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61.
Detection and incidence of cryptic Y chromosome sequences in Turner syndrome patients 总被引:1,自引:0,他引:1
Philippos C Patsalis Carolina Sismani Michael I Hadjimarcou Sophia Kitsiou-Tzeli Aspasia Tzezou Charalambos G Hadjiathanasiou Voula Velissariou Evangelia Lymberatou Nicholas K Moschonas Nicos Skordis 《Clinical genetics》1998,53(4):249-257
The presence of Y chromosome sequences in Turner syndrome (TS) patients may predispose them to gonadoblastoma formation with an estimated risk of 15–25%. The aim of this study was to determine the presence and the incidence of cryptic Y chromosome material in the genome of TS patients. The methodology involved a combination of polymerase chain reaction (PCR) and nested PCR followed by Southern blot analysis of three genes—the sex determining region Y (SRY), testis specific protein Y encoded (TSPY) and RNA binding motif protein (RBM) (previously designated as YRRM) and nine additional STSs spanning all seven intervals of the Y chromosome. The methodology has a high sensitivity as it detects one 46, XY cell among 105 46, XX cells. Reliability was ensured by taking several precautions to avoid false positive results. We report the results of screening 50 TS patients and the identification of cryptic Y chromosome material in 12 (24%) of them. Karyotypes were divided in four groups: 5 (23.8%) patients out of the 21 TS patients which have the 45, X karyotype (group A) also have cryptic Y sequences; none (0%) of the 7 patients who have karyotypes with anomalies on one of the X chromosomes have Y mosaicism (group B); 1 (6.3%) of the 16 patients with a mosaic karyotype have Y material (group C); and 6 (100%) out of 6 patients with a supernumerary marker chromosome (SMC) have Y chromosome sequences (group D). Nine of the 12 patients positive for cryptic Y material were recalled for a repeat study. Following new DNA extraction, molecular analysis was repeated and, in conjunction with fluorescent in situ hybridization (FISH) analysis using the Y centromeric specific probe Yc-2, confirmed the initial positive DNA findings. This study used a reliable and sensitive methodology to identify the presence of Y chromosome material in TS patients thus providing not only a better estimate of a patient's risk in developing either gonadoblastoma or another form of gonadal tumor but also the overall incidence of cryptic Y mosaicism. 相似文献
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63.
J J Vitale 《Clinical orthopaedics and related research》1985,(198):158-168
Strenuous or vigorous exercise does not appear to significantly alter the requirements for any specific nutrient except calories. The major nutritional problem in sports medicine, particularly among the young, will be one of meeting caloric requirements from a variety of foods. As high- or low-energy requirements are met, so will requirements for all other essential nutrients. We should all heed the words of Sir Robert Hutchison (1871-1960), as perhaps the Food and Nutrition Board did. He wrote in the New Castle Medical Journal, vol. 12, 1932, "One swears by whole meal bread, one by sour milk; vegetarianism is the only road to the salvation of some, other insist not only in vegetables alone, but on eating those raw. At one time the only thing that matters is calories; at another time they are crazy about vitamins or about roughage. Scientific truth may be put quite briefly; eat moderately, having an ordinary mixed diet and don't worry." Robert Charles Benchley (1889-1945), an American humorist, critic, and actor, was known to say that when the thought of exercise came upon him, he would lie down until the thought passed over. Clement Richard Attlee (1883-1967), prime minister of the United Kingdom from 1945 to 1951, said he owed his long life to resisting all forms of exercise. 相似文献
64.
