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991.
992.
Taylor Endrigo Toscano Olivo Edson Carvalho de Melo Cristiane Rocha Carlos Magno C.B. Fortaleza 《Burns : journal of the International Society for Burn Injuries》2009
Methicillin-resistant Staphylococcus aureus (MRSA) is an important agent of colonization and infection in burn units. In order to identify risk factors for MRSA acquisition in a Brazilian burn unit, we performed two retrospective studies. In the first (“cohort” study), 175 patients who were not colonized with MRSA on admission were followed to assess risk factors for MRSA acquisition. In the second (“case–case–control” study), 143 individuals from the previous study who were negative for both MRSA and Methicillin-susceptible S. aureus (MSSA) on admission were followed. Case–control studies were performed to investigate risk factors for MRSA and MSSA acquisition. MRSA and MSSA were recovered from 75 and 23 patients, respectively. In the “cohort” study, only the number of wound excisions (Odds Ratio [OR] = 1.55, 95% Confidence Interval [CI] = 1.21–1.98, P = 0.001) was associated with MRSA acquisition. In the “case–case–control” study, burns involving head (OR = 3.43, 95%CI = 1.50–7.81, P = 0.003) and the number of wound excisions (OR = 1.83, 95%CI = 1.27–2.63, P = 0.001) were significant risk factors for MRSA. Burns involving perineum were negatively associated with MSSA acquisition (OR = 0.16, 95%CI = 0.03–0.75, P = 0.02). In conclusion, the acquisition of MRSA was related to the site of the burn and to the surgical manipulation of tissues, but not to the use of antimicrobials. 相似文献
993.
994.
de Godoy Peres FF Aigotti Haberbeck Brandão A Rodarte Carvalho Y Dória Filho U Plapler H 《Lasers in medical science》2009,24(3):375-385
Therapeutic approaches to chronic actinic cheilitis focus on the removal or destruction of diseased epithelium. The CO2 laser has become an important therapeutic alternative, achieving clinical resolution in around 90% of patients. Although
many laser physical parameters have been reported, some are known for their low potential for scar induction without compromising
the success of the results. The aim of this clinicohistological study was to compare the therapeutic responses to two low-morbidity
protocols involving a single laser pass. A total of 40 patients with chronic multicentric and microscopically proven disease
were randomly submitted to two conservative CO2 laser protocols using a bilateral comparative model. The degree of histological atypia of the epithelium was determined in
26 patients both pre- and postoperatively for both protocols. Other histological phenomena were assessed in addition to this
central analysis parameter. Clinical recurrence occurred in 12.5% of patients for each protocol, together with a significant
reduction in the degree of epithelial atypia (p < 0.001), which was occasionally complete. However, no difference was found between the protocols (p > 0.05). Using these morphological parameters it was not possible to determine whether postoperative epithelial atypias in
part of the sample were reactive or residual in nature. A few patients may show minor postoperative lesions. Due to their
potential to achieve clinical and importantly microscopic resolution, the studied protocols may be used for mild through moderate
dysplastic epithelium and clinically diffuse disease.
相似文献
Flávio Francisco de Godoy PeresEmail: |
995.
Nilzete Bresolin Carlos Silva Ana Halllal Julio Toporovski Vera Fernandes Jose Góes Francisca Ligia Carvalho 《Pediatric nephrology (Berlin, Germany)》2009,24(3):537-544
To define factors of prognostic importance for critically ill infants and children with acute kidney injury (AKI), we have studied 110 children, ages from 1 month to 180 months, admitted between March 1, 2002 and September 30, 2004 to the intensive care unit of Joana de Gusmão Children’s Hospital. These patients represent 8% of all intensive care unit admissions during the entire study period. The diagnosis at admission was primary renal parenchyma disease (eight patients, 7.2%) and secondary renal disease (102 patients, 92.8%). Thirty-seven patients (33.6%) died, all of whom had secondary renal insufficiency; six patients (5.4%) died as a result of septic shock, and 31 (28.2%) patients died from multiple organ failure (MOF). The variables were analyzed using Fisher’s exact test for qualitative variables and Student’s t-test for quantitative variables. Stratified analysis was performed to assess the relative importance of variables using the Mantel–Haenszel technique. Among the variables analyzed, the following were found to be significantly related to mortality: anuria, oliguria, arterial hypotension, need for pressor drugs, need for mechanical ventilation, need for dialysis, the association with MOF, and high values of lactic acid. 相似文献
996.
