全文获取类型
收费全文 | 51097篇 |
免费 | 3214篇 |
国内免费 | 116篇 |
专业分类
耳鼻咽喉 | 714篇 |
儿科学 | 2545篇 |
妇产科学 | 1296篇 |
基础医学 | 6054篇 |
口腔科学 | 2043篇 |
临床医学 | 4786篇 |
内科学 | 11212篇 |
皮肤病学 | 1277篇 |
神经病学 | 4254篇 |
特种医学 | 1625篇 |
外国民族医学 | 5篇 |
外科学 | 7567篇 |
综合类 | 418篇 |
一般理论 | 19篇 |
预防医学 | 3439篇 |
眼科学 | 1161篇 |
药学 | 3175篇 |
中国医学 | 229篇 |
肿瘤学 | 2608篇 |
出版年
2024年 | 39篇 |
2023年 | 408篇 |
2022年 | 309篇 |
2021年 | 924篇 |
2020年 | 604篇 |
2019年 | 919篇 |
2018年 | 1608篇 |
2017年 | 1158篇 |
2016年 | 1221篇 |
2015年 | 1139篇 |
2014年 | 1322篇 |
2013年 | 2292篇 |
2012年 | 3711篇 |
2011年 | 4301篇 |
2010年 | 1904篇 |
2009年 | 1255篇 |
2008年 | 3613篇 |
2007年 | 3907篇 |
2006年 | 3723篇 |
2005年 | 3771篇 |
2004年 | 3655篇 |
2003年 | 3447篇 |
2002年 | 3215篇 |
2001年 | 1179篇 |
2000年 | 1102篇 |
1999年 | 700篇 |
1998年 | 417篇 |
1997年 | 268篇 |
1996年 | 250篇 |
1995年 | 215篇 |
1994年 | 188篇 |
1993年 | 143篇 |
1992年 | 140篇 |
1991年 | 129篇 |
1990年 | 136篇 |
1989年 | 103篇 |
1988年 | 100篇 |
1987年 | 92篇 |
1986年 | 79篇 |
1985年 | 68篇 |
1984年 | 71篇 |
1983年 | 57篇 |
1982年 | 66篇 |
1981年 | 55篇 |
1980年 | 46篇 |
1979年 | 43篇 |
1978年 | 39篇 |
1977年 | 44篇 |
1976年 | 23篇 |
1973年 | 33篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
101.
Solish Nowell MD Benohanian Antranik MD Jonathan W. Kowalski PharmD MS on Behalf of the Canadian Dermatology Study Group on Health-Related Quality of Life in Primary Axillary Hyperhidrosis 《Dermatologic surgery》2005,31(4):405-413
BACKGROUND: Patients with primary axillary hyperhidrosis experience substantial functional impairment and reduced health-related quality of life (HRQOL). Few studies have comprehensively evaluated the effects of botulinum toxin type A (BoNT-A) on these symptoms. OBJECTIVE: To prospectively assess the effects of BoNT-A on functional impairment associated with primary axillary hyperhidrosis. METHODS: Patients treated with BoNT-A 50 U per axilla at baseline were assessed 4 and 12 weeks later. Outcome measures included functional impairment as assessed by the Hyperhidrosis Disease Severity Scale and the Hyperhidrosis Impact Questionnaire and dermatology-specific HRQOL as assessed by the Dermatology Life Quality Index. RESULTS: At weeks 4 and 12 after BoNT-A treatment, 85% and 90% of patients achieved the a priori definition of treatment responder. Patients reported less occupational and emotional impairment, spent less time managing their hyperhidrosis, and had fewer difficulties in social situations. Adverse events were uncommon (5.5%), were mild, and did not require treatment. At study end, 53% of patients reported no dermatology-specific HRQOL impairment and 90% were satisfied with treatment. CONCLUSIONS: Significant, meaningful, rapid, and durable reductions in disease severity and functional impairment, as well as improvements in HRQOL, were seen following BoNT-A treatment. BoNT-A was safe and well tolerated, producing high levels of patient satisfaction. 相似文献
102.
Lipidic nanoparticles (NP), formulated from a phase inversion temperature process, have been studied with chemometric techniques to emphasize the influence of the four major components (Solutol®, Labrasol®, Labrafac®, water) on their average diameter and their distribution in size. Typically, these NP present a monodisperse size lower than 200 nm, as determined by dynamic light scattering measurements. From the application of the partial least squares (PLS) regression technique to the experimental data collected during definition of the feasibility zone, it was established that NP present a core-shell structure where Labrasol® is well encapsulated and contributes to the structuring of the NP. Even if this solubility enhancer is regarded as a pure surfactant in the literature, it appears that the oil moieties of this macrogolglyceride mixture significantly influence its properties. Furthermore, results have shown that PLS technique can be also used for predictions of sizes for given relative proportions of components and it was established that from a mixture design, the quantitative mixture composition to use in order to reach a targeted size and a targeted polydispersity index (PDI) can be easily predicted. Hence, statistical models can be a useful tool to control and optimize the characteristics in size of NP. ©2010 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 99:4603–4615, 2010 相似文献
103.
104.
105.
A. Barutçu 《European journal of plastic surgery》1994,17(3):118-120
Summary In 1982, Dibbell described a procedure to correct this distortion by rotating and advancing the nostril medially and superiorly. We used this method in our department for several years, but as Dibbell himself experienced, we didn't always obtain satisfactory results. Like many authors, I agree that the best approach for proper correction of the secondary unilateral cleft lip nose deformity is the external approach using transcolumellar incisions, because the lower lateral cartilage exposure is inadequate with Dibbell's method. I added the transcolumellar incision similar to Bardach's to solve this problem. In this paper, this combination technique will be presented and contrasted with Dibbell's and Bardach's techniques. 相似文献
106.
