全文获取类型
收费全文 | 18316篇 |
免费 | 1089篇 |
国内免费 | 83篇 |
专业分类
耳鼻咽喉 | 134篇 |
儿科学 | 470篇 |
妇产科学 | 452篇 |
基础医学 | 2827篇 |
口腔科学 | 704篇 |
临床医学 | 1488篇 |
内科学 | 4111篇 |
皮肤病学 | 357篇 |
神经病学 | 2166篇 |
特种医学 | 479篇 |
外科学 | 1714篇 |
综合类 | 47篇 |
一般理论 | 5篇 |
预防医学 | 1107篇 |
眼科学 | 279篇 |
药学 | 1442篇 |
中国医学 | 60篇 |
肿瘤学 | 1646篇 |
出版年
2024年 | 18篇 |
2023年 | 179篇 |
2022年 | 417篇 |
2021年 | 625篇 |
2020年 | 381篇 |
2019年 | 515篇 |
2018年 | 609篇 |
2017年 | 481篇 |
2016年 | 557篇 |
2015年 | 689篇 |
2014年 | 796篇 |
2013年 | 1027篇 |
2012年 | 1555篇 |
2011年 | 1657篇 |
2010年 | 841篇 |
2009年 | 792篇 |
2008年 | 1254篇 |
2007年 | 1183篇 |
2006年 | 1097篇 |
2005年 | 1021篇 |
2004年 | 927篇 |
2003年 | 844篇 |
2002年 | 716篇 |
2001年 | 140篇 |
2000年 | 120篇 |
1999年 | 112篇 |
1998年 | 124篇 |
1997年 | 111篇 |
1996年 | 80篇 |
1995年 | 66篇 |
1994年 | 54篇 |
1993年 | 36篇 |
1992年 | 62篇 |
1991年 | 38篇 |
1990年 | 38篇 |
1989年 | 40篇 |
1988年 | 26篇 |
1987年 | 37篇 |
1986年 | 28篇 |
1985年 | 26篇 |
1984年 | 22篇 |
1983年 | 19篇 |
1982年 | 18篇 |
1981年 | 16篇 |
1980年 | 10篇 |
1979年 | 12篇 |
1978年 | 8篇 |
1975年 | 9篇 |
1973年 | 10篇 |
1972年 | 10篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
41.
Daniela Concolino Simona Sestito Francesca Falvo Giusy Romano Miriam Ceravolo Elisa Anastasio Licia Pensabene Elisa A. Colombo Lidia Larizza 《European journal of medical genetics》2019,62(1):73-76
Clericuzio-type poikiloderma with neutropenia is a well-defined nosological entity, but despite a remarkable number of clinical reports, no long term follow-up data has been presented to date regarding patients with this rare condition.Here we describe the results of clinical follow-up of three siblings, one male (Patient 1) and two females (Patients 2 and 3), subsequent to their first clinical and then molecular diagnosis of Clericuzio-type poikiloderma with neutropenia syndrome due to mutation of USB1gene. Patient 1 always expressed the most severe phenotype, while patients 2 and 3 showed an intermediate and mild phenotype, respectively, as observed since their first clinical evaluation. None of the patients developed skin cancer and/or myelodysplastic disorders considering the peripheral haematological findings. Lens opacity, never reported before, was found in two of the three patients.The long term follow-up observations confirm the stability over time of the pronounced intra-familial heterogeneity of clinical manifestations observed prior to and upon molecular diagnosis. We conclude that prolonged follow-up is an adjunct tool to monitor intra-familial variability of PN clinical spectrum which may favour surveillance of more serious complications of the disease among siblings, when a patient-specific clinical expressivity is present. 相似文献
42.
Libra M Capello D Gloghini A Laura P Berra E Cerri M Gasparotto D Franca S De Re V Gaidano G Carbone A 《The Journal of pathology》2005,206(1):87-91
Hepatitis C virus (HCV) and aberrant somatic hypermutation (SHM) have each been suggested to contribute to the development of B-cell non-Hodgkin's lymphoma (NHL). The incidence of PIM-1, PAX-5, RhoH/TTF, and c-MYC mutations in tumour biopsy specimens from 32 HCV-infected B-cell NHL patients was analysed to determine whether the extent of aberrant SHM among these patients differed from that previously reported for HCV-negative B-cell NHL patients. Mutation of PIM-1, PAX-5, RhoH/TTF, and c-MYC was detected in 4 (13%), 5 (16%), 4 (13%), and 4 (13%) of 32 samples, respectively. In HCV-positive B-cell NHL patients, the frequency of aberrant SHM was lower than that already found in HCV-negative B-cell NHL patients. This indicates that, unlike B-cell lymphomas from HCV-negative patients, aberrant SHM may not contribute significantly to malignant transformation in HCV-associated B-cell lymphomas. 相似文献
43.
