三叉神经鞘瘤的外科治疗

目的 探讨三叉神经鞘瘤最佳外科手术入路。方法 回顾性分析７５例三叉神经鞘瘤的临床资料和随访结果。按时间先后分为早期组和后期组进行对比。结果 早期组（１９７８￣１９８４年）应用常规硬脑膜内入路：后期组（１９８５￣１９９５年）除颅后窝型应用枕下硬膜内入路外,均用颅底开颅硬脑膜外入路。早期和后期组肿瘤全切率分别为５８％（２０／３５）和８０％（３２／４０）（Ｐ〈０．０５）,暂时和永久颅神经障碍分别为６３％     

凉山彝族男性血管紧张素转换酶基因多态性与高血压的关系

目的　探讨血管紧张素转换酶（ＡＣＥ） 基因多态性与高血压的关系。方法　应用横断面调查方法和ＰＣＲ 技术。结果　正常血压人群ＡＣＥ 基因ＤＤ、ＩＤ 和ＩＩ基因型分别占１３ ．０ ％ 、５０ ．９ ％ 和３６ ．１ ％ 。Ｉ和Ｄ等位基因频率分别是为６１ ．６ ％ 和３８ ．４ ％ 。高血压人群ＡＣＥ 基因ＤＤ、ＩＤ 和ＩＩ基因型分别占９ ．７ ％ 、４８ ．４ ％ 和４１ ．９ ％ 。Ｉ和Ｄ 等位基因频率分别是６６ ．１ ％ 和３３ ．９ ％ 。彝族男性高血压和正常血压人群的ＡＣＥ基因型分布及Ｉ／Ｄ 等位基因频率差异无显著性。结论　彝族男性ＡＣＥ 基因多态性与高血压的关联尚不能确定。     

Social support, social selection and self-assessed health status: results from the veterans health study in the United States

This study provided a comprehensive assessment of the association between social support and health using longitudinal data from the Veterans Health Study. Unlike previous studies which examined the relationship between one single domain of social support with either mental or physical health, the present study assessed the effects of three different domains of social support on multiple measures of health. The findings of the study indicated that social support tended to mediate the deleterious effects of non-military traumatic events; whereas the adverse consequences of traumatic events experienced in the military were not affected by social support, suggesting that stressors associated with combat had a long lasting effect on the health status of veterans. The study results revealed that compared with those with better health, respondents with poor health were more likely to have lower levels of social support, suggesting that poor health might be a barrier to a person's ability to participate and/or maintain social relationships. The study also showed that different types of social support had varying beneficial effects on different measures of health. While perceived support had a strong effect on all the measures of health (except alcoholism) included in the study, living arrangement had a significant effect on post-traumatic stress disorder or physical health and participation in group activities had a strong effect only on physical functioning. The results of the study highlight the need for future research to determine whether particular types of social support affect various aspects of health differently. This simultaneous focus on multiple support functions and health outcomes is important because it provides insight into the mechanisms linking social support to health.     

杜仲康茶对性功能的影响及其急性毒性实验研究

目的探讨杜仲康茶对大鼠性功能的影响及其对小鼠的急性毒性作用。方法采用壮阳试验和交配实验方法。结果杜仲康茶０．２、０．６和２ｇ／ｋｇ灌胃有使阴茎勃起潜伏期缩短的趋势,但是与对照组相比无显著性差异。杜仲康茶２ｇ／ｋｇ组明显增多雄性大鼠交配实验中的扑捉次数和射精次数,明显缩短射精潜伏期。杜仲康茶以最大浓度最大剂量给小鼠灌胃后观察７ｄ,全部动物存活,未观察到急性毒性的发生。结论杜仲康茶具有增强雄性大鼠性功能的作用,且无毒性作用     

无先兆型偏头痛患者颅外血管经颅多普勒的检测分析

目的探讨经颅多普勒（TCD）对无先兆型偏头痛患者头痛间歇期顿外血管的血液动力学变化。方法应用经颅多普勒（TCD）对96例无先兆型偏头痛患者的576根颅外血管进行TCD检测,并与29名正常人进行对照。结果在受检的576根颅外血管中,有283根血管峰血流速度异常升高,异常率为49．13％。颅外血管的异常高速血流主要表现为颈总动脉和颈外动脉,较正常人显著升高（P均＜0.01）。结论在偏头痛病人TCD检测中,不仅要考虑颅内血管的血流变化,更要注意观察顿外血管的血液动力学的改变。     

