首页 | 本学科首页   官方微博 | 高级检索  
文章检索
  按 检索   检索词:      
出版年份:   被引次数:   他引次数: 提示:输入*表示无穷大
  收费全文   136篇
  免费   5篇
耳鼻咽喉   2篇
儿科学   12篇
妇产科学   6篇
基础医学   14篇
口腔科学   2篇
临床医学   14篇
内科学   26篇
皮肤病学   10篇
神经病学   6篇
外科学   7篇
综合类   3篇
预防医学   14篇
眼科学   6篇
药学   13篇
肿瘤学   6篇
  2023年   2篇
  2022年   6篇
  2021年   11篇
  2020年   3篇
  2019年   5篇
  2018年   5篇
  2017年   1篇
  2016年   3篇
  2015年   3篇
  2014年   7篇
  2013年   8篇
  2012年   16篇
  2011年   9篇
  2010年   11篇
  2009年   5篇
  2008年   5篇
  2007年   11篇
  2006年   5篇
  2005年   9篇
  2004年   4篇
  2003年   3篇
  2002年   4篇
  1996年   2篇
  1995年   2篇
  1981年   1篇
排序方式: 共有141条查询结果,搜索用时 15 毫秒
71.
Several papers have recently addressed the issue of estimating chromophore concentration in optoacoustic imaging (OAI) using multiple wavelengths. The choice of wavelengths obviously affects the accuracy and precision of the estimates. One might assume that the wavelengths that maximize the extinction coefficients of the chromophores would be the most suitable. However, this may not always be the case since the distribution of light intensity in the medium is also wavelength dependent. In this paper, we explore a method for optimizing the choice of wavelengths based on the Cramer-Rao lower bound (CRLB) on the variance of the chromophore concentration. This lower bound on variance can be evaluated numerically for different wavelengths using the variation of the extinction coefficients and scattering coefficients with wavelength. The wavelengths that give the smallest variance will be considered optimal for multi-wavelength OAI to estimate the chromophore concentrations. The expression for the CRLB has been derived analytically for estimating the concentration of multiple chromophores for several simple phantom models for the case when the optoacoustic signal is proportional to the product of the optical absorption and the illumination function. This approach could be easily extended to other geometries.  相似文献   
72.
73.

Background

A high level of knowledge about Tuberculosis amongst the Multi-Purpose Workers (MPWs) is the cornerstone for the successful implementation of Directly Observed Treatment Short-course (DOTS) strategy under the Revised National Tuberculosis control Programme of India. In this regard, the evaluation of MPWs, the major workforce of the Health Department of Solan district, has never been done in the past. Hence the present study was undertaken.

Methods

Objective: To evaluate the knowledge about Tuberculosis among the MPW DOT and non DOT Providers.

Design

A cross sectional study amongst 174 MPWs of the five Tubercular Units was conducted.Informed written consent was obtained. A pretested self-administered questionnaire was used.Data was analyzed in Microsoft Excel 2010 and IBM SPSS statistics version 21 software.

Results

85.6 per cent of the study participants were or had been DOT Providers. Only 9.2 per cent of the workers had received RNTCP Modular training whereas, 87.4 per cent had received just the ‘On the Spot training’ about DOTS. The difference in knowledge by Gender distribution across the five TUs was found significant.

Conclusion

There is inadequate knowledge of tuberculosis amongst the MPW DOT and Non DOT Providers. Hence regular Modular and refresher trainings are recommended.  相似文献   
74.
Chronic cutaneous ulcers, a complex pathophysiological diabetic condition, represent a critical clinical challenge in the current diabetes mellitus pandemic. Consequently, there is a compelling need for bioactive dressings that can trigger healing processes for complete wound repair. Silk fibroin (SF), a natural protein polymer from mulberry and non‐mulberry silkworms, has properties that support accelerated wound healing rate. SF from non‐mulberry variety possesses additional cell‐binding motifs (arginine, glycine, and aspartate), offering cell–material interactions. This study is aimed to investigate wound healing efficacy of dressings made up of various SF varieties blended with poly(vinyl alcohol) biopolymer in alloxan‐induced diabetic rabbit model. The nanofibrous mats have been developed using electrospinning and functionalized with growth factors and LL‐37 antimicrobial peptide for sustained delivery. Following post 14‐day treatment, non‐mulberry SF (NMSF)‐based dressings healed the wounds faster, in comparison with their mulberry Bombyx mori SF, poly(vinyl alcohol), and control counterparts (p < .01). NMSF‐based dressings also supported faster granulation tissue development, angiogenesis, and reepithelialization of wounds. Gene expression study of matrix metalloproteinases and collagen proteins affirmed higher extent of tissue remodelling during the repair process. Furthermore, there was organized extracellular matrix deposition (collagen type I, collagen type III, elastin, and reticulin) and higher wound breaking strength in NMSF compared with other groups after 4 weeks. These results validated the potential of NMSF‐based bioactive dressings to regulate extracellular matrix deposition leading to faster and complete repair of chronic diabetic cutaneous wounds.  相似文献   
75.
PurposeThe purpose of this study is to evaluate (1) the predictive value of fetal bowel dilatation (FBD) for intestinal atresia in gastroschisis and (2) the postnatal management and outcome of this condition.MethodsA retrospective review of all gastroschisis cases diagnosed in our fetal medicine unit between 1992 and 2010 and treated postnatally in our center was performed.ResultsOne hundred thirty cases had full postnatal data available. Intestinal atresia was found at surgery in 14 neonates (jejunum, n = 6; ileum, n = 3; ascending colon, n = 3; multiple, n = 2). Polyhydramnios and FBD were more likely in the atresia group compared with infants with no atresia (P = .0003 and P = .005, respectively). Fetal bowel dilatation had 99% negative predictive value (95% confidence interval, 0.9-0.99) and 17% positive predictive value (95% confidence interval, 0.1-0.3) for atresia. Treatment of intestinal atresia included primary anastomosis (n = 5), delayed anastomosis (n = 2), and stoma formation followed by anastomosis (n = 7). Infants with atresia had longer duration of parenteral nutrition, higher incidence of sepsis, and cholestasis compared with infants with no atresia (P = .0003). However, the presence of atresia did not increase mortality.ConclusionsPolyhydramnios and FBD are associated with atresia. Absence of FBD in gastroschisis excludes intestinal atresia. In our experience, atresia is associated with a longer duration of parenteral nutrition but does not influence mortality. These findings may be relevant for antenatal counseling.  相似文献   
76.
Proceedings of the National Academy of Sciences, India Section B: Biological Sciences - The present investigation has been an attempt to evaluate antifungal and antioxidant potential of two ethno...  相似文献   
77.
Background: Children who are taller for their age tend to have higher BMI and, as a group, a greater prevalence of overweight/obesity.