The reactivities of carbaryl, N-methyl 1-naphthylcarbamate insecticide and its N-nitrosated derivative carcinogenic, N-nitrosocarbaryl, were investigated on the microsomal hepatic lipid peroxidation and NADPH-dependent reductase activities. The in vivo treatment by N-nitrosocarbaryl produced a reduction in lipoperoxidative degradation induced in vitro by NADPH with regard to the formation of malonaldehyde and conjugated dienes. Carbaryl, its precursor did not affect lipid peroxidation under the same in vivo conditions. Moreover, following administration of the 2 compounds, the activities of NADPH-cytochrome c reductase as well as NADPH-neotetrazolium reductase were significantly decreased by N-nitrosocarbaryl but not influenced by carbaryl. Correspondingly, in vitro studies were performed; different action patterns of the 2 tested xenobiotics were also noted after treatment of rat liver microsomes in vitro by carbaryl and N-nitrosocarbaryl especially in their ability to cope with microsomal oxygen activation. N-Nitrosocarbaryl proved to have a potent inhibitor concentration effect on NADPH-dependent chemiluminescence response in vitro; carbaryl was virtually ineffective on this parameter. No significant difference appeared in the affinity of N-nitrosocarbaryl and carbaryl for the microsomal phospholipids. From the in vitro explorations, it was suggested that carcinogenic N-nitrosocarbaryl may be involved in the inhibition mechanism of microsomal lipid peroxidation through decreases in both NADPH-dependent reductase activities and superoxide generation. 相似文献
107.
Farida Daïkha-Dahmane Françoise Narcy Marc Dommergues Mireille Lacoste Agnes Beziau Marie-Claire Gubler 《Pediatric nephrology (Berlin, Germany)》1997,11(3):267-273
An alteration in cell/matrix interactions is one of the suggested mechanisms leading to cyst formation in polycystic kidney
diseases. Most of these interactions are mediated by β1-integrins, a subfamily of integrin receptors, formed by the association
of the β1-chain with different α-subunits. To date, no study on α-integrin subunit distribution during the early stages of
cyst development has been reported. Using immunofluorescence, we analyzed the distribution of α-integrin subunits (α1, α2,
α3, α5, and α6) and basement membrane proteins in kidneys of fetuses with autosomal dominant (ADPKD) or autosomal recessive
polycystic kidney disease (ARPKD). The distribution was compared with that observed in normal fetal and post-natal kidneys,
and in fetal cystic dysplasia and Meckel syndrome. Marked increase in α1-integrin staining was observed in normal and cystic
collecting duct cells of both polycystic diseases (PKD), compared with normal and cystic controls. The distribution of integrin
subunits α2, α3, and α6 was irregular in cyst epithelial cells of PKD and cystic controls. The increased expression of the
α1-subunit specifically observed in PKD collecting duct cells may be an early consequence of the genetic defect in ARPKD.
In ADPKD it parallels the reported expression of polycystin, the protein product of PKD1. The irregular expression of α2,
α3, and α6 integrin subunits observed in all types of cysts suggests that cell/matrix interactions are altered early and may
participate in the development of cysts, perhaps by contributing to the deregulation of cell survival in cystic diseases.
Received May 28, 1996; received in revised form October 2, 1996; accepted October 25, 1996 相似文献
108.
A. C. Iplikçioğlu M. A. Bayar F. Kökeş B. Yildiz C. Gökçek Z. Buharali 《Neuroradiology》1994,36(1):31-32
We report a fluid level in an acute extradural haematoma developing after placement of a ventriculoperitoneal shunt for hydrocephalus. This fluid level was thought to be due to a mixture of blood and cerebrospinal fluid. 相似文献
109.
Constantly evolving treatment guidelines based on a growing body of randomized controlled trials are helping us to improve outcomes in sepsis. However, it must be borne in mind that proven benefit from individual sepsis treatments does not guarantee synergistic beneficial effects when new treatments are added to sepsis management. Indeed, unexpected harmful interactions are also possible. A good example of this is the conflict between intensive insulin therapy and 'low dose' hydrocortisone in septic shock. The goal of tight glycaemic control is made more complicated by steroid-induced hyperglycaemia. In their recent study, Loisa and coworkers demonstrate a measure that reduces the risk for this interaction. They found continuous infusion of hydrocortisone to be associated with fewer hyperglycaemic episodes and reduced staff workload compared with bolus application. 相似文献
110.
Laryngeal pleomorphic rhabdomyosarcoma 总被引:2,自引:0,他引:2
M. U. Akyol B. Sözeri T. Küçükali O. Ög˘retmenog˘lu 《European archives of oto-rhino-laryngology》1998,255(6):307-310
A case of an extremely unusual tumor of the larynx, pleomorphic rhabdomyosarcoma, is presented with a review of literature.
This is the fifth case of this malignancy described in the larynx in the English language literature. A histopathological
diagnosis was made with immunohistochemistry and electron microscopy. In contrast to other reported cases, the tumor in the
present case had a very aggressive behavior. Despite radical surgery involving total laryngectomy and neck dissection followed
by radiation therapy, the patient died of disease 8 months following treatment.
Received: 14 March 1997 / Accepted: 23 January 1998 相似文献