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51.
Pérez C Fernández-Agulló T De Solís AJ Ros M Andrés A Carrascosa JM 《Clinical and experimental pharmacology & physiology》2008,35(3):256-261
1. Inhibitors of intestinal glucosidases have been shown to improve glycaemic control in diabetic and obese humans and animals. In the present study, we have investigated the effect of 3 months treatment with acarbose on adiposity, food intake and the modulation of hypothalamic neuropeptide Y (NPY) in obese diabetic Wistar (WDF) rats and the possible correlation between changes in overall insulin sensitivity and the level of circulating adipokines, leptin and adiponectin. In addition, we investigated the effect of acarbose on adipocyte insulin signalling. 2. Mature male WDF rats were randomly distributed to one of three treatment groups (no acarbose or 20 or 40 mg of acarbose/100 g diet). After 3 months, blood glucose, cholesterol, triglyceride, insulin, leptin and adiponectin were analysed. Insulin signalling was determined in isolated adipocytes as the stimulation of mitogen-activated protein kinase (MAPK) and Akt phosphorylation; the level of hypothalamic NPY was assessed by immunohistochemistry. 3. Acarbose-treated rats had lower levels of blood glucose, cholesterol, triglyceride, insulin and leptin and an increase in adiponectin compared with untreated animals. There were no changes in bodyweight and adiposity. Stimulation of adipocyte MAPK activity by insulin was higher in rats treated with both doses of acarbose, whereas higher stimulation of Akt phosphorylation was observed with the highest dose of acarbose. Although food intake was not significantly reduced in rats treated with acarbose, the acarbose-treated rats had lower NPY expression in the arcuate nucleus. 4. We conclude that the improvement in overall insulin sensitivity in WDF rats after prolonged acarbose treatment is paralleled by increases in circulating adiponectin and adipocyte insulin responsiveness. Acarbose neither decreases food intake nor reverts obesity, but decreases leptin levels and the expression of the orexigenic NPY in the hypothalamus. 相似文献
52.
Coralia Bleotu Carmen C. Diaconu Mihaela Chivu Irina Alexiu Simona M. Ruta Costin Cernescu 《Central European Journal of Medicine》2006,1(1):12-22
Despite the fact that a lot of methods have been developed for rapid virus detection, classic cell culture is still “the golden
standard”. The range of viruses that can be isolated and cultured in cell line systems is often limited by the susceptibility
of cells to support viral replication. Since the primary cell culture, the best cellular system available to support replication
of a large number of viruses, is very expensive and diffcult to obtain, cell lines, which are easier to manipulate, are commonly
used for virus growth and isolation.
In two previous papers we described the TV cell line initiated by our team from a laryngeal tumor, which harbors human papillomavirus
(HPV) gene sequences. In this paper we analyze its capacity to support virus replication. Depending on the virus, different
cytopathic effects were produced. Comparison of viral effect observed on this cell line with the effect obtained on other
cell lines has been performed. This cell line might be used in the clinical virology laboratory for virus isolation. 相似文献
53.
Coralia N. Mihu MD Christelle Kassis MD Elizabeth R. Ramos MD Ying Jiang MD Ray Y. Hachem MD Issam I. Raad MD 《Cancer》2010,116(22):5290-5296
BACKGROUND:
In vitro and in vivo studies suggested that combination of lipid formulation of amphotericin B (L‐AMB) and echinocandins may have a synergistic or additive effect against Aspergillus. Furthermore, clinical studies suggested that this combination may improve response of invasive aspergillosis (IA).METHODS:
Between August 1993 and June 2008, the authors identified a total of 159 patients with hematological malignancies who received salvage therapy for IA, with L‐AMB alone, echinocandins alone, or a combination of L‐AMB and echinocandins. Clinical characteristics, response to salvage therapy, and death up to 12 weeks after initiation of salvage therapy were retrospectively determined for all patients.RESULTS:
Seventy patients received salvage therapy with L‐AMB, 18 patients received echinocandins alone (89% of whom received caspofungin), and 71 patients received the combination therapy of amphotericin B and echinocandins (90% of who received caspofungin). The 3 salvage treatment groups were comparable in regard to clinical characteristics; graft versus host disease was more frequently encountered in the echinocandin group, whereas more patients in the L‐AMB and combination groups had neutropenia and received immunotherapy. The response to salvage therapy was better in the echinocandin group (9% L‐AMB, 28% echinocandins, and 21% for combination therapy). The 3 groups had a comparable rate of Aspergillus‐related death (58%‐64%) and overall mortality (61%‐67%).CONCLUSIONS:
The combination of L‐AMB and echinocandins offered no advantage in terms of improving response or reducing mortality over either drug alone. Hence, this combination will only add to the cost of therapy without any improvement in outcome in patients with hematological malignancies. Cancer 2010. © 2010 American Cancer Society. 相似文献54.
55.
Eva Ciruelos María Apellániz-Ruiz Blanca Cantos Noelia Martinez-Jáñez Coralia Bueno-Muiño Maria-Jose Echarri Santos Enrech Juan-Antonio Guerra Luis Manso Tomas Pascual Cristina Dominguez Juan-Francisco Gonzalo Juan-Luis Sanz Cristina Rodriguez-Antona Juan-Manuel Sepúlveda 《The oncologist》2019,24(11):e1024-e1033
56.
Liton PB Challa P Stinnett S Luna C Epstein DL Gonzalez P 《Experimental gerontology》2005,40(8-9):745-748
The mechanisms responsible for the progressive malfunction of the trabecular meshwork (TM)-Schlemm's canal (SC) conventional outflow pathway tissue in primary open angle glaucoma (POAG) are still not fully understood. To determine whether POAG is characterized by an accumulation of senescent cells, similar to what has been described in other diseases, we have compared the levels of the senescence marker senescence-associated-beta-galactosidase (SA-beta-gal) in the outflow pathway cells of POAG and age-matched control donors. POAG donors demonstrated a statistically significant fourfold increase in the percentage of SA-beta-gal positive cells. These results suggest a potential role for cellular senescence in the pathophysiology of the outflow pathway. 相似文献
57.
Expression of Granulocyte-Macrophage Colony-Stimulating Factor Receptors in Human Prostate Cancer 总被引:5,自引:1,他引:4
58.
Effect of amphotericin B on capsule and cell size in Cryptococcus neoformans during murine infection 下载免费PDF全文
Zaragoza O Mihu C Casadevall A Nosanchuk JD 《Antimicrobial agents and chemotherapy》2005,49(10):4358-4361
Antifungal drugs can affect the cellular morphology of Cryptococcus neoformans in culture, which alters its interactions with phagocytes. We examined the effects of amphotericin B on C. neoformans during murine infection. The antifungal reduced capsule size and serum polysaccharide, which suggests an additional mechanism for amphotericin B's efficacy in cryptococcosis. 相似文献