全文获取类型
收费全文 | 3283篇 |
免费 | 231篇 |
国内免费 | 17篇 |
专业分类
耳鼻咽喉 | 58篇 |
儿科学 | 58篇 |
妇产科学 | 48篇 |
基础医学 | 488篇 |
口腔科学 | 80篇 |
临床医学 | 328篇 |
内科学 | 731篇 |
皮肤病学 | 34篇 |
神经病学 | 312篇 |
特种医学 | 248篇 |
外科学 | 546篇 |
综合类 | 12篇 |
一般理论 | 1篇 |
预防医学 | 163篇 |
眼科学 | 40篇 |
药学 | 177篇 |
中国医学 | 9篇 |
肿瘤学 | 198篇 |
出版年
2023年 | 39篇 |
2022年 | 131篇 |
2021年 | 189篇 |
2020年 | 107篇 |
2019年 | 130篇 |
2018年 | 134篇 |
2017年 | 91篇 |
2016年 | 117篇 |
2015年 | 138篇 |
2014年 | 160篇 |
2013年 | 183篇 |
2012年 | 265篇 |
2011年 | 263篇 |
2010年 | 116篇 |
2009年 | 107篇 |
2008年 | 196篇 |
2007年 | 169篇 |
2006年 | 161篇 |
2005年 | 149篇 |
2004年 | 120篇 |
2003年 | 112篇 |
2002年 | 106篇 |
2001年 | 24篇 |
2000年 | 30篇 |
1999年 | 30篇 |
1998年 | 13篇 |
1997年 | 7篇 |
1996年 | 14篇 |
1995年 | 7篇 |
1993年 | 7篇 |
1992年 | 13篇 |
1991年 | 14篇 |
1990年 | 14篇 |
1989年 | 14篇 |
1988年 | 6篇 |
1987年 | 14篇 |
1986年 | 7篇 |
1985年 | 9篇 |
1984年 | 7篇 |
1983年 | 5篇 |
1979年 | 7篇 |
1978年 | 6篇 |
1977年 | 11篇 |
1974年 | 9篇 |
1972年 | 4篇 |
1971年 | 7篇 |
1970年 | 9篇 |
1969年 | 9篇 |
1967年 | 4篇 |
1966年 | 4篇 |
排序方式: 共有3531条查询结果,搜索用时 15 毫秒
51.
Barbara Fumić Jasna Jablan Dominik Cinčić Marijana Zovko Končić 《Journal of microencapsulation》2018,35(1):1-12
This work aimed to investigate the potential effect of cyclodextrin encapsulation on intrinsic ability of daidzein (DAD) and genistein (GEN) to inhibit the glycosaminoglycan (GAG) synthesis in fibroblasts originating from patients with mucopolysaccharidosis (MPS), type II and III. DAD or GEN encapsulation with either 2-hydroxypropyl-β-cyclodextrin or sulphobuthylether-β-cyclodextrin were achieved by neat grinding and were characterised by thermal analysis, X-ray powder diffraction, scanning electron microscopy and solubility testing which confirmed the complexes formation with increased solubility with respect to starting compounds. Both isoflavones, as well as their co-ground cyclodextrin complexes reduced GAG levels in the fibroblasts of MPS II and MPS III patients from 54.8–77.5%, in a dose dependent manner, without any significant cytotoxic effect. Cyclodextrin encapsulation did not change the intrinsically high effect of both DAD and GEN on the GAG level reduction in the treated cells, thus could be considered as a part of combination therapies of MPS. 相似文献
52.