铁路参与国际集装箱多式联运的问题及其对策

分析了我国铁路参与国际集装箱多式联运存在的问题,包括管理体制的不适应、运行机制的不适应、集装箱运价政策的不适应、集装箱运输设施的不适应等,并提出了相应的对策与措施,包括:改进铁路集装箱运输管理体制和经营体制;加强专业机构建设和人才培训,提高服务水平;对集装箱多式联运给予政策优惠;增加投资,完善配套设施;采用先进的科学技术,推进铁路集装箱运输规范化、现代化等.     

四甲基偶氮唑盐法用于非小细胞肺癌药敏试验条件的筛选

目的筛选非小细胞肺癌药敏试验的条件。方法取25例非小细胞肺癌患者的瘤细胞,用四甲基偶氮唑盐（MTT）法观察9种化疗药物,在不同浓度、不同时间对瘤细胞的敏感性。结果9种化疗药物对瘤细胞的敏感性,有随着药物浓度的增加、作用时间的延长而增高的趋势,但每个药物都有各自的特点。结论非小细胞肺癌细胞MTT法药敏试验的浓度应为临床用药量的计算值,药物作用时间应以48h为宜。     

围手术期心脏起搏临床应用探讨

报道５８例非心脏手术的围手术期心脏起搏临床应用,重点讨论围手术期心脏起搏的方法与适应症。认为经静脉右室起搏疗效恒定可靠,适应症范围广。对伴有缓慢型或快速型心律失常的心脏病或潜在心脏病患者,围手术期心脏起搏适应症可适当放宽,以确保麻醉手术顺利进行     

高度近视眼白内障手术疗效观察

目的　分析高度近视眼白内障手术效果。方法　高度近视合并白内障病例共１９１ 例（２７９ 只眼）,行白内障术后３ｍｏ以上,随访视力、眼屈光度及并发症,计算测量误差及ＳＲＫ－ＩＩ公式误差。结果　术后矫正视力０ ．５ 者２００ 只眼,占７１．７ ％ ;矫正视力＜ ０．１ 者１３ 只眼,占４ ．７ ％ － 眼轴越长,近视性眼底病变越重。术后发生视网膜脱离２ 只眼（０ ．７％） 。眼轴长度测量误差值平均为０．５３ｍｍ ,ＳＲＫ－ＩＩ公式计算的平均绝对屈光误差值为１．１２Ｄ。结论　高度近视眼白内障手术效果较一般人群差,且眼轴越长效果越差。     

Inhibition of herpes simplex virus type 1 and adenovirus type 5 by heterocyclic Schiff bases of aminohydroxyguanidine tosylate

Eleven heterocyclic Schiff bases of aminohydroxyguanidine tosylate (SB-AHGs), compounds I-XI, were tested for antiviral activity against herpes simplex virus type 1 (HSV-1) and adenovirus type 5 (Ad 5) via plaque reduction and virus yield reduction assays. This work was undertaken to test the hypothesis that low molecular weight SB-AHGs (MW < 235 for the free SB) make better antiviral agents than high MW SB-AHGs (MW > 300). The plaque reduction assay method demonstrated that three compounds, I, VII and IX, had moderate activity against HSV-1, with 50% inhibitory concentration (IC50) values of 38.0, 23.5 and 52.1 microM, respectively. Against Ad 5, compounds I, VIII and XI exhibited moderate activity, with IC50 values of 52.7, 19.3 and 5.1 microM, respectively. Among the compounds screened, compound I (1-[(3'-hydroxy-6'-methyl-2'-pyridyl)methylene]amino-3-hydroxyguanidi ne tosylate) was the most promising antiviral candidate, with selectivity indices (SI) of 10.2 (HSV-1) and 7.6 (Ad 5), respectively. Virus yield reduction assays indicated that compound I had less antiviral potency against HSV-1 than against Ad 5. The antiviral effects of compound I at a high input virus multiplicity of infection (MOI > 5) indicated that compound I had effective anti-adenoviral activity at 24 h post infection. This work demonstrated that some of SB-AHGs only have moderate antiviral activities against Ad 5 and HSV-1 viruses. In general, low MW SB-AHGs have low cytotoxicities to the host cells.