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排序方式: 共有10000条查询结果,搜索用时 484 毫秒
31.
Darren R. Feldman MD Yasser Ged MBBS Chung-Han Lee PhD Andrea Knezevic MS Ana M. Molina MD Ying-Bei Chen PhD Joshua Chaim DO Devyn T. Coskey MS Samuel Murray MS Satish K. Tickoo MD Victor E. Reuter MD Sujata Patil PhD Han Xiao MD Jahan Aghalar MD Arlyn J. Apollo MD Maria I. Carlo MD Robert J. Motzer MD Martin H. Voss MD 《Cancer》2020,126(24):5247-5255
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Zhengxian Huang Nan Xie Haichao Liu Yuehan Wan Yue Zhu Ming Zhang Yifan Tao Han Zhou Xiqiang Liu Jinsong Hou Cheng Wang 《Journal of oral pathology & medicine》2019,48(9):788-798
It has been suggested that tumour‐infiltrating lymphocytes (TILs) are associated with the progression of oral squamous cell carcinoma (OSCC). However, the prognostic value of TILs is inconclusive due to the heterogeneity of immune cells within the tumour microenvironment. In this meta‐analysis, we aimed to assess the prognostic value of TILs in OSCC. The PubMed, Cochrane, Embase, Scopus and Web of Science databases were searched up to April 20, 2019, and 33 studies were ultimately included in this meta‐analysis. Our pooled meta‐analysis showed that high infiltration of CD8+ TILs, CD45RO+ TILs and CD57+ TILs favoured better overall survival (OS). However, high infiltration of CD68+ macrophages and CD163+ macrophages was associated with poor prognosis in OSCC. These findings suggest that CD8+ TILs, CD45RO+ TILs, CD57+ TILs, CD68+ macrophages and CD163+ macrophages might serve as novel prognostic factors and therapeutic targets in OSCC. 相似文献
35.
H J Kim C H Kang Y T Kim S-W Sung J H Kim S M Lee C-G Yoo C-T Lee Y W Kim S K Han Y-S Shim J-J Yim 《The European respiratory journal》2006,28(3):576-580
Although surgical lung resection could improve prognosis in some patients with multidrug-resistant tuberculosis (MDR-TB), there are no reports on the optimal candidates for this surgery. The aim of the present study was to elucidate the prognostic factors for surgery in patients with MDR-TB. Patients who underwent lung resection for the treatment of MDR-TB between March 1993 and December 2004 were included in the present study. Treatment failure was defined as greater than or equal to two of the five cultures recorded in the final 12 months of treatment being positive, any one of the final three cultures being positive, or the patient having died during treatment. The variables that affected treatment outcomes were identified through univariate and multivariate logistic regression analysis. In total, 79 patients with MDR-TB were included in the present study. The treatment outcomes of 22 (27.8%) patients were classified as failure. A body mass index <18.5 kg x m(-2), primary resistance, resistance to ofloxacin and the presence of a cavitary lesion beyond the range of the surgical resection were associated with treatment failure. Low body mass index, primary resistance, resistance to ofloxacin and cavitary lesions beyond the range of resection are possible poor prognostic factors for surgical lung resection in multidrug-resistant tuberculosis patients. 相似文献
36.
Neprilysin基因在大鼠体外培养骨髓基质细胞中的表达 总被引:1,自引:1,他引:0
目的探讨人Neprilysin基因在小鼠MSCs中的表达情况。方法分离培养小鼠MSCs,采用分子克隆技术构建Neprilysin—pEGFP重组质粒,将此Neprilysin—pEGFP重组质粒用脂质体转染进MSCs中,在荧光倒置显微镜下观察该基因在MSCs中的表达效率。结果经酶切鉴定得到系列正确的重组Neprilysin—pEGFP。Neprilysin可在MSCs中表达且通过脂质体传染的效率是20%。结论获得了表达Neprilysin基因的骨髓基质细胞,为进一步探讨将该细胞用于阿尔茨海默病基因治疗的可能性研究提供了技术基础。 相似文献
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逍遥散出自《太平惠民和剂局方》,由当归、白芍药、柴胡、茯苓、白术、炙甘草、薄荷、煨姜组成。经前期综合征为临床常见的妇科病症,笔者近年来采用逍遥散加减治疗经前期综合征69例,疗效满意,现报道如下。 相似文献
39.
韩英 《中华实用中西医杂志》2006,19(5):540-541
脑梗塞是由于脑动脉粥样硬化和血栓形成使管腔闭塞,导致急性脑供血不足和脑组织局部坏死的临床症候群。其主要临床表现为偏瘫和失语。其中部分病人还可合并精神障碍。脑梗塞在我国十分常见,据文献报道:我国每年约有150余万人发生脑梗塞,因此认为做好脑梗塞病人的治疗和护理,尽快恢复其肢体和脑功能,具有十分重要的临床意义和社会意义。 相似文献
40.
Jung Yong Ahn In Bo Han Chang Ki Hong Jin Yang Joo 《Journal of clinical neuroscience》2006,13(8):872-875
Ruptured aneurysms of the distal anterior choroidal artery (AchA) are extremely rare and management is dictated by clinical presentation. This report describes a rare patient with a distal AchA aneurysm and subarachnoid and intraventricular haemorrhage. A 60-year-old woman presented with a sudden onset of severe headache and vomiting. No aneurysms could be found on initial angiograms. A repeat angiogram performed 10 days after admission demonstrated an aneurysm in a branch of the cisternal segment of the left AchA without a definite neck. Surrounding vessels showed multifocal stricture and dilatation. Microsurgical clipping was not performed because the patient died suddenly due to pulmonary failure. The aetiology of the aneurysm in this case and surgical strategy are discussed. 相似文献