全文获取类型
收费全文 | 5390篇 |
免费 | 520篇 |
国内免费 | 87篇 |
专业分类
耳鼻咽喉 | 42篇 |
儿科学 | 125篇 |
妇产科学 | 248篇 |
基础医学 | 694篇 |
口腔科学 | 65篇 |
临床医学 | 564篇 |
内科学 | 1058篇 |
皮肤病学 | 92篇 |
神经病学 | 429篇 |
特种医学 | 346篇 |
外科学 | 723篇 |
综合类 | 120篇 |
预防医学 | 319篇 |
眼科学 | 101篇 |
药学 | 397篇 |
中国医学 | 26篇 |
肿瘤学 | 648篇 |
出版年
2023年 | 33篇 |
2022年 | 53篇 |
2021年 | 126篇 |
2020年 | 98篇 |
2019年 | 178篇 |
2018年 | 181篇 |
2017年 | 123篇 |
2016年 | 141篇 |
2015年 | 182篇 |
2014年 | 215篇 |
2013年 | 322篇 |
2012年 | 370篇 |
2011年 | 376篇 |
2010年 | 257篇 |
2009年 | 201篇 |
2008年 | 283篇 |
2007年 | 285篇 |
2006年 | 254篇 |
2005年 | 270篇 |
2004年 | 248篇 |
2003年 | 214篇 |
2002年 | 206篇 |
2001年 | 175篇 |
2000年 | 148篇 |
1999年 | 149篇 |
1998年 | 50篇 |
1997年 | 42篇 |
1996年 | 34篇 |
1995年 | 31篇 |
1994年 | 21篇 |
1993年 | 28篇 |
1992年 | 83篇 |
1991年 | 81篇 |
1990年 | 55篇 |
1989年 | 52篇 |
1988年 | 54篇 |
1987年 | 51篇 |
1986年 | 44篇 |
1985年 | 48篇 |
1984年 | 41篇 |
1983年 | 23篇 |
1982年 | 21篇 |
1981年 | 13篇 |
1980年 | 13篇 |
1979年 | 12篇 |
1978年 | 16篇 |
1977年 | 12篇 |
1975年 | 12篇 |
1974年 | 11篇 |
1969年 | 9篇 |
排序方式: 共有5997条查询结果,搜索用时 17 毫秒
81.
82.
83.
Kuo-Kang Feng Chun-Yang Huang Chen-Yuan Hsiao Tsung-Hsing Lee Tzu-Ting Kuo Chun-Che Shih Chiao-Po Hsu 《Journal of the Chinese Medical Association》2013,76(6):350-353
Nutcracker syndrome (NCS) is a rare pathology manifested by pain or hematuria in males and females alike. It can be easily overlooked, and should be considered in young men or women with symptoms of extended duration. We present a case of a 54-year-old female with chronic lower abdominal pain radiating to the left thigh of 4 years in duration. Computed tomography (CT) eventually revealed engorged left renal, gonadal, and uterine veins due to compression between the superior mesenteric artery (SMA) and the abdominal aorta, consistent with NCS. After a successful endovascular stenting and a 6-month period of antiplatelet and anticoagulant therapy, the patient returned to stable health. NCS, while rare, should be suspected in patients of both sexes with persistent pain or hematuria. 相似文献
84.
85.
ObjectiveStudies have shown that some specific body measures are associated with the occurrence of cancers. Few studies have demonstrated the relationship with more comprehensive approaches. This study aims to explore body measures and the combinations associated with internal organ cancers.MethodsThree-dimensional anthropometric body surface scanning data collected 10,215 participants from the health examination department in a medical center of Taiwan during 2000–2010. Follow-up was conducted for an average of 8 years, and 244 internal organ cancer cases were identified.ResultsAn increased risk of internal organ cancers was observed among the subjects with larger waist circumference/smaller thigh circumference, in which waist-to-thigh ratio (WTR) was constructed. Comparing the subjects in the fourth quartile for WTR to the subjects in the first quartile with multiple Cox regression analysis yielded a hazard ratio of 1.842 (95% confidence interval, 1.131~2.999). The association between WTR quartile and internal organ cancers was stronger among male participants, older participants, and participants with chronic conditions.ConclusionsThe study has revealed that WTR is the most significant predictor for the occurrence of cancer in Asian populations. Because it is easy to measure and open to modification, WTR may be more useful in clinical and preventive medicine in the future. 相似文献
86.
