带控制阀种植牙手术骨粉收集器的研制及临床应用

目的 介绍自行研制的带控制阀种植牙手术骨粉收集器,并观察其临床应用效果.方法 选取2008年5月至2009年10月38例牙种植患者,应用自制的骨粉收集器收集种植窝制备时产生的骨碎屑,并将其用于修复种植体周围骨缺损,其中开窗式骨缺损29处,唇颊(舌)侧种植体颈部角形缺损23处.结果 所有病例术后均无创口感染及裂开,原缺损处局部形态饱满,牙龈无明显退缩,X线片示种植体与周围牙槽骨形成良好的骨结合.结论 应用自制骨粉收集器收集的骨粉修复种植体周围小型骨缺损效果良好,使用方便,具有良好的应用前景.

Abstract：

Objective To introduce a self-developed bone collector designed by the authors and evaluate its effect in clinical application. Methods A self-developed bone collector was used in 38 patients who underwent the dental implant operation from May 2008 to October 2009. During the operation the bone particles were harvested, which was used for the reconstruction of the bone defects around the implant simultaneously. The defects were fenestrate in 29 regions and triangle in 23 regions on buccal or lingual side of the dental implants. Results All cases had no surgical wound infection and dehiscence 7-10 days after operation. Three to six months after implantation, the X-ray showed that all the dental implants had perfect osseointergration and the alveolar bone were successfully augmented. Conclusions Bone debris harvested by self-developed bone collector could repair small peri-implant bone defects, which is simple to use in clinic.     

Study of the location of mandibular mental foremen in modern and neolithic adult]

37 cases of mandible of Neolithic adult that both sexes without missing teeth,alveolar bone were studied.The result showed that the location of the mental foramen below the apex of the lower second premolar was the most common(67.97%) in the modern adult,and the location of the mental foramen below between the apex of the lower second premolar and the first molar was the most common (64.86%) in the neolithic adult.     

Cloning of hamster osteopontin and expression distribution in normal tissues and experimentally induced oral squamous-cell carcinoma

Osteopontin (OPN) is a non-collagenous extracellular matrix (ECM) protein expressed and secreted by several human cancers. This study investigated the expression pattern of OPN during development of oral squamous-cell carcinoma by using 7,12-dimethylbenz[a]anthracene (DMBA)-induced squamous-cell carcinomas in buccal pouch of syrian golden hamsters. We first identified the hamster OPN cDNA sequence by screening of a hamster calvariae cDNA library with a rat OPN cDNA probe. The resulting 1,449 bp of hamster OPN cDNA led to a deduced protein sequence of 305 amino acids containing several putative binding sites to integrins, CD44 receptors, calcium ions and hydroxyapatite, as well as multiple sites for phosphorylation, glycosylation and sulphation. Hamster OPN cDNA was then used as a probe to analyze the expression of OPN mRNA by Northern blot and in situ hybridization analyses of normal and malignant tissues. OPN mRNA was detected in several non-mineralized tissues as well as in mineralized tissues, but was not present in normal hamster buccal epithelium. DMBA-treated hamster buccal pouches expressed OPN mRNA as early as 4 weeks and displayed the highest level of expression at 15 weeks. The specimens treated with DMBA for 15 weeks exhibited histological features of squamous-cell carcinoma, presented microcrystalline deposits and showed OPN expression associated with malignant epithelium and tumor-associated macrophages. To summarize, our results suggest that buccal-pouch carcinogenesis of Syrian golden hamster may constitute an excellent experimental model to study the mechanisms by which OPN is associated with oral cancer pathogenesis, and to validate OPN-based therapeutic approaches to ameliorate oral cancer progression and metastasis.     

创伤性面瘫物理疗法的临床研究

目的 比较超短波加离子导入疗法（A组）与电刺激加离子导入疗法（B组）治疗创伤性面瘫的效果。方法 对39例创伤性面神经损伤患者进行临床对照研究，通过量化面神经功能评价、神经电图检查及面神经功能的主观评价比较面神经损伤的治疗效果。结果 创伤性面瘫以青年男性多见，损伤程度以中、重度为主；对于神经损伤轻、中度患者,A组与B组均能促进神经恢复，B组神经功能开始恢复时间早于A组。对于神经损伤重度患者，A组与B组神经恢复率高于对照组，两组均不能减少并发症出现率。结论 超短波加离子导入疗法与电刺激加离子导入疗法均能促进面神经损伤的恢复，但对于减少并发症发生率并无帮助。     

九种金属离子的细胞毒性评价

对与口腔科常用合金材料有关的9种金属离子(Fe、Ni、Ti、Mn、Mo、Cu、Co、Cr、V)的细胞毒性进行了测定和比较。将L-929细胞培养7天后,求得各种离子不同浓度时的细胞相对增殖率,并转换成六级评分以评价试料的毒性程度。结果表明:在0.5～10ppm离子浓度范围,Mo离子无明显毒性;Mn离子虽有一定毒性,但其浓度变化对毒性程度无影响,V离子显示了较强的毒性;其它离子的毒性则随浓度改变而有不同程度的变化。     

铸造义齿中网状支架的设计

铸造义齿中网状支架的设计李景辉，宋培智，陈官辉，季秋杰，卢玉春，高银凤在可摘局部义齿修复中，网状支架的合理设计既增加了义齿的强度，又具有传递咬力、分散力、保护口腔内软硬组织的功能［１］。常用形态为园孔形、方格形、楼梯的，网状形、三角形、倒锥形、栅栏形...     

Clinical evaluation of different treatment methods for oral submucous fibrosis. A 10-year experience with 150 cases

Over a 10-year period (1982–1991), a total of 150 patients divided into two groups with varying degrees of oral submucous fibrosis (OSF) were treated by either medical or surgical therapies. Medical treatment involved (a) conservative oral administration of vitamin B-complex, buflomedial hydrochloride and topical triamcinolone acetonide 0.1%, or (b) conventional submucosal injections of a combination of dexamethasone and hyaluronidase, or (c) a combination of both (a) and (b). The surgical group was treated by the excision of fibrotic tissues and covering the defect with split-thickness skin, fresh human amnion, or buccal fat pad (BFP) grafts. Treatment was chosen according to the stage of clinical progression to gain maximal interincisal distance (ID). The cases were followed up by monthly examinations for at least two years, or when possible even longer. A combination of (a) and (b) medical treatment was satisfactory in cases of mild impairment (ID > 20 mm) but in the long term it led to symptomatic relief only. Surgical therapy, on the other hand, when accepted by the patients, led to a significant improvement of trismus in cases of severe limitation (ID < 20 mm). Following this strategy, an additional ID increase was observed in all patients. BFP grafting was particularly successful in diminishing scarring after two years as compared with the other two grafts. Together with a cessation of the betel quid chewing habit before and after therapy, these treatment regimens combined with daily mouth opening exercises were found to be necessary to manage OSF cases in early and advanced stages of progression.