全文获取类型
收费全文 | 1008篇 |
免费 | 37篇 |
国内免费 | 42篇 |
专业分类
儿科学 | 76篇 |
妇产科学 | 11篇 |
基础医学 | 83篇 |
口腔科学 | 25篇 |
临床医学 | 109篇 |
内科学 | 246篇 |
皮肤病学 | 21篇 |
神经病学 | 40篇 |
特种医学 | 254篇 |
外科学 | 47篇 |
综合类 | 46篇 |
预防医学 | 36篇 |
眼科学 | 15篇 |
药学 | 35篇 |
中国医学 | 3篇 |
肿瘤学 | 40篇 |
出版年
2023年 | 4篇 |
2022年 | 4篇 |
2021年 | 4篇 |
2020年 | 5篇 |
2019年 | 4篇 |
2018年 | 11篇 |
2017年 | 12篇 |
2016年 | 9篇 |
2015年 | 14篇 |
2014年 | 22篇 |
2013年 | 22篇 |
2012年 | 22篇 |
2011年 | 18篇 |
2010年 | 41篇 |
2009年 | 45篇 |
2008年 | 31篇 |
2007年 | 25篇 |
2006年 | 27篇 |
2005年 | 34篇 |
2004年 | 21篇 |
2003年 | 20篇 |
2002年 | 12篇 |
2001年 | 17篇 |
2000年 | 14篇 |
1999年 | 12篇 |
1998年 | 49篇 |
1997年 | 65篇 |
1996年 | 49篇 |
1995年 | 40篇 |
1994年 | 51篇 |
1993年 | 54篇 |
1992年 | 10篇 |
1991年 | 11篇 |
1990年 | 11篇 |
1989年 | 36篇 |
1988年 | 39篇 |
1987年 | 28篇 |
1986年 | 28篇 |
1985年 | 26篇 |
1984年 | 11篇 |
1983年 | 21篇 |
1982年 | 17篇 |
1981年 | 18篇 |
1980年 | 21篇 |
1979年 | 3篇 |
1978年 | 8篇 |
1977年 | 12篇 |
1976年 | 9篇 |
1975年 | 17篇 |
1948年 | 1篇 |
排序方式: 共有1087条查询结果,搜索用时 15 毫秒
971.
Value of chest radiography in excluding traumatic aortic rupture 总被引:7,自引:0,他引:7
Mirvis SE; Bidwell JK; Buddemeyer EU; Diaconis JN; Pais SO; Whitley JE; Goldstein LD 《Radiology》1987,163(2):487-493
A retrospective review of chest radiographs from 205 patients with blunt chest trauma who also underwent aortography was performed. Forty-one of the 205 had aortographically proved aortic rupture. Discriminant analysis of 16 radiographic signs indicated that the most discriminating signs were loss of the aorticopulmonary window, abnormality of the aortic arch, rightward tracheal shift, and widening of the left paraspinal line without associated fracture. No single or combination of radiographic signs demonstrated sufficient sensitivity to indicate all cases of traumatic aortic rupture on plain chest radiographs without the performance of a large number of aortographically negative studies. The bedside anteroposterior "erect" view of the chest proved far more valuable than the supine view in detecting true-negative studies. Despite significant reader variability in the interpretation of the various radiographic signs, in general the analysis confirmed the role of chest radiography in this clinical situation, but suggests that its most beneficial use is in excluding the diagnosis and eliminating unwarranted aortography rather than in predicting aortic rupture. 相似文献
972.
Balloon dilatation of excised aortic coarctations 总被引:2,自引:0,他引:2
Lock JE; Castaneda-Zuniga WR; Bass JL; Foker JE; Amplatz K; Anderson RW 《Radiology》1982,143(3):689-691
Seven children 1-6 years of age underwent aortic resection and re-anastomosis for coarctation of the thoracic aorta. The excised segments were 1-2 cm long and were dilated in vitro with a Grüntzig balloon catheter less than two hours after resection. A pressure of 4-8 atmospheres was used, and the inflated diameter of the balloon was twice the luminal diameter of the undilated coarctation. The diameter of each specimen was increased by an average of 85%, largely because of an increase in the external diameter of the coarctation. However, extremely high pressures were required for successful dilatation, producing transmedial tears in the "normal" aorta distal to the coarctation in three specimens. These results indicate that although balloon dilatation appears feasible as palliation for aortic coarctation, further studies of its safety are necessary before instituting clinical trials. 相似文献
973.