Vasculogenic mimicry has no prognostic significance in pT3 and pT4 cutaneous melanoma 总被引:4,自引:0,他引:4
Massi D Franchi A Paglierani M Ketabchi S Borgognoni L Reali UM Santucci M 《Human pathology》2004,35(4):496-502
The concept of vasculogenic mimicry has been introduced to define periodic acid-Schiff (PAS)-positive channels and loops lined by tumor cells, instead of endothelium, able to contribute to microcirculation in uveal melanomas. Previous studies have shown that the PAS-positive patterns are associated with a poor prognosis in uveal melanoma. The aim of the current study was to investigate whether vasculogenic mimicry has a prognostic impact in pT3 and pT4 cutaneous melanoma. Fifteen patients with pT3 and pT4 cutaneous melanoma who did not experience progression after 10 years of follow-up and 30 matched controls who underwent progression were selected. Tumor sections were stained with PAS reaction, omitting the nuclear counterstaining. For immunohistochemistry, sections were stained with CD31, CD105 (endoglin), and laminin. Differences in the distribution of the PAS-positive patterns and a series of clinicopathological variables were evaluated by the Pearson chi(2) and Mann-Whitney U tests. We observed PAS-positive linear sheets, arcs, elliptical loops, and networks encircling roundish to oval aggregates of melanoma cells. The overall distribution of the PAS-positive patterns did not match with the blood microvessels' architecture as detected by immunohistochemical analysis. No statistically significant differences in the distribution of PAS-positive patterns were found between cases and controls. The presence of a parallel pattern correlated significantly with thickness (P = 0.04), whereas an inverse correlation was found with vessel area (P = 0.05). In conclusion, our results suggest that there is a mismatch between vasculogenic mimicry and tumor angiogenesis and do not support any prognostic role of vasculogenic mimicry in thick cutaneous melanoma. 相似文献
44.
45.
Alessandro Daniotti Gaetano Povolo Agata Barchitta Aierken Abudureheman Paolo Cardaioli Cristina Basso 《Cardiovascular pathology》2004,13(6):330-333
A 51-year-old woman suffered rapidly irreversible cardiogenic shock with left hemiparesis. Transesophageal echocardiography, which represents an essential imaging tool in the emergency room, ruled out aortic dissection involving branch vessels but did not allow an in vivo diagnosis of spontaneous coronary dissection. The in vivo diagnosis of spontaneous coronary dissection is rather difficult because of the dramatic clinical presentation and selective coronary angiography requirement. 相似文献
46.
47.
Lorenzo Moretta Maria Cristina Mingari Daniela Pende Cristina Bottino Roberto Biassoni Alessandro Moretta 《Journal of clinical immunology》1996,16(5):243-253
Natural Killer cells are likely to play an important role in the host defenses because they kill virally infected or tumor cells but spare normal self-cells. The molecular mechanism that explains why NK cells do not kill indiscriminately has recently been elucidated. It is due to several specialized receptors that recognize major histocompatibility complex (MHC) class I molecules expressed on normal cells. The lack of expression of one or more HLA class I alleles leads to NK-mediated target cell lysis. Different types of receptors specific for groups of HLA-C, HLA-B, and, very recently, HLA-A alleles have been identified. While in most instances, they function as inhibitory receptors, an activatory form of the HLA-C-specific receptors has been identified in some donors. Molecular cloning of HLA-C-, HLA-B- or HLA-A-specific receptors has revealed new members of the immunoglobulin superfamily with two or three Ig-like domains, respectively, in their extracellular portion. While the inhibitory form is characterized by a long cytoplasmic tail associated with a non-polar transmembrane portion, the activatory one has a short tail asociated with a Lys-containing transmembrane portion. Thus, these human NK receptors are different from the murine Ly49, that is a type II transmembrane protein characterized by a C-type lectin domain. A subset of activated T lymphocytes expresses NK-type class I-specific receptors. These receptors exert an inhibiting activity on T cell receptor-mediated functions and may provide an important mechanism of downregulation of T cell responses. 相似文献
48.
Requirement for tumor necrosis factor receptor 2 expression on vascular cells to induce experimental cerebral malaria 下载免费PDF全文
Stoelcker B Hehlgans T Weigl K Bluethmann H Grau GE Männel DN 《Infection and immunity》2002,70(10):5857-5859
Using tumor necrosis factor receptor type 2 (TNFR2)-deficient mice and generating bone marrow chimeras which express TNFR2 on either hematopoietic or nonhematopoietic cells, we demonstrated the requirement for TNFR2 expression on tissue cells to induce lethal cerebral malaria. Thus, TNFR2 on the brain vasculature mediates tumor necrosis factor-induced neurovascular lesions in experimental cerebral malaria. 相似文献
49.
50.
d'Amati G Bagattin A Bauce B Rampazzo A Autore C Basso C King K Romeo MD Gallo P Thiene G Danieli GA Nava A 《Human pathology》2005,36(7):761-767
We report on a family with a history of sudden death and effort-induced polymorphic ventricular arrhythmias. The index case was a 17-year-old boy who died suddenly and at postmortem had evidence of fibrofatty replacement in the right ventricular free wall, consistent with arrhythmogenic right ventricular cardiomyopathy, as well as calcium phosphate deposits within the myocytes. A molecular genetics investigation carried out in the paraffin-embedded myocardium of the subject and in blood samples of family members disclosed a missense mutation in exon 3 (230C-->T; A77V) of the cardiac ryanodine receptor type 2 gene. The carriers showed effort-induced polymorphic ventricular tachycardia in the setting of normal resting electrocardiogram and trivial echocardiographic abnormalities, consistent with catecholaminergic polymorphic ventricular tachycardia. The observation of both arrhythmogenic right ventricular cardiomyopathy type 2 and catecholaminergic polymorphic ventricular tachycardia in the same family suggests that the two entities might correspond to different degrees of phenotypic expression of the same disease. This experience underscores the importance of a precise autopsy diagnosis in the case of sudden cardiac death, including molecular genetics, and the mission of pathologists to guide further clinical investigation of family members. 相似文献