Photobiomodulation therapy on expression of HSP70 protein and tissue repair in experimental acute Achilles tendinitis

Lasers in Medical Science - The aim of the present study was to investigate the effects of photobiomodulation (PBM) therapy on the expression of heat shock protein 70 (HSP70) and tissue repair in...     

Antimicrobial photodynamic therapy against Propionibacterium acnes biofilms using hypericin (Hypericum perforatum) photosensitizer: in vitro study

Lasers in Medical Science - Acne vulgaris is the most recurring skin condition in the world, causing great harm to the physical and psychological well-being of many patients. Antimicrobial...     

Racial differences in selection of ideal body size by adolescent females

Cultural differences may partially account for the fact that more black women than white women are overweight in the United States. This study measured perceptions of ideal body size among 93 black and 80 white females, 14-17 years old, who were randomly selected from three public high schools in a southeastern state. The subjects' height and weight were measured along with their estimates of their mother's body size, weight control attitudes, and demographic variables. Blacks preferred a significantly larger body size than whites when asked to select ideal body size (p = 0.045). Subjects who estimated their mother's size to be larger, also selected a larger ideal body size (p = .047). Those who perceived themselves as too fat were more likely to skip meals to help control their weight, compared with those who perceived themselves as normal or too thin (p = .003). Approximately 30% of the sample was overweight or obese. There were not significant racial differences in weight or BMI. These results suggest that overweight is more acceptable among black females than among white females and may help explain why more black females are obese.     

Ascaris–Trichuris association and malnutrition in Brazilian children

This work was designed to evaluate the role of intestinal parasites on nutritional status in three rural areas of Brazil. A total of 520 children aged 1–12 years were studied through a questionnaire concerning housing, socio-economic conditions and a 24-h food intake recall. Measurements of weight and height were also performed, and three stool samples were collected on consecutive days for parasitological analysis. Scores of the standard deviation (z-scores) for the weight-for-height and height-for-age were used to characterise the growth profile. A high prevalence of intestinal parasites was detected, with Giardia lamblia (44%), Endolimax nana (43%), Ascaris lumbricoides (41%) and Trichuris trichiura (40%) being the most prevalent. Eleven per cent of the children were classified as showing stunting. Inadequate daily caloric intake was observed in 78% of the population and the proportion of those with inadequate protein intake was 34%. Logistic regression analysis was employed for the multivariate study. Stunting was significantly associated with estimators of low economic income, inadequate protein intake and polyparasitism, especially the association between Ascaris lumbricoides and Trichuris trichiura .     

Aids in diagnosis of suspect ectopic ureters in female patients

When suspected ectopic ureters cannot be visualized by conventional methods, such as excretory urogram, nephrotomograms, or by intravenous indigo carmine, then direct injection of vaginal, suburethral, or paraurethral "swellings," which are in effect dilated terminal ureters, may confirm the diagnosis.     

Induction of differentiation in human rhabdomyosarcomas

The effectiveness of all presently employed cancer therapies is limited by tumour cell heterogeneity. In patients with rhabdomyosarcomas (RMS), differentiation seemed to be associated with poor prognosis and vice versa. In order to confirm the validity of this observation, we have developed in vitro and in vivo models of RMS wherein the degree of tumour cell differentiation could be manipulated. On subcutaneous implantation in nude mice, 4 of 8 alveolar rhabdomyosarcomas (A-RMS), produced tumours. In 3 of these 4 tumours the N- myc gene was amplified. In contrast, 2 embryonal (E-RMS) lacked N-myc amplification and also failed to grow in nude mice. Two cell lines from E-RMS formed tumours in nude mice. In vitro, a reduction in bovine serum concentration or supplementation of the medium with horse serum induced marked differentiation in an A-RMS but not in an E-RMS. In vivo, subcutaneous xenografts of undifferentiated A-RMS could be induced to differentiate by intratumoural injection of horse serum or transplantation into the peritoneal cavity of rats. This dramatic degree of differentiation was detected by histology and immunocytochemical staining using 3 different markers, viz, desmin, vimentin and myoglobin. Somewhat remarkably, when these differentiated A-RMS growing in the peritoneal cavities of rats, were reinplanted into peritoneal cavities of other rats they failed to grow. On the other hand, if they were reimplanted subcutaneously in other rats they grew well and reverted to an undifferentiated morphology. In contrast, the E-RMS could not be induced to undergo differentiation by horse serum and also failed to grow in the peritoneal cavity of rats.     

From occupational medicine to workers' health]

The evolution of the concepts and practice of occupational medicine, occupational health and workers' health is tentatively reviewed. An attempt is made to answer the following questions: what were the major characteristics of occupational medicine throughout its evolution? How and why did occupational medicine evolve into occupational health? Why has the "occupational health model" become inadequate? Within what context did workers' health arise? What are the principal characteristics of workers' health?     

Validity and reliability of three generic outcome measures for hand disorders

This is an assessment of three different outcome measures for the hand: the Hand Clinic Questionnaire (HCQ); the Patient Evaluation Measure (PEM); and the Hand Outcome Survey Sheet (HOSS). Each measure has been tested for its reliability and validity. The results suggest that the PEM and the HCQ are comparably consistent but the PEM is more reproducible. Both the PEM and HOSS are valid questionnaires. The PEM is suitable for use in an outpatient clinic and as a postal questionnaire. The HOSS may be used for research or audit especially when the injury has been measured using the Hand Injury Severity Score.     

Neuropsychiatric evaluation in subjects chronically exposed to organophosphate pesticides.

Long-term exposure to low levels of organophosphate pesticides (OP) may produce neuropsychiatric symptoms. We performed clinical, neuropsychiatric, and laboratory evaluations of 37 workers involved in family agriculture of tobacco from southern Brazil who had been exposed to OP for 3 months, and in 25 of these workers, after 3 months without exposure to OP. Plasma acetylcholinesterase activity levels of all subjects were within the normal range (3.2 to 9.0 U/l) and were not different between on- and off-exposure periods (4.7 +/- 0.9 and 4.5 +/- 1.1 U/l, respectively). Clinically significant extrapyramidal symptoms were present in 12 of 25 subjects, which is unexpected in such a population. There was a significant reduction of extrapyramidal symptoms after 3 months without exposure to OP, but 10 subjects still had significant parkinsonism. Mini-mental and word span scores were within the expected range for this population and were not influenced by exposure to OP. Eighteen of the 37 subjects (48%) had current psychiatric diagnoses in the first interview (13 with generalized anxiety disorder and 8 with major depression). Among the 25 subjects who completed both evaluations, the total number of current psychiatric diagnoses, after 3 months without using OP, dropped from 24 to 13 and the number of affected individuals with any psychiatric diagnosis dropped from 11 to 7. In conclusion, this study reinforces the need for parameters other than acetylcholinesterase activity to monitor for chronic consequences of chronic low-dose OP exposure, and it suggests that subjects have not only transient motor and psychiatric consequences while exposed, but may also develop enduring extrapyramidal symptoms.