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991.
The purpose of this roentgen stereophotogrammetric analysis (RSA) study was to evaluate the initial stability of cemented and cementless tibial components in vitro. Twenty tibia specimens were matched into two groups. In the first group, the tibial trays were cemented superficially and in the second group cementless fixation with stem and screws was performed. An axial load of 2000 N for 1000 and 10,000 cycles was applied onto the specimens and RSA was performed. The experimental results after 1000 cycles showed a higher migration with significant differences for the parameters maximum lift off (p = 0.011) and maximum total point motion (p = 0.002) in the cementless group. After 10,000 cycles, the migration in the cementless group increased significantly for maximum lift off (p = 0.043), maximum subsidence (p = 0.045) and maximum total point motion (p = 0.013). The higher migration rates in the cementless group demonstrate a lower initial mechanical stability of cementless tibial components which can cause an early component loosening. 相似文献
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Karyopherin Alpha 2 Is an Adverse Prognostic Factor in Clear-Cell and Papillary Renal-Cell Carcinoma
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Peter K.-F. Chiu Chi-Fai Ng Axel Semjonow Yao Zhu Sébastien Vincendeau Alain Houlgatte Massimo Lazzeri Giorgio Guazzoni Carsten Stephan Alexander Haese Ilse Bruijne Jeremy Yuen-Chun Teoh Chi Ho Leung Paola Casale Chih Hung Chiang Lincoln Guan-Lim Tan Edmund Chiong Chao Yuan Huang Monique J. Roobol 《European urology》2019,75(4):558-561
Asians have a lower incidence of prostate cancer (PC). We compared the performance of the Prostate Health Index (PHI) for 2488 men in different ethnic groups (1688 Asian and 800 European men from 9 sites) with PSA 2–20 ng/ml and PHI test and transrectal ultrasound-guided biopsy results available. Of these, 1652 men had PSA 2–10 ng/ml and a normal digital rectal examination and underwent initial biopsy. The proportions of PC (Gleason ≥6) and higher-grade PC (HGPC, Gleason ≥7) across different PHI ranges were compared. The performance of PSA and PHI was compared using the area under the receiver operating characteristic curve (AUC) and decision curve analyses (DCA). Among Asian men, HGPC would be diagnosed in 1.0%, 1.9%, 13%, and 30% of men using PHI thresholds of <25, 25–35, 35–55, and >55, respectively. At 90% sensitivity for HGPC (PHI >30), 56% of biopsies and 33% of Gleason 6 PC diagnoses could have been avoided. Among European men, HGPC would be diagnosed in 4.1%, 4.3%, 30%, and 34% of men using PHI thresholds of <25, 25–35, 35–55, and >55, respectively. At 90% sensitivity for HGPC (PHI >40), 40% of biopsies and 31% of Gleason 6 PC diagnoses could have been avoided. AUC and DCA confirmed the benefit of PHI over PSA. The benefit of PHI was also seen at repeat biopsy (n = 397) and for PSA 10–20 ng/ml (n = 439). PHI is effective in cancer risk stratification for both European and Asian men. However, population-specific PHI reference ranges should be used.
Patient summary
The Prostate Health Index (PHI) blood test helps to identify individuals at higher risk of prostate cancer among Asian and European men, and could significantly reduce unnecessary biopsies and overdiagnosis of prostate cancer. Different PHI reference ranges should be used for different ethnic groups. 相似文献1000.