Martínez Ramírez A Gray Santacruz C García De Alba JE Fraustro SR 《Cadernos de saúde pública / Ministério da Saúde, Funda??o Oswaldo Cruz, Escola Nacional de Saúde Pública》1996,12(4):483-487
This study was carried out at the General Hospital of Zone N masculine 14 of the IMSS in Jalisco, Mexico, with the goal of designing standardized criteria to handle hospitalized diabetes patients, as a strategy for quality assurance, through the participation of a panel of experts in internal medicine from the hospital. Participation by the attending physician in designing criteria generates a sense of belonging in the staff and makes adherence and application easier. The suggested criteria are subject to further improvement and are not intended for universal application, but to the extent that they have been useful in patient care they have far surpassed the authors' expectations when the goals of this research were originally established. 相似文献
974.
Shibata MA; Jorcyk CL; Devor DE; Yoshidome K; Rulong S; Resau J; Roche N; Roberts AB; Ward JM; Green JE 《Carcinogenesis》1998,19(1):195-205
We demonstrate that targeted expression of SV40 large T antigen (TAg) to
the urethral (periurethral) and bulbourethral gland epithelium leads to
adenocarcinoma formation in these tissues after 7 months of age, which are
extremely rare sites for spontaneous tumor formation in humans. The
development of proliferative lesions in the urethral gland predictably
follows a temporal course of progression with approximately one third of
male animals developing urethral tumors by 1 year of age. Tumor progression
in these organs correlates to the level of TAg and p53 expression.
Immunoprecipitation confirmed that SV40 TAg protein was bound to p53 and Rb
p110 in vivo. Expression of transforming growth factor beta (TGFbetas) was
evaluated during tumor progression of urethral gland carcinomas. Elevations
of intracellular and extracellular TGFbeta1 and extracellular TGFbeta3 were
found in preneoplastic and neoplastic lesions, suggesting that increased
TGFbetas may augment tumor growth. c-Met expression showed a tendency for
increased expression in the urethral gland carcinomas. We speculate that
the directed expression of SV40 TAg by the hormone responsive C3(1) gene
and subsequent tumor formation in these organs is influenced by androgens,
since these tissues and carcinomas express androgen receptor (AR) and arise
only in male transgenic mice. Several cell lines established from the
urethral carcinomas were also shown to express AR, but are not androgen
dependent in culture. To our knowledge, this is the first transgenic animal
model for urethral and bulbourethral carcinomas. This transgenic mouse
model and the cell lines derived from it may provide a unique opportunity
for dissecting molecular mechanisms involved in the tumorigenesis of these
organs which otherwise rarely develop cancer.
相似文献
975.
The cases are reported of 13 children seen over a 22 month period who presented with a variety of acute neurological illnesses associated with Mycoplasma pneumoniae infection. Although presentation with a decreased level of consciousness or seizures was common, psychosis, hemiparesis, cranial nerve palsies, and Guillain-Barré syndrome were also seen. In contrast with published reports, only one child had an associated chest infection. Although some children have been left with residual disability, most have made a complete recovery. In this recent experience, M pneumoniae is a not rare cause of neurological illness in childhood and may present in unusual ways. 相似文献
976.
A 3 year old child with known pulmonary haemosiderosis suffered acute circulatory collapse secondary to raised pulmonary vascular resistance. Nitric oxide inhalation produced a profound improvement in circulatory parameters and gaseous exchange. Nitric oxide may have a therapeutic role in acute pulmonary hypertensive crisis. 相似文献
977.