87.
88.
89.
Chi‐Yuan Chen Shih‐Hwa Chiou Chih‐Yang Huang Chia‐Ing Jan Shu‐Chun Lin Wen‐Yuan Hu Shiu‐Huey Chou Chung‐Ji Liu Jeng‐Fan Lo 《The Journal of pathology》2009,219(3):347-355
Human tumourous imaginal disc (Tid1), a human homologue of the Drosophila tumour suppressor protein Tid56, is involved in multiple intracellular signalling pathways such as apoptosis, cell proliferation, and cell survival. Here, we investigated the anti‐tumourigenic activity of Tid1 in head and neck squamous cell carcinoma (HNSCC) in vitro and in vivo. Firstly, the clinical association between Tid1 expression and progression of HNSCC was explored. It was found that expression of Tid1 was negatively associated with tumour status, recurrence, and survival prognosis using immunohistochemical analysis of primary HNSCC patient tumour tissue. Secondly, ectopic expression of Tid1 in HNSCC cells was shown to significantly inhibit cell proliferation, migration, invasion, anchorage‐independent growth, and xenotransplantation tumourigenicity. Thirdly, we showed that overexpression of Tid1 attenuated EGFR activity and blocked the activation of AKT in HNSCC cells, which are known to be involved in the regulation of survival in HNSCC cells. On the other hand, ectopic expression of constitutively active AKT greatly reduced apoptosis induced by Tid1 overexpression. Together, these findings suggest that Tid1 functions as a tumour suppressor in HNSCC tumourigenesis. Copyright © 2009 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd. 相似文献
90.
Chang NC Shih CM Bi WF Lai ZY Lin MS Wang TC 《Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy》2002,16(2):141-147
To clarify whether fosinopril monotherapy can improve left ventricular diastolic function (LVDF) in young mildly hypertensives without hypertrophy, we studied 66 patients (pts) with diastolic blood pressure 90–100 mmHg, aged <45 years, with normal 2-dimensional echocardiography (2-D echo), and impaired DF. Impaired DF was defined as a Doppler transmitral early (E) to atrial (A) filling velocity ratio (E/A ratio) <1. Thirty-eight pts were selected for fosinopril monotherapy. Mean age was 36 years. Duration of documented hypertension was 5.4 years. Mean daily dose of fosinopril was 20 mg. Twenty-eight controls were treated with hydrochlorothiazide and hydralazine combination. Sixty-six age- and sex-matched healthy subjects served to establish normal reference values of 2-D and Doppler echo measurements. All hypertensives were treated for 30 months and re-examined 4 weeks after cessation of treatment. The fosinopril-treated group showed improvements in transmitral E (52 ± 8 cm/s, vs. 61 ± 9 cm/s, p < 0.01), A (56 ± 9 cm/s, vs. 47 ± 6 cm/s, p < 0.05), and E/A ratio (0.93 ± 0.16, vs. 1.29 ± 0.18, p < 0.01). Moreover, the early to atrial velocity-time integral ratio (1.31 ± 0.10, vs. 2.24 ± 0.10, p < 0.001) improved. The pulmonary venous flow pattern normalized after fosinopril therapy. LV mass index, relative wall thickness, LV dimension, left atrial dimension, fractional shortening, heart rate, and body mass index did not change. The hydrochlorothiazide-hydralazine combination-treated group did not show an improved diastolic function. It is concluded that long-term fosinopril monotherapy leads to an improvement of impaired LVDF in young mildly hypertensives without hypertrophy. 相似文献