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11.
Marzieh Fathi Seyyed Abbas Hasani Mohammad Amin Zare Marzieh Daadpey Nader Hojati Firoozabadi Daniyal Lotfi 《Journal of Ultrasound》2015,18(1):57-62
Purpose
Accurate early diagnosis of appendicitis can decrease its complications and minimize the mortality, morbidity and costs. This prospective study evaluates the accuracy of bedside emergency physician performed ultrasound study diagnosis in acute appendicitis.Methods
Patients who were suspicious to have appendicitis based on their clinical findings were included and underwent emergency physician performed ultrasound study. Then they were followed up until the recognition of final diagnosis based on pathology report or identification of an alternative diagnosis. Ultrasound studies were done by post-graduate year three emergency medicine residents or emergency medicine attending physicians who were attended in a 4 h didactic and practical course and with 7.5 MHz linear probe both in longitudinal and axial axes.Results
Ninety-seven patients were included and analyzed. 27 (27.8 %) of patients had appendicitis according to the results of emergency physicians performed ultrasound studies. 19 (70.37 %) of them had appendicitis according to their pathologic reports too. Forty-three (44.3 %) of patients had appendicitis according to pathology reports. Only 19 (44.18 %) of them were diagnosed by emergency physicians. Emergency physician performed ultrasound study had a sensitivity of 44.18 %, specificity of 85.18 %, positive predictive value of 70.37 %, negative predictive value of 65.71 % and overall accuracy of 67.01 % in diagnosing appendicitis in patients clinically suspicious to have acute appendicitis.Conclusion
Emergency physician performed bedside ultrasound has an acceptable overall accuracy but its sensitivity is low thus it can help emergency physicians to diagnose the acute appendicitis when used in conjunction with other clinical and para-clinical evaluations but not per se. 相似文献12.
Antiviral potential of medicinal plants against HIV,HSV, influenza,hepatitis, and coxsackievirus: A systematic review 下载免费PDF全文
Muhammad Akram Imtiaz Mahmood Tahir Syed Muhammad Ali Shah Zahed Mahmood Awais Altaf Khalil Ahmad Naveed Munir Muhammad Daniyal Suhaila Nasir Huma Mehboob 《Phytotherapy research : PTR》2018,32(5):811-822
Viral infections are being managed therapeutically through available antiviral regimens with unsatisfactory clinical outcomes. The refractory viral infections resistant to available antiviral drugs are alarming threats and a serious health concern. For viral hepatitis, the interferon and vaccine therapies solely are not ultimate solutions due to recurrence of hepatitis C virus. Owing to the growing incidences of viral infections and especially of resistant viral strains, the available therapeutic modalities need to be improved, complemented with the discovery of novel antiviral agents to combat refractory viral infections. It is widely accepted that medicinal plant heritage is nature gifted, precious, and fueled with the valuable resources for treatment of metabolic and infectious disorders. The aims of this review are to assemble the facts and to conclude the therapeutic potential of medicinal plants in the eradication and management of various viral diseases such as influenza, human immunodeficiency virus (HIV), herpes simplex virus (HSV), hepatitis, and coxsackievirus infections, which have been proven in diverse clinical studies. The articles, published in the English language since 1982 to 2017, were included from Web of Science, Cochrane Library, AMED, CISCOM, EMBASE, MEDLINE, Scopus, and PubMed by using relevant keywords including plants possessing antiviral activity, the antiviral effects of plants, and plants used in viral disorders. The scientific literature mainly focusing on plant extracts and herbal products with therapeutic efficacies against experimental models of influenza, HIV, HSV, hepatitis, and coxsackievirus were included in the study. Pure compounds possessing antiviral activity were excluded, and plants possessing activity against viruses other than viruses in inclusion criteria were excluded. Hundreds of plant extracts with antiviral effect were recognized. However, the data from only 36 families investigated through in vitro and in vivo studies met the inclusion criteria of this review. The inferences from scientific literature review, focusing on potential therapeutic consequences of medicinal plants on experimental models of HIV, HSV, influenza, hepatitis, and coxsackievirus have ascertained the curative antiviral potential of plants. Fifty‐four medicinal plants belonging to 36 different families having antiviral potential were documented. Out of 54 plants, 27 individually belong to particular plant families. On the basis of the work of several independent research groups, the therapeutic potential of medicinal plants against listed common viral diseases in the region has been proclaimed. In this context, the herbal formulations as alternative medicine may contribute to the eradication of complicated viral infection significantly. The current review consolidates the data of the various medicinal plants, those are Sambucus nigra, Caesalpinia pulcherrima, and Hypericum connatum, holding promising specific antiviral activities scientifically proven through studies on experimental animal models. Consequently, the original research addressing the development of novel nutraceuticals based on listed medicinal plants is highly recommended for the management of viral disorders. 相似文献
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14.
Selvakumar Govindhasamy Pushpavathi Ahmed Mohammad Ejaz Raikwar Sudhanshu P. Thangavel Ramasamy Kempuraj Duraisamy Dubova Iuliia Saeed Daniyal Zahoor Haris Premkumar Keerthivaas Zaheer Smita Iyer Shankar Zaheer Asgar 《Journal of neuroimmune pharmacology》2019,14(4):537-550
Journal of Neuroimmune Pharmacology - Microglial cells are brain specific professional phagocytic immune cells that play a crucial role in the inflammation- mediated neurodegeneration especially in... 相似文献
15.