TJ O'Dempsey BE Laurence TF McArdle JE Todd AC Lamont BM Greenwood 《Archives of disease in childhood》1993,68(4):492-495
A raised respiratory rate is a useful sign in the diagnosis of pneumonia in children. It was observed that children with malaria and other febrile illnesses may also present with a raised respiratory rate. To determine the extent to which increased body temperature contributes to the raised respiratory rate observed in these children the effect of change in body temperature on respiratory rate was measured in 186 sick Gambian children with a raised respiratory rate, including those with pneumonia or malaria. A temperature dependent effect on respiratory rate of 3.7 breaths per minute per degree centigrade was demonstrated for the whole study cohort, with no significant difference between children with pneumonia or malaria. Twenty three per cent of children with pneumonia whose temperature fell had a final respiratory rate below that currently recommended by the World Health Organisation for the diagnosis of pneumonia. It is concluded that respiratory rate is to some extent dependent on body temperature in children with febrile illnesses such as pneumonia and malaria, but that this does not alone account for the raised respiratory rate seen in these children. The effect of reduction in body temperature on respiratory rate does not help to distinguish children with pneumonia from those with malaria. A history of recent use of an antipyretic or other measures to control fever is important when evaluating children for possible pneumonia. 相似文献
978.
Busca A; Anasetti C; Anderson G; Appelbaum FR; Buckner CD; Doney K; Martin PJ; Petersdorf E; Sanders JE; Hansen JA 《Blood》1994,83(10):3077-3084
High-dose chemoradiotherapy followed by marrow transplantation from an HLA-matched sibling donor is curative for patients with acute leukemia. Autologous marrow transplantation has been used with success for some patients without such a sibling. Alternatively, the option of performing a transplant from an HLA-matched unrelated donor has been made possible by the recent development of large registries of HLA- typed volunteers. The purpose of this study was to compare the outcomes for patients with advanced leukemia treated by unrelated or autologous marrow transplantation. Forty-three patients with acute myeloid or lymphoid leukemia were transplanted from a closely HLA-matched unrelated donor. Results were compared with those of a disease-, disease-stage-, and age-matched cohort of 77 patients treated with autologous marrow transplantation at the same institution during the same period. Myeloid reconstitution with peripheral granulocyte counts greater than 10(9)/L was achieved in 93% of unrelated recipients and 70% of autologous recipients at a median of 24 and 36 days after transplantation, respectively (P = .0001). The cumulative proportions of patients discharged alive (79% v 77%) and times from transplant to first hospital discharge (35 v 34 days) were not different between unrelated and autologous recipients (P = .65). For patients transplanted in complete remission, relapse occurred after transplantation in 27% of the unrelated and in 55% of the autologous recipients (P = .08). For patients transplanted in relapse, the corresponding posttransplant relapse rates were 48% and 63%, respectively (P = .72). Forty percent of unrelated recipients and 28% of autologous recipients died in remission. Leukemia-free survivals were 33% for unrelated and 25% for autologous recipients transplanted in remission (P = .45), and 12% for unrelated and 5% for autologous recipients transplanted in relapse (P = .75). Unrelated donor transplants appear no less effective than autologous transplants to achieve long-term survival and may be more effective in eradicating leukemia in patients who have failed conventional chemotherapy. Further studies are warranted to assess the relative effectiveness of unrelated and autologous transplantation performed earlier in the course of the disease. 相似文献
979.
Pathogenesis of B cell lymphoma in a patient with AIDS 总被引:5,自引:0,他引:5
Groopman JE; Sullivan JL; Mulder C; Ginsburg D; Orkin SH; O'Hara CJ; Falchuk K; Wong-Staal F; Gallo RC 《Blood》1986,67(3):612-615
Lymphoma occurs at increased frequency in patients with the acquired immunodeficiency syndrome (AIDS). We studied, using serologic and molecular techniques, one such lymphoma for (a) evidence of infection with human T lymphotropic virus, type III (HTLV-III), and Epstein-Barr virus (EBV), (b) monoclonal rearrangement of immunoglobulin and T cell receptor genes, and (c) rearrangement of the c-myc oncogene. Immunoglobulin and T cell receptor gene studies demonstrated that the tumor was of monoclonal B cell origin. Similar to cases of Burkitt's lymphoma unrelated to AIDS, there were DNA sequences in the lymphoma that hybridized to EBV-specific probes and demonstrated evidence of c- myc rearrangement. HTLV-III sequences were not detected in the malignant B cells. The pathogenesis of some B cell neoplasms in patients with the syndrome may involve transformation by EBV and deregulation of oncogene expression without direct infection of the malignant B cells by HTLV-III. 相似文献
980.