全文获取类型
收费全文 | 2346470篇 |
免费 | 174890篇 |
国内免费 | 3319篇 |
专业分类
耳鼻咽喉 | 32049篇 |
儿科学 | 75892篇 |
妇产科学 | 62685篇 |
基础医学 | 348165篇 |
口腔科学 | 63620篇 |
临床医学 | 211342篇 |
内科学 | 457270篇 |
皮肤病学 | 51727篇 |
神经病学 | 185263篇 |
特种医学 | 88006篇 |
外国民族医学 | 489篇 |
外科学 | 353857篇 |
综合类 | 47508篇 |
现状与发展 | 12篇 |
一般理论 | 848篇 |
预防医学 | 182731篇 |
眼科学 | 54325篇 |
药学 | 175097篇 |
11篇 | |
中国医学 | 4575篇 |
肿瘤学 | 129207篇 |
出版年
2021年 | 18978篇 |
2019年 | 19538篇 |
2018年 | 27058篇 |
2017年 | 20358篇 |
2016年 | 22745篇 |
2015年 | 25639篇 |
2014年 | 36095篇 |
2013年 | 53952篇 |
2012年 | 74674篇 |
2011年 | 79406篇 |
2010年 | 47055篇 |
2009年 | 44565篇 |
2008年 | 74607篇 |
2007年 | 79478篇 |
2006年 | 80293篇 |
2005年 | 77777篇 |
2004年 | 74367篇 |
2003年 | 71690篇 |
2002年 | 69362篇 |
2001年 | 108737篇 |
2000年 | 111450篇 |
1999年 | 93494篇 |
1998年 | 26990篇 |
1997年 | 23659篇 |
1996年 | 24054篇 |
1995年 | 22715篇 |
1994年 | 20893篇 |
1993年 | 19712篇 |
1992年 | 72000篇 |
1991年 | 70069篇 |
1990年 | 68391篇 |
1989年 | 65663篇 |
1988年 | 60302篇 |
1987年 | 59125篇 |
1986年 | 55217篇 |
1985年 | 53005篇 |
1984年 | 39311篇 |
1983年 | 33396篇 |
1982年 | 19858篇 |
1979年 | 35866篇 |
1978年 | 25651篇 |
1977年 | 21230篇 |
1976年 | 20332篇 |
1975年 | 21816篇 |
1974年 | 26148篇 |
1973年 | 24802篇 |
1972年 | 23200篇 |
1971年 | 22037篇 |
1970年 | 20247篇 |
1969年 | 19315篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
141.
F. Giovanardi F. Nudo Q. Lai M. Garofalo A. Consolo E. Choppin De Janvry G.A. Arroyo Murillo P. Ursi D. Stabile F. Melandro P.B. Berloco R. Pretagostini L. Poli 《Transplantation proceedings》2019,51(1):128-131
Background
Arterial vascular anomalies in patients undergoing kidney transplantation (KT) are correlated with a higher incidence of early surgical complications, potentially causing graft loss. Arterial reconstruction allows patients to overcome these surgical challenges, thus minimizing the risk of poor outcomes. The aim of the present study is to retrospectively investigate the safety and effectiveness of the multiple arterial reconstruction technique with a Teflon patch in case of an unavailable aortic patch: to do so, surgical complications, graft function, and patient survival were evaluated.Methods
During the period January 2009 to August 2016, 202 adult deceased-donor KTs were performed at our center. Group A (n = 27; reconstruction of multiple arteries) and Group B (n = 175; control group) were compared.Results
No differences were observed between the 2 groups in terms of early postoperative course, with no vascular complication observed in Group A. No vascular patch infections were reported, nor longer cold ischemia time rates. Similarly, long-term survival rates were similar between the 2 groups.Conclusions
The Teflon-patch arterial reconstruction technique appears to be safe and effective, with an acceptable balance of benefits and potential risks of using a prosthetic material. Studies based on larger series are needed to further validate this approach. 相似文献142.
