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991.
Anne Elizabeth Chambers Craig Fairbairn Marco Gaudoin Walter Mills Irene Woo Raj Pandian Frank Z. Stanczyk Karine Chung Subhasis Banerjee 《Reproductive biomedicine online》2019,38(2):159-168
Research question
Circulating soluble LH-HCG receptor (sLHCGR) is a first-trimester marker for screening pregnancy pathologies and predicts premature or multiple births before fertility treatment. Oestradiol per oocyte at ovulation induction predicts IVF treatment outcomes. We asked whether sLHCGR levels are stable during fertility treatment and whether, alone or with oestradiol, they could improve prediction of fertility treatment outcomes.Design
Serum sLHCGR, anti-Müllerian hormone [AMH] and oestradiol were measured in patients undergoing IVF. Antral follicle count before ovarian stimulation and oocyte yield were used to establish sLHCGR– oocyte ratio (SOR), sLHCGR– antral follicle ratio (SAR), oestradiol at trigger per oocyte (oestradiol–oocyte ratio [EOR]) and oestradiol at trigger per antral follicle (oestradiol–antral follicle ratio [EAR]).Results
The relatively stable sLHCGR was negatively related to AMH when oocyte yield was high. The sLHCGR levels were proportional (r?=?0.49) to oestradiol at early cycle (day-3). Pregnancy and live birth were highest at low sLHCGR (≤1.0 pmol/ml) and SOR (≤ 0.1 pmol/ml/oocyte). A total of 86–89% of live births in IVF treatment were within the cut-off parameters of SAR and SOR (0.5 pmol/ml) and EAR and EOR (380 pg/ml). For failed pregnancy, age, SOR and EOR together had positive and negative predictive values of 0.841 and 0.703, respectively.Conclusions
sLHCGR levels are negatively related to AMH when oocyte yield is high. High early cycle sLHCGR is associated with elevated day-3 oestradiol. Low sLHCGR and SOR are indicators of increased clinical pregnancy and live birth rates. Patient age and SOR, combined with EOR, might improve prediction of IVF treatment outcomes. 相似文献992.
Wenyue Zhu Queenie Yeung David Chan Ling Chi Jin Huang Qiong Wang Jacqueline Chung Tin-Chiu Li 《Reproductive biomedicine online》2019,38(5):683-690
Research question
Does the blastocyst development stage on embryo transfer day affect serum β-human chorionic gonadotrophin (β-HCG) concentration 9 and 16 days after embryo transfer in women whose pregnancy progresses beyond 13 weeks?Design
Retrospective study involving 204 cases where pregnancy progressed beyond 13 weeks of single blastocyst transfer in fresh (n = 66) or frozen embryo transfer (FET) (n = 138) cycles from January 2015 to September 2016.Results
β-HCG concentrations 9 and 16 days after embryo transfer in FET cycles (median 223 IU/l and 4378 IU/l, respectively) were significantly (P < 0.001) higher than in fresh cycles (157 IU/l and 2813 IU/l). Among fresh cycles, faster-growing blastocysts (expanded?+?hatching?+?hatched blastocysts) produced significantly (P < 0.001) higher β-HCG concentrations 9 days after embryo transfer (191 IU/l) than slower-growing blastocysts (cavitating?+?full blastocyst, 106 IU/l); however no significant difference was found between the faster- and slower-growing groups by day 16 (2359 IU/l and 3025 IU/l, respectively). Among FET cycles, there was no difference in β-HCG concentration between blastocysts of different development stages 9 and 16 days after transfer.Conclusions
Faster-growing blastocysts produced significantly higher serum β-HCG concentrations 9 days after transfer than slower-growing blastocysts in fresh cycles, but the difference was not significant by day 16 after transfer. Also, β-HCG concentrations 9 and 16 days after embryo transfer in FET cycles were higher than in fresh embryo transfer cycles. Interpretation of β-HCG results 9 days after blastocyst transfer should consider the blastocyst growth rate and whether fresh or cryopreserved embryo was transferred. 相似文献993.
