaut Yolande Obadia the MANIF Study Group 《Journal of urban health》2004,81(1):48-57
The last international consensus conference about hepatitis C virus (HCV) treatment emphasized the importance of treatment
for persons coinfected with HCV and human immunodeficiency virus (HIV). As liver biopsy precedes treatment, we aimed to identify
factors associated with the performance of liver biopsy among HIV-HCV coinfected drug users during a 5-year follow-up to study
their access to HCV treatment. Of the 296 patients followed in the HIV hospital departments of Nice and Marseilles and with
retrievable records about HCV diagnosis and care, 166 were eligible for analysis having had detectable HCV RNA at least once
during the study period. Overall, 45.2% of patients underwent liver biopsy during follow-up. Using proportional hazard models,
predictors of having had a liver biopsy were high social support, complete abstinence from drug injection, and lack of immunosuppression
as well as male gender, no history of multiple incarcerations, more recent onset of drug use, and an increase of liver enzyme
levels. These results suggest that specific efforts should be devoted to HIV-HCV coinfected drug users to assist with stabilizing
these patients to optimize their access to HCV care whenever possible.
The MANIF 2000 study group includes C. Boirot, A. D. Bouhnik, M. P. Carrieri, J. P. Cassuto, M. Chesney, P. Dellamonica, P.
Dujardin, S. Duran, J. G. Fuzibet, H. Gallais, J. A. Gastaut, G. Lepeu, D. A. Loundou, C. Marimoutou, D. Mechali, J. P. Moatti,
J. Moreau, M. Nègre, Y. Obadia, I. Poizot-Martin, C. Pradier, D. Rey, C. Rouzioux, A. Sobel, B. Spire, F. Trémolières, and
D. Vlahov. 相似文献
153.
Michel Ducreux Marc Ychou Agnès Laplanche Erick Gamelin Philippe Lasser Fares Husseini Fran?ois Quenet Frédéric Viret Jacques-Henri Jacob Valérie Boige Dominique Elias Jean-Robert Delperro Monique Luboinski 《Journal of clinical oncology》2005,23(22):4881-4887
PURPOSE: Isolated hepatic metastases of colorectal cancer constitute a frequent and serious therapeutic problem that has led to the evaluation of hepatic arterial infusion (HAI) of different drugs. Oxaliplatin combined with fluorouracil (FU) and leucovorin is effective in the treatment of colorectal cancer. In this context, a phase II study was conducted to evaluate concomitant administration of oxaliplatin by HAI and intravenous (IV) FU plus leucovorin according to the LV5FU2 protocol (leucovorin 200 mg/m(2), FU 400 mg/m(2) IV bolus, FU 600 mg/m(2) 22-hour continuous infusion on days 1 and 2 every 2 weeks). PATIENTS AND METHODS: Patients had metastatic colorectal cancer that was restricted to the liver and inoperable. The patients were not to have previously received oxaliplatin. After surgical insertion of a catheter in the hepatic artery, patients were treated with oxaliplatin 100 mg/m(2) HAI combined with FU + leucovorin IV according to the LV5FU2 protocol. Treatment was continued until disease progression or toxicity. Response was evaluated every 2 months. RESULTS: Twenty-eight patients were included, and 26 patients were treated. Two hundred courses of therapy were administered, and the median number of courses received was eight courses (range, zero to 20 courses). The most frequent toxicity consisted of neutropenia. The main toxicity related to HAI was pain. The intent-to-treat objective response rate was 64% (95% CI, 44% to 81%; 18 of 28 patients). With a median follow-up of 23 months, the median overall and disease-free survival times were 27 and 27 months, respectively. CONCLUSION: The combination of oxaliplatin HAI and FU + leucovorin according to the LV5FU2 protocol is feasible and effective in patients presenting with isolated hepatic metastases of colorectal cancer. 相似文献
154.
