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排序方式: 共有300条查询结果,搜索用时 31 毫秒
101.
Okamoto Y Minakata K Yunoki T Katsu M Chino S Matsumoto M 《General thoracic and cardiovascular surgery》2011,59(11):730-736
Purpose
There is no clear consensus on how to treat patients undergoing coronary artery bypass grafting (CABG) who have severe concomitant carotidcerebral artery stenosis. The aim of this study was to evaluate our surgical results in patients with severe carotid and/or cerebrovascular disease undergoing CABG. 相似文献102.
Kasami M Uematsu T Honda M Yabuzaki T Sanuki J Uchida Y Sugimura H 《Breast (Edinburgh, Scotland)》2008,17(5):523-527
Neoadjuvant chemotherapy (NAC) is now a relatively standard treatment for breast carcinoma. However, some tumors are known to develop resistance to chemotherapies. We investigated whether the status of estrogen receptor (ER), progesterone receptor (PR) and Her-2 expressions in breast cancer cases prior to NAC could be changed after NAC. We used immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH) methods. No differences were found in ER or Her-2 status, but a significant difference was found in PR status. Changes in Her-2 status were suspected in four specimens after NAC (3+ to 1+ for 3 patients, and 1+ to 3+ for one patient) according to the IHC results. However, in all four of these cases, FISH of the resections showed no change. When IHC indicates a change in Her-2 expression after NAC, FISH is recommended. 相似文献
103.
Shihoko Miyazaki Taro Funamoto Tomohisa Sekimoto Syuji Kurogi Tomomi Ohta Takuya Nagai Takuya Tajima Mai Imasaka Kumiko Yoshinobu Kimi Araki Masatake Araki Narantsog Choijookhuu Yoshitaka Hishikawa Etsuo Chosa 《ACTA HISTOCHEMICA ET CYTOCHEMICA》2022,55(3):99
Epithelial protein lost in neoplasm (EPLIN) is an actin-associated cytoskeletal protein that plays an important role in epithelial cell adhesion. EPLIN has two isoforms: EPLINα and EPLINβ. In this study, we investigated the role of EPLINβ in osteoblasts using EPLINβ-deficient (EPLINβGT/GT) mice. The skeletal phenotype of EPLINβGT/GT mice is indistinguishable from the wildtype (WT), but bone properties and strength were significantly decreased compared with WT littermates. Histomorphological analysis revealed altered organization of bone spicules and osteoblast cell arrangement, and decreased alkaline phosphatase activity in EPLINβGT/GT mouse bones. Transmission electron microscopy revealed wider intercellular spaces between osteoblasts in EPLINβGT/GT mice, suggesting aberrant cell adhesion. In EPLINβGT/GT osteoblasts, α- and β-catenins and F-actin were observed at the cell membrane, but OB-cadherin was localized at the perinuclear region, indicating that cadherin-catenin complexes were not formed. EPLINβ knockdown in MC3T3-e1 osteoblast cells showed similar results as in calvaria cell cultures. Bone formation markers, such as RUNX2, Osterix, ALP, and Col1a1 mRNA were reduced in EPLINβ knockdown cells, suggesting an important role for EPLINβ in osteoblast formation. In conclusion, we propose that EPLINβ is involved in the assembly of cadherin-catenin complexes in osteoblasts and affects bone formation. 相似文献
104.
Wilhelm J. Schulte-Mattler Stephan Zierz Eckart Lensch Justus Faust Wilfred A. Nix Eveline Wandel Ritsuko Hanajima Mitsuru Kawai Masahiko Yamamoto Kyoko Hamada Masatake Shimokawa Takayoshi Kobayashi Mamede de Carvalho Jos Ferro M. L. Sales Luis Giuseppe Vita Maria C. Monici Antonio Toscano Corrado Messina 《Muscle & nerve》1996,19(7):926-931
105.
Takafumi Yamada Masatake Takagi Toshiyasu Kugimiya Naotaka Miyagawa Ryuichiro Shibata Hiroshi Hashiyada Hiroichiro Yamaguchi 《Heart and vessels》1995,10(6):310-317
The effects of Na+ and Ca2+ concentrations in the reperfusate on post-ischemic myocardial recovery were examined. Also, the myocardial protective effects
of amiloride, an inhibitor of the Na+/Ca2+ and Na+/H+ exchange systems, added to cardioplegic solutions were assessed, using an isolated working rat heart perfusion system. Global
myocardial ischemia was induced by 30-min normothermic cardioplegic arrest, using St. Thomas’ solution. The concentration
of Na+ in the reperfusate varied, stepwise, from 75 to 145 mM/l, and that of Ca2+, from 0.1 to 2.5 mM/l. In this study post-ischemic functional recovery was best at 110 mM/l Na+ and 1.2–1.8 mM/l Ca2+ in the reperfusate. A significantly greater postischemic functional recovery and a lower creatine kinase release were observed
when amiloride was added to the cardioplegic solution. Ca2+ overload via Na+/Ca2+ and Na+/H+ exchange systems would, thus, appear to be due, at least in part, to post-ischemic reperfusion injury. 相似文献
106.
Left atrial volume and the risk of paroxysmal atrial fibrillation in patients with hypertrophic cardiomyopathy. 总被引:2,自引:0,他引:2
Tomoko Tani Kazuaki Tanabe Miwa Ono Kazuto Yamaguchi Midori Okada Toshiaki Sumida Toshiko Konda Yoko Fujii Junichi Kawai Toshikazu Yagi Masatake Sato Motoaki Ibuki Minako Katayama Koichi Tamita Kenji Yamabe Atsushi Yamamuro Kunihiko Nagai Kenichi Shiratori Shigefumi Morioka 《Journal of the American Society of Echocardiography》2004,17(6):644-648
Paroxysmal atrial fibrillation (PAF) is a common complication of patients with hypertrophic cardiomyopathy, often leading to acute or progressive heart failure and cerebral infarction. We assessed the echocardiographic data of 141 consecutive patients with hypertrophic cardiomyopathy, with and without PAF. In all, 31 patients (22%) had a history of PAF with spontaneous conversion to in sinus rhythm. Left atrial volume and left atrial volume indexed to body surface area were significantly increased for patients with PAF compared with those without PAF. Maximum left atrial volume was the most sensitive and specific parameter for the occurrence of PAF in patients with hypertrophic cardiomyopathy. 相似文献
107.
108.
109.
Ryoko Tsukahara Shinji Yamamoto Keisuke Yoshikawa Mari Gotoh Tamotsu Tsukahara Hiroyuki Neyama Satoshi Ishii Noriyuki Akahoshi Keisuke Yanagida Hayakazu Sumida Masatake Araki Kimi Araki Ken-ichi Yamamura Kimiko Murakami-Murofushi Hiroshi Ueda 《Journal of pharmacological sciences》2018,136(2):93-96
Lysophosphatidic acid (LPA) and LPA1 receptor signaling play a crucial role in the initiation of peripheral nerve injury-induced neuropathic pain through the alternation of pain-related genes/proteins expression and demyelination. However, LPA and its signaling in the brain are still poorly understood. In the present study, we revealed that the LPA5 receptor expression in corpus callosum elevated after the initiation of demyelination, and the hyperalgesia through Aδ-fibers following cuprizone-induced demyelination was mediated by LPA5 signaling. These data suggest that LPA5 signaling may play a key role in the mechanisms underlying neuropathic pain following demyelination in the brain. 相似文献
110.
Tetsu Tanouchi Takachika Shimizu Keisuke Fueki Masatake Ino Naufumi Toda Nodoka Manabe 《European spine journal》2014,23(3):635-640