Aim: To examine the relationship between height for age with three measures of adiposity.

Subjects and methods: Height, weight, BMI, % body fat (%BF) (by bioimpedance) and waist circumference (WC) were measured in 2298 Caucasian children (1251 boys) aged 4–14 years. Standard deviation scores (SDS) were derived and cases divided into quartiles of height SDS. Mean BMI, %BF and WC SDSs were compared across quartiles. Prevalence of overweight/obesity, over-fat/obesity and abdominal overweight/obesity within each height for age quartile was determined.

Results: Mean BMI, %BF and WC SDSs increased with increasing quartile of height SDS. Overweight/obesity, overfat/obesity and abdominal overweight/obesity prevalence increased from the first quartile (8.8–13%) to the fourth quartile (32.7–45.5%) of height SDS. A significant rising trend in mean SDSs for BMI, %BF and WC was also observed with increasing height SDS in overweight/obese children only.

Conclusion: A higher prevalence of excess weight, measured by BMI SDS among children taller for their age, is replicated when using %BF and WC. Height for age measurement has potential in screening children for later risk of obesity.  相似文献   

78.
ObjectiveAge-standardized burden of cardiovascular diseases is substantially higher in low and middle-income countries than in high-income countries. However, Indian patients are not getting access to the new cardiovascular drugs at the same time as patients in the developed nations. The objective of this study was to assess the drug lag for new cardiovascular drugs in India compared with that in the United States (US) or European Union (EU).MethodsThe information regarding approval of new cardiovascular drugs in the United States, European Union and India between 1999 and 2011 were obtained primarily from the online databases of regulatory agencies. The approval lag was obtained for all new cardiovascular drugs approved in each region, and the median approval lag was calculated for each region.ResultsOf the 75 new cardiovascular drugs, 61 (81.33%) were approved in the United States, 65 (86.66%) in the European Union and 56 (74.66%) in India. The US was the first to approve 35 (56.45%) out of the 75 new cardiovascular drugs, the EU was the first to approve 24 (38.71%) and India was the first to approve 3 (4.84%). The median approval lag for India (44.14 months) was substantially higher as compared to the United States (0 month) and European Union (2.99 months).ConclusionThis study confirms that there is a substantial drug lag in approval of new cardiovascular drugs in India compared with the United States and European Union. The impact of drug lag on health outcomes remains to be established.  相似文献   
79.
The emergence of Hendra Virus (HeV) and Nipah Virus (NiV) which can cause fatal infections in both animals and humans has triggered a search for an effective vaccine. Here, we have explored the potential for generating an effective humoral immune response to these zoonotic pathogens using an alphavirus-based vaccine platform. Groups of mice were immunized with Venezuelan equine encephalitis virus replicon particles (VRPs) encoding the attachment or fusion glycoproteins of either HeV or NiV. We demonstrate the induction of highly potent cross-reactive neutralizing antibodies to both viruses using this approach. Preliminary study suggested early enhancement in the antibody response with use of a modified version of VRP. Overall, these data suggest that the use of an alphavirus-derived vaccine platform might serve as a viable approach for the development of an effective vaccine against the henipaviruses.  相似文献   
80.
Levothyroxine (T4) is a narrow therapeutic index drug with classic bioequivalence problem between various available products. Dissolution of a drug is a crucial step in its oral absorption and bioavailability. The dissolution of T4 from three commercial solid oral dosage forms: Synthroid® (SYN), generic levothyroxine sodium by Sandoz Inc. (GEN) and Tirosint® (TIR) was studied using a sensitive ICP-MS assay. All the three products showed variable and pH-dependent dissolution behaviors. The absence of surfactant from the dissolution media decreased the percent T4 dissolved for all the three products by 26-95% (at 30 min). SYN dissolution showed the most pH dependency, whereas GEN and TIR showed the fastest and highest dissolution, respectively. TIR was the most consistent one, and was minimally affected by pH and/or by the presence of surfactant. Furthermore, dissolution of T4 decreased considerably with increase in the pH, which suggests a possible physical interaction in patients concurrently on T4 and gastric pH altering drugs, such as proton pump inhibitors. Variable dissolution of T4 products can, therefore, impact the oral absorption and bioavailability of T4 and may result in bioequivalence problems between various available products.  相似文献   
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号