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Stephanie O. Ibemere Charity I. Oyedeji Liliana Preiss Laura E. Van Althuis Jane S. Hankins Melissa Azul Ebony N. Burns Jeffrey Glassberg Ward Hagar Faiz Hussain Allison King Cathy Melvin John Myers Angela Snyder Nirmish Shah Paula Tanabe Sickle Cell Disease Implementation Consortium 《British journal of haematology》2023,200(5):633-642
Individuals with sickle cell disease (SCD) have historically been considered underweight. Despite increasing body mass index (BMI) in the general population, the prevalence of overweight and obese status remains unclear in the adult SCD population. Our primary aim was to determine the prevalence of overweight and obese status and to identify associations between BMI, demographic, and clinical characteristics. We conducted an analysis of abstracted electronic health record data and patient-reported outcomes from the Sickle Cell Disease Implementation Consortium registry; individuals aged 20–45 years were included. The median (interquartile range) BMI for the 1664 adults in this analysis was 23.9 (21.1–28) kg/m2. In this cohort, 42.9% had a BMI of >25 kg/m2 (Centers for Disease Control and Prevention definition of overweight/obese). In multivariable analysis, higher odds of being overweight or obese were associated with female gender, older age, college education, private insurance, and hypertension diagnosis. Higher odds of a BMI of >25 kg/m2 were observed in individuals with HbSC or HbSβ+ thalassaemia regardless of hydroxycarbamide (hydroxyurea) exposure (odds ratio [OR] 3.4, p < 0.0001) and HbSS or HbSβ0 thalassaemia exposed to hydroxycarbamide (OR 1.6, p = 0.0003) compared to those with HbSS or HbSβ0 thalassaemia with no hydroxycarbamide exposure. These data highlight the importance of early identification, prevention, and intervention for increasing BMI to reduce obesity-related complications that may impact SCD-related complications. 相似文献
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Kassem Bourgi Cathy A Jenkins Peter F Rebeiro Bryan E. Shepherd Frank Palella Richard D Moore Keri N Althoff John Gill Charles S Rabkin Stephen J Gange Michael A Horberg Joseph Margolick Jun Li Cherise Wong Amanda Willig Viviane D Lima Heidi Crane Jennifer Thorne Michael Silverberg Gregory Kirk William C Mathews Timothy R Sterling Jordan Lake John R Koethe for the North American AIDS Cohort Collaboration on Research Design 《Journal of the International AIDS Society》2020,23(4)
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Luo CC 《Archives of physical medicine and rehabilitation》2005,86(2):332-334
Luo CC. Spinal cord compression secondary to metastatic non-Hodgkin’s lymphoma: a case report.Non-Hodgkin’s lymphoma spine metastasis is a rare entity. A woman in her mid fifties with history of non-Hodgkin’s lymphoma was admitted to the hospital with bilateral leg weakness, anesthesia, and incontinence. Magnetic resonance imaging of the spine showed diffuse metastatic disease involving the cervical, thoracic, lumbar, and sacral spine. She was treated with radiation therapy and high doses of corticosteroids. When discharged to home, she could ambulate with a rolling walker independently, was capable of self-catheterization, and could insert suppositories for a bladder and bowel program. 相似文献