Meizi Eliezer  Anton Sculean  Richard J. Miron  Carlos Nemcovsky  Evegeny Weinberg  Miron Weinreb  Hasan Zoabi  Dieter D. Bosshardt  Masako Fujioka‐Kobayashi  Ofer Moses 《Journal of periodontal research》2019,54(6):644-652

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Luiz A. Lima  Dieter D. Bosshardt  Leandro Chambrone  Mauricio G. Araújo  Niklaus P. Lang 《Clinical oral implants research》2019,30(11):1142-1154

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Matthias Kls  Loreen Thürmann  Mario Bauer  Joachim Heinrich  Marie Standl  Andrea von Berg  Beate Schaaf  Dieter Weichenhan  Oliver Mücke  Christoph Plass  Stefan Rder  Gunda Herberth  Ulrich Sack  Michael Borte  Gabriele I. Stangl  Roland Eils  Saskia Trump  Irina Lehmann 《Allergy》2019,74(10):2002-2006

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Laura Palagini  Celyne H. Bastien  Donatella Marazziti  Jason G. Ellis  Dieter Riemann 《Journal of sleep research》2019,28(6)

Mood disorders are amongst the most prevalent and severe disorders worldwide, with a tendency to be recurrent and disabling. Although multiple mechanisms have been hypothesized to be involved in their pathogenesis, just a few integrative theoretical frameworks have been proposed and have yet to integrate comprehensively all available findings. As such, a comprehensive framework would be quite useful from a clinical and therapeutic point of view in order to identify elements to evaluate and target in the clinical practice. Because conditions of sleep loss, which include reduced sleep duration and insomnia, are constant alterations in mood disorders, the aim of this paper was to review the literature on their potential role in the pathogenesis of mood disorders and to propose a novel theoretical model. According to this hypothesis, sleep should be considered the main regulator of several systems and processes whose dysregulation is involved in the pathogenesis of mood disorders. The model may help explain why sleep disturbances are so strikingly linked to mood disorders, and underscores the need to evaluate, assess and target sleep disturbances in clinical practice, as a priority, in order to prevent and treat mood disorders.  相似文献   

    

Katrin Schmitt  Britta Molfenter  Natalia Koerich Laureano  Bouchra Tawk  Matthias Bieg  Xavier Pastor Hostench  Dieter Weichenhan  Nina D. Ullrich  Viny Shang  Daniela Richter  Fabian Stögbauer  Lea Schroeder  Bianca de Bem Prunes  Fernanda Visioli  Pantelis Varvaki Rados  Adriana Jou  Michaela Plath  Philippe A. Federspil  Julia Thierauf  Johannes Döscher  Stephanie E. Weissinger  Thomas K. Hoffmann  Steffen Wagner  Claus Wittekindt  Naveed Ishaque  Roland Eils  Jens P. Klussmann  Dana Holzinger  Christoph Plass  Amir Abdollahi  Kolja Freier  Wilko Weichert  Karim Zaoui  Jochen Hess 《International journal of cancer. Journal international du cancer》2019,145(12):3299-3310

Genomic sequencing projects unraveled the mutational landscape of head and neck squamous cell carcinoma (HNSCC) and provided a comprehensive catalog of somatic mutations. However, the limited number of significant cancer-related genes obtained so far only partially explains the biological complexity of HNSCC and hampers the development of novel diagnostic biomarkers and therapeutic targets. We pursued a multiscale omics approach based on whole-exome sequencing, global DNA methylation and gene expression profiling data derived from tumor samples of the HIPO-HNC cohort (n = 87), and confirmed new findings with datasets from The Cancer Genome Atlas (TCGA). Promoter methylation was confirmed by MassARRAY analysis and protein expression was assessed by immunohistochemistry and immunofluorescence staining. We discovered a set of cancer-related genes with frequent somatic mutations and high frequency of promoter methylation. This included the ryanodine receptor 2 (RYR2), which showed variable promoter methylation and expression in both tumor samples and cell lines. Immunohistochemical staining of tissue sections unraveled a gradual loss of RYR2 expression from normal mucosa via dysplastic lesion to invasive cancer and indicated that reduced RYR2 expression in adjacent tissue and precancerous lesions might serve as risk factor for unfavorable prognosis and upcoming malignant conversion. In summary, our data indicate that impaired RYR2 function by either somatic mutation or epigenetic silencing is a common event in HNSCC pathogenesis. Detection of RYR2 expression and/or promoter methylation might enable risk assessment for malignant conversion of dysplastic lesions.  相似文献   

    

Lowell B. Anthony  Matthew H. Kulke  Martyn E. Caplin  Emily Bergsland  Kjell Öberg  Marianne Pavel  Dieter Hörsch  Richard R.P. Warner  Thomas M. O'Dorisio  Joseph S. Dillon  Pablo Lapuerta  Kenneth Kassler-Taub  Wenjun Jiang 《The oncologist》2019,24(8):e662-e670

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Kari Anne I. Evensen  Marjaana Tikanmki  Kati Heinonen  Hanna‐Maria Matinolli  Marika Sipola‐Leppnen  Aulikki Lano  Dieter Wolke  Marja Vrsmki  Johan G. Eriksson  Sture Andersson  Marjo‐Riitta Jrvelin  Petteri Hovi  Katri Rikknen  Eero Kajantie 《European Journal of Pain》2019,23(3):461-471

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David Steinebrunner  Günter Schnurpfeil  Dieter Whrle  Arne Wittstock 《RSC advances》2019,10(1):53

A series of singlet oxygen sensitizing hybrid materials is reported consisting of a zinc(ii) phthalocyanine (ZnPc) derivative immobilized on nanoporous gold leafs (npAu) with various pore sizes. The resulting photocatalytic coatings exhibit a thickness of around 100 nm and pore sizes between 9–50 nm. Herein, we report the synthesis and characterization of those hybrid materials which were synthesized by functionalization of npAu leafs by an azide terminated alkanethiol self-assembled monolayer (SAM) and subsequent copper catalyzed azide–alkyne cycloaddition (CuAAC). The characterization of the samples morphology included scanning electron microscopy (SEM), UV-Vis spectroscopy as well as energy dispersive X-ray spectroscopy (EDX). The morphology–reactivity relationship was investigated employing the hybrid photocatalysts in the photooxidation of diphenylisobenzofuran (DPBF) as selective singlet oxygen quencher. An increasing photocatalytic activity was found for smaller pore sizes up to 15 nm, due to the gain in specific surface area concomitant with an increasing amount of immobilized photosensitizer, completely dominating the effect of the higher spectral overlap caused by the shift of the plasmon resonance of npAu, until mass transport and diffusion limitation gets predominant for pore sizes below 15 nm.

A series of hybrid materials consisting of a zinc(ii) phthalocyanine derivative immobilized on nanoporous gold leafs with various pore sizes was prepared and investigated regarding its singlet oxygen sensitization activity.  相似文献   

    

Linda D Breeman  Julia Jaekel  Nicole Baumann  Peter Bartmann  Dieter Wolke 《Developmental medicine and child neurology》2017,59(5):477-483

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Yoshinori Shirakata  Richard J. Miron  Toshiaki Nakamura  Kotaro Sena  Yukiya Shinohara  Naoto Horai  Dieter D. Bosshardt  Kazuyuki Noguchi  Anton Sculean 《Journal of clinical periodontology》2017,44(3):298-307

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