全文获取类型
收费全文 | 1311篇 |
免费 | 122篇 |
国内免费 | 48篇 |
专业分类
耳鼻咽喉 | 26篇 |
儿科学 | 74篇 |
妇产科学 | 33篇 |
基础医学 | 110篇 |
口腔科学 | 36篇 |
临床医学 | 191篇 |
内科学 | 256篇 |
皮肤病学 | 27篇 |
神经病学 | 98篇 |
特种医学 | 163篇 |
外科学 | 169篇 |
综合类 | 30篇 |
预防医学 | 76篇 |
眼科学 | 13篇 |
药学 | 85篇 |
1篇 | |
中国医学 | 9篇 |
肿瘤学 | 84篇 |
出版年
2023年 | 4篇 |
2022年 | 6篇 |
2021年 | 18篇 |
2020年 | 12篇 |
2019年 | 11篇 |
2018年 | 27篇 |
2017年 | 24篇 |
2016年 | 34篇 |
2015年 | 37篇 |
2014年 | 53篇 |
2013年 | 57篇 |
2012年 | 40篇 |
2011年 | 45篇 |
2010年 | 55篇 |
2009年 | 76篇 |
2008年 | 38篇 |
2007年 | 63篇 |
2006年 | 40篇 |
2005年 | 37篇 |
2004年 | 25篇 |
2003年 | 31篇 |
2002年 | 25篇 |
2001年 | 42篇 |
2000年 | 23篇 |
1999年 | 31篇 |
1998年 | 75篇 |
1997年 | 88篇 |
1996年 | 60篇 |
1995年 | 55篇 |
1994年 | 39篇 |
1993年 | 43篇 |
1992年 | 18篇 |
1991年 | 12篇 |
1990年 | 18篇 |
1989年 | 28篇 |
1988年 | 26篇 |
1987年 | 31篇 |
1986年 | 17篇 |
1985年 | 17篇 |
1984年 | 13篇 |
1983年 | 14篇 |
1982年 | 13篇 |
1981年 | 9篇 |
1980年 | 9篇 |
1978年 | 8篇 |
1977年 | 11篇 |
1976年 | 5篇 |
1975年 | 3篇 |
1972年 | 3篇 |
1968年 | 2篇 |
排序方式: 共有1481条查询结果,搜索用时 15 毫秒
41.
42.
43.
44.
Tamar Mendelson Steven C. Sheridan Laura K. Clary 《Research in social & administrative pharmacy》2021,17(6):1110-1118
BackgroundYouth of color from low-income urban communities are crucial participants in research, as their involvement can shape effective, culturally responsive interventions and policy to promote youth health and well-being. These young people, however, are an often-neglected research population, due in part to perceived challenges associated with their inclusion as well as marginalized communities’ justifiable mistrust of research.ObjectivesBased on our experience conducting a school-based randomized intervention trial in Baltimore, Maryland, we present strategies for conducting research with low-income, urban youth of color. We discuss strategies in three domains: university-community partnership development, participant recruitment, and participant retention.MethodsWe reviewed partnership building and recruitment strategies employed by our team across four years of trial implementation and evaluated success of participant retention at our final survey timepoint.ResultsPartnership building was facilitated by selection of a study design that maximized benefits for all participants, promotion of capacity building at partner institutions, and attention to research staff hiring and training practices. Effective study recruitment strategies included personal contact with parents and close cooperation between school personnel and study staff. Providing incentives and collecting multiple types of participant contact information contributed to increased retention rates. On average, those who participated in the final survey timepoint were less likely to be male and Latinx and exhibited more favorable baseline mental health than those who did not, suggesting differential attrition based on youth characteristics.ConclusionsLessons learned from this school-based trial can be applied more broadly to research with low-income urban youth of color. Researchers should strive to maximize scientific rigor, minimize harm to vulnerable adolescents and their communities, promote positive research experiences for young people, and provide concrete benefits to those who participate. 相似文献
45.
Although there has been increasing recognition of psychiatric comorbidity in epilepsy, most research and attention in this area has focused on depression. However, comorbid anxiety in epilepsy is highly prevalent, affecting more than 40 % of patients in some reports. Many important outcomes are significantly impacted by anxiety in epilepsy, including quality of life, mortality, and seizure status. Recent evidence from epidemiologic studies suggests a bidirectional association of anxiety and epilepsy, and there is mounting evidence for possible common pathophysiology underlying anxiety and epilepsy. Despite this importance, anxiety is under-recognized and undertreated in clinical practice. A variety of anxiety symptoms are seen in epilepsy, including symptoms exclusively before, during or after seizures (peri-ictal anxiety), symptoms resembling primary anxiety disorders, and anxiety directly related to epilepsy or its treatment. Key therapeutic approaches include pharmacotherapy or cognitive behavioral therapy for most forms of interictal anxiety and better seizure control for peri-ictal anxiety. 相似文献
46.
Colorectal cancer is a common malignancy and often presents with synchronous or metachronous distant spread. For patients with hepatic metastases, resection is the principal curative option. Liberalization of the indications for hepatic resection has introduced a number of challenges related to the size, distribution, and number of metastases as well as the condition of the future liver remnant. Advances in systemic therapy have solidified its role as both an important adjunct to surgery and also for many patients as a mechanism to facilitate resection. In patients whose disease is marginally resectable as a consequence of the distribution of hepatic lesions that precludes complete resection or out of concern for the future liver remnant, a number of strategies have been advocated, including prehepatectomy systemic therapy, staged surgical approaches, ablative technologies, and preoperative portal vein embolization. It is the purpose of this review to discuss ways in which to optimize the treatment of patients with potentially resectable disease, specifically those who are judged to have “borderline” resectable situations. 相似文献
47.
48.
49.
Factor V Quebec revisited 总被引:2,自引:5,他引:2
Factor V Quebec has been described as a bleeding disorder that exhibits an autosomal dominant inheritance pattern and presents severe bleeding after trauma. Two members of a fourth-generation (IV.13 and IV.15) Canadian family have been studied in detail and are the subject of this report. Their clinical presentations and histories have been described previously (Tracy et al: J Clin Invest 74:1221, 1984). Persistent abnormalities include mild thrombocytopenia and defective platelet factor V. Plasma factor V is present at near normal concentration and is fully functional. Thus, the bleeding diathesis appears to reflect the absence of platelet factor V activity. The recent report (Hayward et al: Blood 84:110a, 1994 [suppl, abstr]) of multimerin deficiency in these individuals led us to reevaluate these patients. Western blot analyses of platelet lysates developed with a variety of monoclonal antibodies show that the alpha-granule proteins, fibrinogen, von Willebrand factor, factor V and osteonectin are decreased in concentration and significantly degraded in the platelets of these patients. Thrombospondin, while not degraded, is substantially decreased. In contrast, platelet factor 4 and beta-thromboglobulin do not appear to be affected. These observations suggest that the alpha- granules are correctly assembled but the contents are subsequently subjected to proteolytic degradation. The results indicate that factor V Quebec disorder is probably associated with a generalized defect that leads to degradation of most proteins of the alpha-granules. 相似文献