Hedy Vkony Kerstin Rser Thomas Lning Bauke Ylstra Gerrit A. Meijer Wessel N. van Wieringen Mark A. van de Wiel Beatriz Carvalho Klaas Kok C. Ren Leemans Isac van der Waal Elisabeth Bloemena 《Genes, chromosomes & cancer》2009,48(2):202-212
Salivary gland myoepithelial tumors are relatively uncommon tumors with an unpredictable clinical course. More knowledge about their genetic profiles is necessary to identify novel predictors of disease. In this study, we subjected 27 primary tumors (15 myoepitheliomas and 12 myoepithelial carcinomas) to genome‐wide microarray‐based comparative genomic hybridization (array CGH). We set out to delineate known chromosomal aberrations in more detail and to unravel chromosomal differences between benign myoepitheliomas and myoepithelial carcinomas. Patterns of DNA copy number aberrations were analyzed by unsupervised hierarchical cluster analysis. Both benign and malignant tumors revealed a limited amount of chromosomal alterations (median of 5 and 7.5, respectively). In both tumor groups, high frequency gains (≥20%) were found mainly at loci of growth factors and growth factor receptors (e.g., PDGF, FGF(R)s, and EGFR). In myoepitheliomas, high frequency losses (≥20%) were detected at regions of proto‐cadherins. Cluster analysis of the array CGH data identified three clusters. Differential copy numbers on chromosome arm 8q and chromosome 17 set the clusters apart. Cluster 1 contained a mixture of the two phenotypes (n = 10), cluster 2 included mostly benign tumors (n = 10), and cluster 3 only contained carcinomas (n = 7). Supervised analysis between malignant and benign tumors revealed a 36 Mbp‐region at 8q being more frequently gained in malignant tumors (P = 0.007, FDR = 0.05). This is the first study investigating genomic differences between benign and malignant myoepithelial tumors of the salivary glands at a genomic level. Both unsupervised and supervised analysis of the genomic profiles revealed chromosome arm 8q to be involved in the malignant phenotype of salivary gland myoepitheliomas. © 2008 Wiley‐Liss, Inc. 相似文献
997.
998.
Flávia Aparecida de Oliveira Eliza Carla Barroso Duarte Cláudia Teixeira Taveira Aline Abreu Máximo Érica Carvalho de Aquino Rita de Cássia Alencar Eneida Franco Vencio 《Head and neck pathology》2009,3(4):271-275
Salivary gland tumors consist of a group of heterogeneous lesions with complex clinicopathological characteristics and distinct
biological behaviors. Worldwide series show a contrast in the relative incidence of salivary gland tumors, with some discrepancies
in clinicopathological data. The main aim of this study was to describe demographic characteristics of 599 cases in a population
from Central Brazil over a 10-year period and compare these with other epidemiological studies. Benign tumors represented
78.3% of the cases. Women were the most affected (61%) and the male:female ratio was 1:1.6. Parotid gland tumors were the
most frequent (68.5% of cases) and patient age ranged from 1 to 88 years-old (median of 45 years old). The most frequent tumors
were pleomorphic adenomas (68.4%) and benign tumors were significantly more frequent in the parotid (75.9%), while malignant
tumors were more frequent in the minor salivary glands (40%) (P < 0.05). In conclusion, women and the parotid gland were the most affected and pleomorphic adenoma was the most frequent
lesion, followed by adenoid cystic carcinoma and Warthin’s tumor. 相似文献
999.
H. Tedesco-Silva M.I. Lorber C.E. Foster H.W. Sollinger R. Mendez D.B. Carvalho R. Shapiro P.R. Rajagopalan H. Mayer J. Slade B.D. Kahan for the FTYA clinical study group 《Clinical transplantation》2009,23(5):589-599
Abstract: This exploratory, multicenter, open-label study evaluated the efficacy and safety of FTY720, as a part of an immunosuppressive regimen, in combination with everolimus and steroids in de novo renal transplant recipients at increased risk of delayed graft function (DGF). Patients received FTY720 (5 mg) and everolimus (4 mg) 2–12 h pre-transplantation, followed by 2.5 mg/d FTY720 and concentration-controlled everolimus (4–8 ng/mL) post-transplant for 12 months. Induction therapy was prohibited. After enrollment of 56 of the planned 200 patients between 2000 and 2002, the recruitment was terminated. The primary endpoint, rate of graft loss, or death at three months was 15.4% and the biopsy-confirmed acute rejection was 42.3%. Death or graft loss at 12 months in the DGF and non-DGF arms was 36.0% and 25.9%, respectively. The mean estimated creatinine clearance at three months was 63 and 55 mL/min in the non-DGF and DGF groups, respectively, while at 12 months it was 56 mL/min in both the groups. Although there was no comparator arm, the results from this exploratory study (compared with data from other phases II and III trials) indicated no apparent benefits of FTY720-based regimens for prevention of acute rejection and preservation of renal function in renal transplant recipients at high risk of DGF. 相似文献
1000.
Filipe Abdalla dos Reis Ana Carulina Guimarães Belchior Paulo de Tarso Camillo de Carvalho Baldomero Antônio Kato da Silva Daniel Martins Pereira Iandara Schettert Silva Renata Amadei Nicolau 《Lasers in medical science》2009,24(5):741-747
The aim of this study was to analyze the influence of aluminum gallium arsenide (AlGaAs) laser (660 nm) on the myelin sheath
and functional recovery of the sciatic nerve in rats. The sciatic nerves of 12 Wistar rats were subjected to injury through
neurotmesis and epineural anastomosis, and the animals were divided into two groups: group 1 was the control and group 2,
underwent low-level laser therapy (LLLT). After the injury, AlGaAs laser at 660 nm, 4 J/cm2, 26.3 mW and beam area of 0.63 cm2 was administered to three equidistant points on the injury for 20 consecutive days. In the control group the mean area of
the myelin impairment was 0.51 (± 0.11) on day 21 after the operation, whereas this value was 1.31 (± 0.22) in the LLLT group.
Student’s t-test revealed a P value = 0.0229 for the mean area values of the myelin sheath between the LLLT and control groups. Comparison of the sciatic
functional index (SFI) showed that there was no significant difference between the pre-lesion value in the laser therapy group
and the control group. The use of AlGaAs laser (660 nm) provided significant changes to the morphometrically assessed area
of the myelin sheath, but it did not culminate in positive results for functional recovery in the sciatic nerve of the rats
after injury through neurotmesis. 相似文献