Antiamnestic Effects of Antibodies to Glutamate in Experimental Alzheimer’s Disease

Experiments on rats showed that neurodegenerative brain damage caused by administration of neurotoxic fragment of β-amyloid protein Aβ_25-35 in a dose of 2 μg into Meynert giant cell nucleus leads to long-term memory impairment in rats. Intranasal administration of antibodies to glutamate in a dose of 300 μg/kg 1 h after damage restores learning capacity of the experimental animals in the conditioned passive avoidance paradigm.     

Effect of Antibodies to Glutamate on Retention of Conditioned Passive Avoidance Response in Rats with Ischemic Injury of the Prefrontal Cortex

Experiments were performed on rats with bilateral photothrombosis of vessels in the prefrontal cortex. Intranasal administration of antibodies to glutamate (1 h after ischemia of the brain cortex) improved retention of conditioned passive avoidance response, which was elicited before ischemic damage. The content of antibodies to glutamate in the serum of rats increased significantly on day 8 after bilateral photochemical thrombosis of vessels in the prefrontal cortex compared to that in the control.     

Language Abilities of Russian Primary-School-Aged Children with Autism Spectrum Disorder: Evidence from Comprehensive Assessment

Journal of Autism and Developmental Disorders - The purpose of the present research was to comprehensively assess the language abilities of Russian primary-school-aged children with Autism Spectrum...     

Chlamydia Pneumoniae and Immunoinflammatory Reactions in an Unstable Atherosclerotic Plaque in Humans

Bulletin of Experimental Biology and Medicine - Comparative study of the walls of the aorta, coronary artery, and a. basilaris detected for the first time intra- and extracellular depositions of...     

Rosette formation by human,guinea pig,and rat lymphocytes with spermatozoa

Cells forming rosettes with homologous or heterologous spermatozoa were found in the thymus, spleen, and bone marrow of sexually mature guinea pigs and of 14–30-week-old human fetuses, and also in the peripheral blood of men suffering from sterility. On the development of autoimmune orchitis after measured trauma to the testis in rats or after immunization of guinea pigs with testicular tissue homogenate mixed with Freund's complete adjuvant, cells forming rosettes with spermatozoa were found to appear in the spleen and thymus of the rats, and their number in the lymphoid organs of the guinea pigs increased. These procedures had no effect on the number of cells forming rosettes with sheep red blood cells in the lymphoid organs of rats and guinea pigs. The possible use of this newly discovered ability of human and animal lymphocytes to form spontaneous and immune rosettes with spermatozoa as a means of assessing the degree of differentiation of lymphocytes and of their sensitization to spermatozoal antigens in cases of disturbance of spermatogenesis of autoimmune nature is discussed.Laboratory of Human Embryonic Histogenesis, Institute of Human Morphology, Academy of Medical Sciences of the USSR, Moscow. (Presented by Academician of the Academy of Medical Sciences of the USSR A. P. Avtsyn.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 83, No. 4, pp. 464–467, April 1977.     

Phagocytic Activity and State of Bactericidal Systems in Polymorphonuclear Leukocytes from Patients with Alzheimer's Disease

Phagocytic activity of peripheral blood neutrophils underwent phase changes in patients with Alzheimer's disease. Neutrophils retained the ability to engulf microbes, but their digestive activity decreased at the early stage of Alzheimer's disease. At the late stage we observed a decrease in the count of phagocytizing neutrophils, reduction of myeloperoxidase activity, and increase in the content of cationic proteins.     

Autoimmune nature of the disturbance of spermatogenesis in rats with experimental varicocele

Measured disturbance of the venous outflow from the left testis in rats causes the development of destructive changes in the spermatogenic epithelium both in the testis on the side of the operation and also in the contralateral organ. Disturbances of spermatogenesis in rat testes (foci of desquamation of spermatogenic epithelium, disorganization and degeneration of the sex cells, emptying of the seminiferous tubules) are similar to those in men with varicocele, so that the results of such experiments can be regarded as an experimental model of varicocele. In the experimental rats the permeability and fine structure of the blood-testis barrier were disturbed in both testes, the pattern of the morphological changes was similar with that observed during the development of autoimmune orchitis, and lymphocytes sensitized to spermatozoal antigens were found in the lymphoid organs. Taken as a whole, the results suggest involvement of immunologic mechanisms in the development of the pathological changes in the testes in varicocele.Laboratory of Human Embryonic Histogenesis, Institute of Human Morphology, Academy of Medical Sciences of the USSR. Department of Pediatric Surgery, N. I. Pirogov Second Moscow Medical Institute. (Presented by Academician of the Academy of Medical Sciences of the USSR A. P. Avtsyn.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 87, No. 1, pp. 44–48, January, 1979.     

Count and phagocytic activity of leukocytes in rats with experimental depressive syndrome caused by systemic administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine

Leukocyte count decreased, relative content of neutrophils and monocytes increased, and their phagocytic activity was suppressed in rats with 1-methyl-4-phenyl-1,2,3,4-tetrahydropyridine-induced depressive syndrome at the stage of acute behavioral depression. The severity of behavioral depression inversely correlated with changes in the absolute neutrophil and monocyte counts.