全文获取类型
收费全文 | 1899篇 |
免费 | 112篇 |
国内免费 | 17篇 |
专业分类
耳鼻咽喉 | 8篇 |
儿科学 | 33篇 |
妇产科学 | 52篇 |
基础医学 | 276篇 |
口腔科学 | 11篇 |
临床医学 | 202篇 |
内科学 | 419篇 |
皮肤病学 | 52篇 |
神经病学 | 238篇 |
特种医学 | 51篇 |
外科学 | 177篇 |
综合类 | 6篇 |
预防医学 | 123篇 |
眼科学 | 20篇 |
药学 | 165篇 |
中国医学 | 5篇 |
肿瘤学 | 190篇 |
出版年
2024年 | 3篇 |
2023年 | 16篇 |
2022年 | 50篇 |
2021年 | 57篇 |
2020年 | 28篇 |
2019年 | 33篇 |
2018年 | 58篇 |
2017年 | 46篇 |
2016年 | 52篇 |
2015年 | 62篇 |
2014年 | 75篇 |
2013年 | 97篇 |
2012年 | 160篇 |
2011年 | 153篇 |
2010年 | 81篇 |
2009年 | 81篇 |
2008年 | 141篇 |
2007年 | 139篇 |
2006年 | 125篇 |
2005年 | 107篇 |
2004年 | 121篇 |
2003年 | 103篇 |
2002年 | 84篇 |
2001年 | 17篇 |
2000年 | 10篇 |
1999年 | 12篇 |
1998年 | 10篇 |
1997年 | 11篇 |
1996年 | 10篇 |
1995年 | 9篇 |
1994年 | 6篇 |
1993年 | 6篇 |
1992年 | 6篇 |
1990年 | 4篇 |
1989年 | 4篇 |
1988年 | 3篇 |
1986年 | 4篇 |
1985年 | 5篇 |
1984年 | 5篇 |
1983年 | 3篇 |
1982年 | 3篇 |
1981年 | 3篇 |
1980年 | 3篇 |
1975年 | 1篇 |
1974年 | 2篇 |
1972年 | 1篇 |
1968年 | 1篇 |
1961年 | 1篇 |
1945年 | 9篇 |
1943年 | 4篇 |
排序方式: 共有2028条查询结果,搜索用时 15 毫秒
41.
42.
Purpose
Morphine ARER is a novel oral, abuse-deterrent, extended-release (ER) formulation of morphine sulfate with physical and chemical properties that deter misuse and abuse by nonoral routes of administration. Here we evaluate the relative bioavailability of morphine ARER and extended-release morphine.Methods
This single-dose, 2-treatment, 2-period, 2-sequence, randomized crossover study in healthy adult subjects compared the relative bioavailability of morphine ARER 100 mg to that of ER morphine 100 mg in the fasted condition. At 12 and 1.5 hours before dosing and 12 hours after dosing, all subjects received a 50-mg oral naltrexone tablet to minimize opioid-related side effects. Pharmacokinetic parameters including the AUC0–t, AUC0–∞, and Cmax of morphine and its metabolite morphine-6-glucuronide (M6G) were determined at various times up to 48 hours postdose. The bioequivalence of morphine ARER and ER morphine was determined using an ANOVA of the least-squares mean values of morphine and M6G bioavailability.Findings
Forty-nine subjects completed the study. Both morphine ARER and ER morphine exhibited peak plasma morphine and M6G concentrations of ~30 ng/mL and ~200 ng/mL, respectively, at 3 hours postdose. The 90% CIs of the ln-transformed values of morphine AUC0–t, AUC0–∞, and Cmax were within the 80% to 125% range for bioequivalence. M6G values also indicated bioequivalence of morphine ARER and ER morphine. The most common adverse events were nausea and somnolence.Implications
These data show that, in these subjects, morphine ARER was bioequivalent to ER morphine, a treatment for pain with well-established efficacy and safety profiles. 相似文献43.
44.
45.
46.
Aikaterini Nanou Chrisavgi Toumpeki Pavlos Fanis Nicoletta Bianchi Lucia Carmela Cosenza Cristina Zuccato George Sentis Giorgos Giagkas Coralea Stephanou Marios Phylactides Soteroula Christou Michalis Hadjigavriel Maria Sitarou Carsten W. Lederer Roberto Gambari Marina Kleanthous Eleni Katsantoni 《Haematologica》2021,106(4):1207
47.
Conti Giovanni Galletta Francesca Carucci Nicolina Stefania La Mazza Antonella Mollica Salvatore Antonio Alibrandi Angela Visalli Carmela 《Clinical rheumatology》2021,40(9):3723-3727
Clinical Rheumatology - The aim of this study is to evaluate a possible negative action of lockdown, during the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, in the... 相似文献
48.
Liver Involvement in Obese Children (Ultrasonography and Liver Enzyme Levels at Diagnosis and During Follow-up in an Italian Population) 总被引:26,自引:0,他引:26
Maria Carmela Saviano Francesco Brunetti Armido Rubino Adriana Franzese Pietro Vajro Alessandro Argenziano Alessandro Puzziello Maria Pina Iannucci 《Digestive diseases and sciences》1997,42(7):1428-1432
Our aim was to evaluate incidence and riskfactors of liver involvement in obese Italian childrenas assessed by both ultrasonographic and biochemicalparameters. In seventy-five consecutive obese children (age 9.5 ± 2.9 years, males/females41/34), serum levels of enzymes and ultrasonography ofthe liver were evaluated. Tests were repeated one,three, and six months after starting a moderatehypocaloric diet and an exercise program. Three obese childrenwho were found to have chronic viral hepatitis wereexcluded from the study. Thirty-eight of 72 (53%) obesechildren had an ultrasonographic image of bright liver consistent with liver steatosis. Thelatter was severe in nine children, moderate in 16, andmild in 13. Eighteen obese children (25%) had elevatedtransaminase levels. Bright liver andhypertransaminasemia were not due to any of the most common causesof liver disease. Both were rapidly responsive to lossof weight, confirming that liver involvement wassecondary to obesity and that steatosis orsteatohepatitis rather than fibrosis were involved. Obesityduration not more than three years (odds ratio = 4.77),a higher degree of obesity (odds ratio = 2.09), andhypertransaminasemia (odds ratio = 2.15) appeared asimportant predictive factors of liver involvement atultrasonography. Incidence of liver involvement assessedby means of ultrasonography is significantly higher thanthat revealed by measurement of serum liver enzymes. A short duration of obesity emerged as apotentially new risk factor of liver involvement in thepediatric obese population and needs to be confirmed infuture studies. 相似文献
49.
p.Leu636Pro mutation is associated with cystic fibrosis transmembrane conductance regulator‐related disorders (congenital bilateral absence of vas deferens) 下载免费PDF全文