Emphysematous cystitis presenting with subcutaneous emphysema

A case is reported of subcutaneous emphysema of the neck in association with emphysematous cystitis and uncontrolled diabetes. Problems in its management are discussed. Anatomic pathway for the spread of the gas from the bladder to the subcutaneous tissues of the neck and the back is speculated.     

Nature of estrogenic and anti-estrogenic actions of centchroman on rat uterus.

The uterine effects of centchroman, 3,4-trans-2,2-dimethyl-3-phenyl- 4-(p(beta-pyrrolidioethoxy)-phenyl)-7-methoxy chroman hydrochloride in ovariectomized rats, with or without estrogen treatment, were studied. Centchroman had a very weak estrogenic action in the absence of exogenous estrogen. However, it did have a relatively strong antiestrogenic action when estradiol benzoate was administered. The results indicate a competitive inhibition of estrogen action at the receptor site. It is suggested that the action of centchroman is similar to that of clomiphene.