Early variations of circulating interleukin-6 and interleukin-10 levels during thoracic radiotherapy are predictive for radiation pneumonitis. 总被引:5,自引:0,他引:5
Dominique Arpin David Perol Jean-Yves Blay Lionel Falchero Line Claude Sylvie Vuillermoz-Blas Isabelle Martel-Lafay Chantal Ginestet Laurent Alberti Dimitri Nosov Bénédicte Etienne-Mastroianni Vincent Cottin Maurice Perol Jean-Claude Guerin Jean-Fran?ois Cordier Christian Carrie 《Journal of clinical oncology》2005,23(34):8748-8756
PURPOSE: To investigate variations of circulating serum levels of interleukin-6 (IL-6), tumor necrosis factor alpha (TNFalpha), and interleukin-10 (IL-10) during three-dimensional conformal radiation therapy (3D-CRT) in patients with non-small-cell lung cancer and correlate these variations with the occurrence of radiation pneumonitis. PATIENTS AND METHODS: Ninety-six patients receiving 3D-CRT for stage I to III disease were evaluated prospectively. Circulating cytokine levels were determined before, every 2 weeks during, and at the end of treatment. Radiation pneumonitis was evaluated prospectively between 6 and 8 weeks after 3D-CRT. The predictive value of clinical, dosimetric, and biologic (cytokine levels) factors was evaluated both in univariate and multivariate analyses. RESULTS: Forty patients (44%) experienced score 1 or more radiation pneumonitis. No association was found between baseline cytokine levels and the risk of radiation pneumonitis. In the whole population, mean levels of TNFalpha, IL-6, and IL-10 remained stable during radiotherapy. IL-6 levels were significantly higher (P = .047) during 3D-CRT in patients with radiation pneumonitis. In the multivariate analysis, covariations of IL-6 and IL-10 levels during the first 2 weeks of 3D-CRT were evidenced as independently predictive of radiation pneumonitis in this series (P = .011). CONCLUSION: Early variations of circulating IL-6 and IL-10 levels during 3D-CRT are significantly associated with the risk of radiation pneumonitis. Variations of circulating IL-6 and IL-10 levels during 3D-CRT may serve as independent predictive factors for this complication. 相似文献
155.
156.
Laurence Veracini Dominique Grall Sébastien Schaub Stéphanie Beghelli-de la Forest Divonne Marie-Christine Etienne-Grimaldi Gérard Milano Alexandre Bozec Emmanuel Babin Anne Sudaka Juliette Thariat Ellen Van Obberghen-Schilling 《Oncotarget》2015,6(10):7570-7583
EGF receptor (EGFR) overexpression is thought to drive head and neck carcinogenesis however clinical responses to EGFR-targeting agents have been modest and alternate targets are actively sought to improve results. Src family kinases (SFKs), reported to act downstream of EGFR are among the alternative targets for which increased expression or activity in epithelial tumors is commonly associated to the dissolution of E-cadherin-based junctions and acquisition of a mesenchymal-like phenotype. Robust expression of total and activated Src was observed in advanced stage head and neck tumors (N=60) and in head and neck squamous cell carcinoma lines. In cultured cancer cells Src co-localized with E-cadherin in cell-cell junctions and its phosphorylation on Y419 was both constitutive and independent of EGFR activation. Selective inhibition of SFKs with SU6656 delocalized E-cadherin and disrupted cellular junctions without affecting E-cadherin expression and this effect was phenocopied by knockdown of Src or Yes. These findings reveal an EGFR-independent role for SFKs in the maintenance of intercellular junctions, which likely contributes to the cohesive invasion E-cadherin-positive cells in advanced tumors. Further, they highlight the need for a deeper comprehension of molecular pathways that drive collective cell invasion, in absence of mesenchymal transition, in order to combat tumor spread. 相似文献
157.
158.
Association of MICA‐129 polymorphism and circulating soluble MICA level with rheumatoid arthritis in a south Indian Tamil population 下载免费PDF全文
159.
Alban‐Elouen Baruteau MD Raphaël Pedro Martins MD Dominique Boulmier MD Adeline Basquin MD David Briard MD Virginie Gandemer MD Jean‐Marc Schleich MD PhD 《Congenital heart disease》2012,7(1):76-79
A 9‐year‐old black African boy was hospitalized for heart failure revealing a severe left ventricular dysfunction associated with dilated cardiomyopathy, two submitral aneurysms, occlusion of the circumflex artery and a giant coronary artery aneurysm on the proximal left anterior descending artery. The boy was coinfected with human immunodeficiency virus and Mycobacterium tuberculosis. Though rare, association of Takayasu arteritis and submitral aneurysm leads to rethinking the pathogenesis of submitral aneurysm and suggests that some of them may be acquired. In our case, a common inflammatory process, possibly triggered by tuberculosis or HIV, may underlie Takayasu and submitral aneurysms. 相似文献
160.