Extremity reconstruction using the "fillet of sole" flap 总被引:1,自引:0,他引:1
Foot skin can be used in traumatic nonreplantable leg amputations as an immediate neurovascular free flap for proximal stump reconstruction. The thick, glabrous skin on the sole of the foot provides durable, sensate coverage. The flap is large, avoids a secondary donor site, and can survive on either the dorsalis pedis or posterior tibial artery if one preserves the connecting deep plantar branch of the dorsalis pedis artery. Two cases of immediate stump reconstruction using the "fillet of sole" flap are presented. 相似文献
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Yasmin Amaral Leila Silva Fernanda Soares Daniele Marano Sylvia Nehab Andrea Abranches Ana Carolina Costa Maria Elisabeth Moreira 《Nutrients》2021,13(5)
Background: To evaluate the potential factors associated with the nutritional composition of human milk of puerperal women. Methods: cross-sectional study, conducted between March 2016 and August 2017, with 107 women, selected in a Tertiary Health Care Tertiary Health Facility of the Unified Health System (SUS) in the Municipality of Rio de Janeiro. Data were collected two months after delivery. The dependent variable of the study was the nutritional composition of human milk. We divided the independent variables into hierarchical levels: distal (age, schooling, parity and pregestational nutritional status), intermediate (number of prenatal visits and gestational weight gain) and proximal (alcohol consumption, smoking, diabetes mellitus and hypertension). For data analysis, we applied the multiple linear regression, centered on the hierarchical model. Only the variables associated with the nutritional composition of breast milk remained in the final model at a 5% level of significance. Results: The nutritional composition of human milk yielded by women with pregestational overweight, smokers and hypertensive had higher amounts of lipids and energy. Conversely, women with gestational weight gain below the recommended had lower amounts of these components. Conclusion: The evaluation of factors associated with the nutritional composition of human milk is extremely important to assist post-partum care practices. In this study, we observed that lipid and energy contents were associated to pregestational nutritional status, gestational weight gain, smoking and hypertension. 相似文献
67.
Monica Ruotolo Mario Gagliardi Carolina Ciacci Fabiana Zingone Corina de Santis Ciacci Antonella Santonicola Giovanna DArcangelo Monica Siniscalchi 《Nutrients》2021,13(6)
Background: Coronavirus disease 2019 (COVID-19) causes not only severe illness but also detrimental effects associated with the lockdown measures. The present study aimed to evaluate reported lifestyle changes in a cohort of adults in Italy, including physical exercise, food choices, and psychological wellbeing, after two months of lockdown. Methods: A web survey on social media (Facebook and LinkedIn) of 32 multiple-choice questions aiming to evaluate the impact of the national COVID-19 lockdown in a sample of Italian adults. Results: We received 1378 complete responses (women 68.3%, mean age 39.5 ± 12.5 years). The percentage of participants reporting regular exercise decreased during lockdown (52 vs. 56.5%). The vast majority of people continued to consume the three traditional meals per day, but the consumption of meat, fish, and eggs significantly decreased. Women reported more frequent anxiety, sadness, fear, and feelings of insecurity than men. The factors predicting the worst outcome during the lockdown were being a woman, low education and income, gastrointestinal diseases. Conclusion: The lockdown has had a limited impact on food choices and physical exercise in Italian adults of our series, since most of them made an effort to improve their lifestyle. However, women with gastrointestinal diseases reported more frequent negative feelings and poor adaptation to the lockdown. 相似文献
68.
69.
Helen Pineo Camilla Audia Daniel Black Matthew French Emily Gemmell Gina S. Lovasi James Milner Felipe Montes Yanlin Niu Carolina Prez-Ferrer Jos Siri Ruzka R. Taruc 《Journal of urban health》2021,98(3):442
Anthropogenic environmental change will heavily impact cities, yet associated health risks will depend significantly on decisions made by urban leaders across a wide range of non-health sectors, including transport, energy, housing, basic urban services, and others. A subset of planetary health researchers focus on understanding the urban health impacts of global environmental change, and how these vary globally and within cities. Such researchers increasingly adopt collaborative transdisciplinary approaches to engage policy-makers, private citizens, and other actors in identifying and evaluating potential policy solutions that will reduce environmental impacts in ways that simultaneously promote health, equity, and/or local economies—in other words, maximising ‘co-benefits’. This report presents observations from a participatory workshop focused on challenges and opportunities for urban planetary health research. The workshop, held at the 16th International Conference on Urban Health (ICUH) in Xiamen, China, in November 2019, brought together 49 participants and covered topics related to collaboration, data, and research impact. It featured research projects funded by the Wellcome Trust’s Our Planet Our Health (OPOH) programme. This report aims to concisely summarise and disseminate participants’ collective contributions to current methodological practice in urban planetary health research. 相似文献
70.
Close Carolina Elek Elvira Roberts Cheryl A. Dunlap Laura J. Graham Phillip W. Scaglione Nichole M. Palen Lori-Ann Clarke Thomas 《Prevention science》2021,22(8):1071-1085
Prevention Science - This prospective cost analysis addresses a gap in the prevention literature by providing estimates of the typical real-world costs to implement community interventions focused... 相似文献