Guy Laureys Barbara Willekens Ludo Vanopdenbosch Olivier Deryck Dominik Selleslag Miguel D’Haeseleer Ann De Becker Bénédicte Dubois Daan Dierickx Gaetano Perrotta Virginie De Wilde Vincent van Pesch Nicole Straetmans Dominique Dive Yves Beguin Bart Van Wijmeersch Koen Theunissen Tessa Kerre Ann Van de Velde 《Acta neurologica Belgica》2018,118(2):161-168
Multiple sclerosis is considered to be an immune mediated inflammatory disorder of the central nervous system. It mainly affects young, socioeconomic active patients. Although our armamentarium for this disease has significantly evolved in recent years some patients remain refractory to conventional therapies. In these cases, autologous hematopoietic stem cell transplantation can be considered as a therapeutic option. Decreasing morbidity, mortality, and increasing patient awareness have led to rising inquiry by our patients about this treatment option. With the aim of a standardized protocol and data registration, a Belgian working party on stem cell therapy in multiple sclerosis was established. In this paper, we report the consensus protocol of this working party on autologous hematopoietic stem cell transplantation in multiple sclerosis. 相似文献
53.
Coordes Stefanie Louise Jost-Brinkmann Paul-Georg Präger Thomas Michael Bartzela Theodosia Visel Dominik Jäcker Theresa Müller-Hartwich Ralf 《Journal of orofacial orthopedics》2018,79(1):49-56
Journal of Orofacial Orthopedics / Fortschritte der Kieferorthopädie - Aim of the study was to compare how six different sealants resisted thermal, mechanical, and chemical loading in vitro.... 相似文献
54.
Dominik Schori Matthias Jaeger Timon Elmer Susanne Jaeger Candelaria Mahlke Kolja Heumann Anastasia Theodoridou Gianfranco Zuaboni Bernd Kozel Franziska Rabenschlag 《Archives of Psychiatric Nursing》2018,32(5):662-669
Treatment pressure restricts patients' voluntary and autonomous decisions. Yet interventions involving treatment pressure are widely used in mental health and psychosocial services. This cross-sectional study explored whether mental health professionals' knowledge on five types of treatment pressure (no coercion, persuasion or conviction, leverage, threat, and formal coercion) was associated with sociodemographic, professional and contextual factors. A more positive attitude towards interventions involving treatment pressure was associated with underrating the level of those interventions compared with a predefined default value. The treatment setting and professional group played a minor role in ‘leverage’ and ‘formal coercion’ types of treatment pressure, respectively. 相似文献
55.
56.
Sebastian Czaplinski Behnaz Ahangarian Abhari Alica Torkov Dominik SeggewiΔ Manuela Hugle Simone Fulda 《Oncotarget》2015,6(39):41522-41534
We explored the potential of Smac mimetics, which antagonize Inhibitor of Apoptosis (IAP) proteins, for chemosensitization of neuroblastoma (NB). Here, we report that Smac mimetics, e.g. BV6, prime NB cells for chemotherapeutics including the topoisomerase II inhibitor doxorubicin (DOX) and vinca alkaloids such as Vincristine (VCR), Vinblastine (VBL) and Vinorelbine (VNR). Additionally, BV6 acts in concert with DOX or VCR to suppress long-term clonogenic growth. While BV6 causes rapid downregulation of cellular IAP (cIAP)1 protein and nuclear factor-kappaB (NF-κB) activation, DOX/BV6- or VCR/BV6-induced apoptosis occurs independently of NF-κB or TNFα signaling, since overexpression of dominant-negative IκBα superrepressor or the Tumor Necrosis Factor (TNF)α-blocking antibody Enbrel fail to block cell death. Mechanistic studies reveal that Receptor-interacting protein (RIP)1 is required for DOX/BV6-, but not for VCR/BV6-induced apoptosis, since transient or stable knockdown of RIP1 or the pharmacological RIP1 inhibitor necrostatin-1 significantly reduce apoptosis. By comparison, VCR/BV6-mediated apoptosis critically depends on the mitochondrial pathway. VCR/BV6 cotreatment causes phosphorylation of BCL-2 during mitotic arrest, enhanced activation of BAX and BAK and loss of mitochondrial membrane potential (MMP). Additionally, overexpression of BCL-2 profoundly suppresses VCR/BV6-induced apoptosis. Thus, BV6 sensitizes NB cells to chemotherapy-induced apoptosis via distinct initial signaling mechanisms depending on the chemotherapeutic drug. These findings provide novel mechanistic insights into Smac mimetic-mediated chemosensitization of NB. 相似文献
57.
58.
59.
60.