Raikwar Sudhanshu P. Kikkeri Nidhi S. Sakuru Ragha Saeed Daniyal Zahoor Haris Premkumar Keerthivaas Mentor Shireen Thangavel Ramasamy Dubova Iuliia Ahmed Mohammad Ejaz Selvakumar Govindhasamy P. Kempuraj Duraisamy Zaheer Smita Iyer Shankar S. Zaheer Asgar 《Journal of neuroimmune pharmacology》2019,14(4):608-641
Journal of Neuroimmune Pharmacology - Despite significant advancements in the field of molecular neurobiology especially neuroinflammation and neurodegeneration, the highly complex molecular... 相似文献
16.
Feng Xiao Jialong Fan Chunyi Tong Chang Xiao Zhou Wang Bin Liu Muhammad Daniyal Wei Wang 《RSC advances》2019,9(48):27911
The tumor variability and low efficiency associated with conventional chemical drugs provide an impetus to develop drug-carrying systems with targeted accumulation and controllable release behavior. Herein, DOX-loaded Prussian blue (PB) nano-composites are developed after coating with erythrocyte membrane (EM) and modifying with folic acid (FA). In these nano-composites, PB nanoparticles mixture with different shapes were adopted to improve the photothermal performance, which is highly helpful for cancer photothermal ablation and controllable drug release. In addition, the nano-composites were endowed with high biocompatibility, immune evading capacity, pH-/photo-responsive release behavior, and markedly prolonged blood circulation time, which was reflected by a 99.6% cervical tumor growth inhibition value (TGI) in vivo. Meanwhile, they functioned as multimodal bioimaging agents for photothermal, fluorescence, and photoacoustic imaging of tumors. The reported strategy can be applied for personalized therapy of various tumors by modifying the tumor-targeting molecule on the surface of nanoparticles.The tumor variability and low efficiency associated with conventional chemical drugs provide an impetus to develop drug-carrying systems with targeted accumulation and controllable release behavior. 相似文献
17.
Ghazala Shaheen Muhammad Akram Farhat Jabeen Syed Muhammad Ali Shah Naveed Munir Muhammad Daniyal Muhammad Riaz Imtiaz Mahmood Tahir Aymen Owais Ghauri Sabira Sultana Rida Zainab Muslim Khan 《Clinical and experimental pharmacology & physiology》2019,46(7):613-624
Urinary tract infection (UTI) is one of the most severe public health problem affecting both sexes but females are more susceptible due to the differences in urogenital and reproductive anatomy, physiology and lifestyle. As in UTI, different parts of the urinary tract are affected and morbidity due to UTI is more common in women of all ages and older men. Due to multi‐drug resistant strains and high recurrence rate, UTI has become a major socioeconomic burden. The current review article was aimed to describe the natural therapeutic strategies to manage and cure the UTI. For this purpose, different databases including Google Scholar, Cochrane database, and PubMed etc. were explored. Inclusion criteria were any research article investigating the current therapy of UTI. It was found that microbial infections including Escherichia coli, Enterococcus faecalis and Klebsiella species are the major causes of UTI with different signs and symptoms including painful urination or dysuria, hematuria, urinary urgency, burning micturition, frequent urination, nausea, and vomiting. Antibiotics like trimethoprim, sulfamethoxazole, quinolone etc. as the first choice of the drug are used worldwide. However, due to microbial resistance, several life‐threatening side effects, repeated high doses, high cost and low efficacy of these antibiotics motivated the researchers to explore natural remedies for the treatment of UTI. Herbal medicines are effective to combat bacterial resistance with high efficacy, and easy availability with minimal or no side effects. For these reasons it has attained the attention of researchers wanting to explore the herbal treatment of UTI. Vaccinium macrocarpon, Tribulus terrestris, Trachyspermum copticum, Cinnamomum verum and Hybanthusenn easpermus are some common medicinal plants reported to have therapeutic potential for the management and cure of the UTI. Although herbal medicines have more potential over conventional medicine but more discoveries are required to explore the phytoconstituents and their mechanism of action responsible for the management and cure of UTI. 相似文献
18.
Mishra Ajay Kumar Sahu Kamal Kant Siddiqui Ahmad Daniyal George Susan V. 《Journal of thrombosis and thrombolysis》2020,49(2):332-333
Journal of Thrombosis and Thrombolysis - 相似文献
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Shadi Yaghi MD Tushar Trivedi MD MPH Nils Henninger MD PhD Dr Med James Giles MD Angela Liu MD Muhammad Nagy MD Ashutosh Kaushal MD Idrees Azher MD Brian Mac Grory MD Hiba Fakhri BS Kiersten Brown Espaillat RN Syed Daniyal Asad MD Hemanth Pasupuleti MD Heather Martin BS Jose Tan MD Manivannan Veerasamy MD Ava L. Liberman MD Charles Esenwa MD Natalie Cheng MD Khadean Moncrieffe BS Iman Moeini-Naghani MD Mithilesh Siddu MD Erica Scher MPH Christopher R. Leon Guerrero MD Muhib Khan MD Amre Nouh MD Eva Mistry MD Salah Keyrouz MD Karen Furie MD 《Annals of neurology》2020,88(4):807-816
20.
This article is based on the findings of the Hospital Support Workers Study, which includes in-depth interviews with 70 hospital housekeepers and dietary aids in Vancouver, British Columbia, Canada. As a result of provincial government legislation in 2003, all hospital-based support work in the Vancouver region was privatized and contracted out to three multinational corporations. The outsourcing of hospital support services is part of a larger global trend toward neoliberal policy reform in health care. This article presents the perceptions of hospital support workers about the consequences of contracting out on their work conditions, training, turnover rates and other issues that directly affect their quality of work and have important implications for patient health and well-being. The findings suggest serious negative consequences for the health care system as a result of the privatization and contracting out of hospital support services. 相似文献