Paul J. Devlin Brian W. McCrindle James K. Kirklin Eugene H. Blackstone William M. DeCampli Christopher A. Caldarone Ali Dodge-Khatami Pirooz Eghtesady James M. Meza Peter J. Gruber Kristine J. Guleserian Bahaaladin Alsoufi Linda M. Lambert James E. OBrien Erle H. Austin Jeffrey P. Jacobs Tara Karamlou 《The Journal of thoracic and cardiovascular surgery》2019,157(2):684-695.e8
Objective
Arch obstruction after the Norwood procedure is common and contributes to mortality. We determined the prevalence, associated factors, and practice variability of arch reintervention and assessed whether arch reintervention is associated with mortality.Methods
From 2005 to 2017, 593 neonates in the Congenital Heart Surgeons' Society Critical Left Heart Obstruction cohort underwent a Norwood procedure. Median follow-up was 3.7 years. Multivariable parametric models, including a modulated renewal analysis, were performed.Results
Of the 593 neonates, 146 (25%) underwent 218 reinterventions for arch obstruction after the Norwood procedure: catheter-based (n = 168) or surgical (n = 50) at a median age of 4.3 months (quartile 1-quartile 3, 2.6-5.7). Interdigitation of the distal aortic anastomosis was protective against arch reintervention. Development of ≥ moderate tricuspid valve regurgitation and right ventricular dysfunction at any point was associated with arch reintervention. Nonsignificant variables for arch reintervention included shunt type and preoperative aortic measurements. Surgical arch reintervention was protective against arch reintervention, but transcatheter reintervention was associated with increased reintervention. Arch reintervention was not associated with increased mortality. There was wide institutional variation in incidence of arch reintervention (range, 0-40 reinterventions per 100 years patient follow-up) and in preintervention gradient (range, 0-64 mm Hg).Conclusions
Interdigitation of the distal aortic anastomosis during the Norwood procedure decreased the risk of arch reintervention. Surgical arch reintervention is more definitive than transcatheter. Arch reintervention after the Norwood procedure is not associated with increased mortality. Serial surveillance for arch obstruction, integrated with changes in right ventricular function and tricuspid valve regurgitation, is recommended after the Norwood procedure to improve outcomes. 相似文献143.
144.
145.
Focal hyperhidrosis secondary to eccrine naevus successfully treated with botulinum toxin type A
下载免费PDF全文
![点击此处可从《Clinical and experimental dermatology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Eccrine naevus (EN) is a rare skin hamartoma included in the organoid group of epidermal naevi, histologically defined as focal hyperplasia and/or hypertrophy of eccrine glands. Clinically, EN usually presents as hyperhidrotic patches with no visible skin changes, frequently located on the forearms. The decision to treat EN or not usually depends on the grade of hyperhidrosis, but there is no therapeutic consensus because of the rarity of this condition. We present a case diagnosed as EN in an adult patient with severe localized hyperhidrosis, which was successfully treated with botulinum toxin. 相似文献
146.
147.
148.
149.
Enrique Luengo Izaskun Buendia Cristina Fernndez‐Mendívil Paula Trigo‐Alonso Pilar Negredo Patrycja Michalska Borja Hernndez‐García Cristina Snchez‐Ramos Juan A. Bernal Tsuneya Ikezu Rafael Len Manuela G. Lpez 《Journal of pineal research》2019,67(1)
Alterations in autophagy are increasingly being recognized in the pathogenesis of proteinopathies like Alzheimer's disease (AD). This study was conducted to evaluate whether melatonin treatment could provide beneficial effects in an Alzheimer model related to tauopathy by improving the autophagic flux and, thereby, prevent cognitive decline. The injection of AAV‐hTauP301L viral vectors and treatment/injection with okadaic acid were used to achieve mouse and human ex vivo, and in vivo tau‐related models. Melatonin (10 μmol/L) impeded oxidative stress, tau hyperphosphorylation, and cell death by restoring autophagy flux in the ex vivo models. In the in vivo studies, intracerebroventricular injection of AAV‐hTauP301L increased oxidative stress, neuroinflammation, and tau hyperphosphorylation in the hippocampus 7 days after the injection, without inducing cognitive impairment; however, when animals were maintained for 28 days, cognitive decline was apparent. Interestingly, late melatonin treatment (10 mg/kg), starting once the alterations mentioned above were established (from day 7 to day 28), reduced oxidative stress, neuroinflammation, tau hyperphosphorylation, and caspase‐3 activation; these observations correlated with restoration of the autophagy flux and memory improvement. This study highlights the importance of autophagic dysregulation in tauopathy and how administration of pharmacological doses of melatonin, once tauopathy is initiated, can restore the autophagy flux, reduce proteinopathy, and prevent cognitive decline. We therefore propose exogenous melatonin supplementation or the development of melatonin derivatives to improve autophagy flux for the treatment of proteinopathies like AD. 相似文献
150.