Thavasyappan Thambi V.G. Deepagan Hong Yeol Yoon Hwa Seung Han Seol-Hee Kim Soyoung Son Dong-Gyu Jo Cheol-Hee Ahn Yung Doug Suh Kwangmeyung Kim Ick Chan Kwon Doo Sung Lee Jae Hyung Park 《Biomaterials》2014
Hypoxia is a condition found in various intractable diseases. Here, we report self-assembled nanoparticles which can selectively release the hydrophobic agents under hypoxic conditions. For the preparation of hypoxia-responsive nanoparticles (HR-NPs), a hydrophobically modified 2-nitroimidazole derivative was conjugated to the backbone of the carboxymethyl dextran (CM-Dex). Doxorubicin (DOX), a model drug, was effectively encapsulated into the HR-NPs. The HR-NPs released DOX in a sustained manner under the normoxic condition (physiological condition), whereas the drug release rate remarkably increased under the hypoxic condition. From in vitro cytotoxicity tests, it was found the DOX-loaded HR-NPs showed higher toxicity to hypoxic cells than to normoxic cells. Microscopic observation showed that the HR-NPs could effectively deliver DOX into SCC7 cells under hypoxic conditions. In vivo biodistribution study demonstrated that HR-NPs were selectively accumulated at the hypoxic tumor tissues. As consequence, drug-loaded HR-NPs exhibited high anti-tumor activity in vivo. Overall, the HR-NPs might have a potential as nanocarriers for drug delivery to treat hypoxia-associated diseases. 相似文献
994.
Kyeong Soo Lee Chang Nyol Paik Woo Chul Chung Kang Moon Lee Sung Hoon Jung Jae Wuk Kawk Ji Han Jung Jun Hyun Baik 《Gut and liver》2010,4(2):287-291
Buerger''s disease, or thromboangiitis obliterans, is a nonatherosclerotic inflammatory disease affecting the small- and medium-sized arteries and veins of the extremities (arms, hands, legs, and feet). It is most common in the Orient, Southeast Asia, India, and the Middle East, and usually affects men aged between 20 and 40 years, although it is becoming more common in women. It is well established that most such patients smoke heavily and experience an improvement in symptoms following smoking cessation. Mesenteric involvement in Buerger''s disease is extremely rare; however, we describe herein two cases of colon ischemia in patients who were previously diagnosed with lower-extremity Buerger''s disease. In one case, the patient developed colonic obstruction, and surgical resection was performed. Histopathologic findings were compatible with the chronic stage of Buerger''s disease. In the other case, angiography revealed abrupt occlusion of the inferior mesenteric artery with numerous collateral vessels, just like the corkscrew appearance found in the extremities. If patients with established Buerger''s disease of the extremities complain of gastrointestinal symptoms, early interventional diagnosis should be performed to prevent intestinal obstruction and gangrene. 相似文献
995.
Jin Young Yoon Jung Min Lee Do Young Kim Gi Hong Choi Young Nyun Park Joo Won Chung Eun Young Kim Jun Yong Park Sang Hoon Ahn Kwang-Hyub Han Chae Yoon Chon 《Gut and liver》2010,4(2):245-249
An undifferentiated (embryonal) liver sarcoma (ULS) originates from a primitive mesenchymal cell, with a predilection for childhood and very rare occurrence in adults. We report a case of a ULS that was incidentally found in a 53-year-old female. Our case was initially interpreted as a large hydatid cyst, which was later suspected to be a neoplastic lesion because its size was increasing and a solid portion was newly detected after shrinkage of the cyst following drainage. The patient underwent successful right hepatic lobectomy with complete resection, and is currently disease-free without adjuvant therapy. Although it is difficult to diagnose a hepatic cyst as a ULS due to its rare occurrence in adulthood and lack of specific findings, its possibility should be considered, especially when its size is increasing, because early diagnosis and curative resection are necessary for a favorable outcome. 相似文献
996.
997.
Chronic severe asthma remains a challenging clinical problem despite the availability of modern treatments. Relative corticosteroid insensitivity is present in severe asthma and may contribute to continuing disease severity. Advances in the understanding of molecular mechanisms underlying corticosteroid insensitivity may yield new therapeutic targets. Furthermore, aetiological factors for corticosteroid insensitivity have been identified and these may be amenable to modification. 相似文献
998.
999.
Hae Won Lee Kyung-Suk Suh Joohyun Kim Woo Young Shin Nam-Joon Yi Hwan Jun Jae Jin Wook Chung So Won Oh Keon Wook Kang Kuhn Uk Lee 《Korean journal of radiology》2010,11(4):485-489
Although liver transplantation (LT) is the only effective treatment option for hepatopulmonary syndrome (HPS), the post-LT morbidity and mortality have been high for patients with severe HPS. We performed post-LT embolotherapy in a 10-year-old boy who had severe type I HPS preoperatively, but he failed to recover early from his hypoxemic symptoms after an LT. Multiple embolizations were then successfully performed on the major branches that formed the abnormal vascular structures. After the embolotherapy, the patient had symptomatic improvement and he was discharged without complications. 相似文献
1000.