全文获取类型
收费全文 | 632篇 |
免费 | 67篇 |
国内免费 | 9篇 |
专业分类
耳鼻咽喉 | 1篇 |
儿科学 | 39篇 |
妇产科学 | 10篇 |
基础医学 | 52篇 |
口腔科学 | 21篇 |
临床医学 | 120篇 |
内科学 | 151篇 |
皮肤病学 | 40篇 |
神经病学 | 15篇 |
特种医学 | 101篇 |
外科学 | 65篇 |
综合类 | 12篇 |
预防医学 | 22篇 |
眼科学 | 3篇 |
药学 | 12篇 |
肿瘤学 | 44篇 |
出版年
2023年 | 8篇 |
2021年 | 6篇 |
2020年 | 5篇 |
2019年 | 8篇 |
2018年 | 15篇 |
2017年 | 15篇 |
2016年 | 24篇 |
2015年 | 18篇 |
2014年 | 31篇 |
2013年 | 29篇 |
2012年 | 13篇 |
2011年 | 17篇 |
2010年 | 30篇 |
2009年 | 50篇 |
2008年 | 15篇 |
2007年 | 13篇 |
2006年 | 21篇 |
2005年 | 17篇 |
2004年 | 14篇 |
2003年 | 12篇 |
2002年 | 7篇 |
2001年 | 8篇 |
2000年 | 3篇 |
1999年 | 11篇 |
1998年 | 33篇 |
1997年 | 34篇 |
1996年 | 36篇 |
1995年 | 26篇 |
1994年 | 24篇 |
1993年 | 29篇 |
1992年 | 6篇 |
1991年 | 6篇 |
1990年 | 7篇 |
1989年 | 15篇 |
1988年 | 12篇 |
1987年 | 19篇 |
1986年 | 11篇 |
1985年 | 8篇 |
1984年 | 7篇 |
1983年 | 5篇 |
1982年 | 3篇 |
1981年 | 9篇 |
1980年 | 5篇 |
1978年 | 3篇 |
1977年 | 3篇 |
1976年 | 5篇 |
1975年 | 2篇 |
1974年 | 2篇 |
1965年 | 1篇 |
1963年 | 2篇 |
排序方式: 共有708条查询结果,搜索用时 15 毫秒
611.
612.
MT Sanchez-Santos A Judge M Gulati TD Spector DJ Hart JL Newton NK Arden S Kluzek 《Seminars in arthritis and rheumatism》2019,48(5):791-798
Objective
It is unclear whether the association between osteoarthritis (OA) and metabolic syndrome (MetS) varies with the site of the affected joint and the presence of pain. Our aim was to describe the association between MetS and radiographic OA (ROA) affecting the knee or the hand in the presence or absence of concurrent joint pain.Methods
Cross-sectional data of 952 women, aged 45–65years from the Chingford study, a population-based longitudinal cohort of middle-aged women initiated in 1988–1989 in London (UK), was analysed. MetS was defined using the National Cholesterol Education Program Treatment Panel III criteria. Data was collected on components of MetS: waist circumference, triglycerides, high-density lipoprotein (HDL), blood pressure and blood glucose. The outcome was four knee and hand OA groups: painful ROA, ROA only, pain only and neither ROA nor pain (reference category). Multinomial logistic regression models adjusted for age and body mass index (BMI) were used to evaluate the effect of presence of MetS and its individual components on OA subgroups for knee and hand separately.Results
952 eligible women, aged 45–65years was analysed. A significant association was observed between the presence and the number of MetS with painful knee ROA when adjusted for age; however, this association disappeared when BMI was included in the model. In contrast, the presence and the number of MetS were associated with painful interphalangeal (IPJ) OA after adjusting for both age and BMI. Four out of the five MetS components, including triglycerides, HDL-c, hypertension and glucose, were associated with painful IPJ OA.Conclusions
MetS is associated with painful IPJ OA but not with knee OA once BMI is taking into consideration. Further attention to MetS and OA at different sites is needed to understand the metabolic phenotype in OA. 相似文献613.
614.
Cytosol intermediates in the transport of iron 总被引:1,自引:0,他引:1
Three 59Fe-labeled nonheme components of the cytosol were identified when rabbit reticuloyctes were incubated with 59Fe-labeled plasma under conditions in which the iron supply was not limiting. Two of these components were identified as ferritin and transferrin. The latter was characterized by gel filtration as having apparent molecular weight higher than transferrin, indicating that the transferrin may be complexed to another moiety. The third component, referred to as iron- binding protein-I (IBP-I), is as yet uncharacterized. When the reticulocytes were incubated with unlabeled plasma after pulse-labeling with 59Fe-labeled plasma, 59Fe radioactivity in these cytosol components decreased; after 15 min of chase, the 59Fe in ferritin, transferrin, and IBP-I fell to 64.6%, 26.5%, and 65.8% of the initial values, respectively. A good correlation existed between the decrease of 59Fe in these three nonheme compartments and the associated increase in 59Fe-heme. The data presented suggest that cytosol ferritin, transferrin, and IBP-I are intermediates in the transport of 59Fe from the plasma membrane to the mitochondria. 相似文献
615.
616.
Fenaux P; Le Deley MC; Castaigne S; Archimbaud E; Chomienne C; Link H; Guerci A; Duarte M; Daniel MT; Bowen D 《Blood》1993,82(11):3241-3249
We designed a multicenter randomized trial comparing chemotherapy with daunorubicin-Ara C (chemotherapy group) and all transretinoic acid (ATRA) combined to the same chemotherapy (ATRA group) in newly diagnosed APL patients aged 65 years or less. The major endpoint of the study was event-free survival (EFS) ("events" being defined as failure to achieve complete remission [CR], occurrence of relapse, or death in CR). Early termination of the trial was decided after the first interim analysis, as EFS was significantly higher in the ATRA group. At the time, 101 patients had been randomized (54 in the ATRA group and 47 in the chemotherapy group). In the ATRA group, 49 (91%) patients achieved CR, 5 (9%) had early death, and 0 had resistant leukemia, compared with 38 (81%), 4 (8%), and 5 (10%) patients, respectively, in the chemotherapy group. The difference in CR rate between the two groups was not significant. The duration of coagulopathy was significantly reduced in the ATRA group, compared with the chemotherapy group. In the ATRA group, six patients relapsed after 7 to 15.5 months. In the chemotherapy group, 12 patients relapsed after 1 to 16 months, and 2 died in CR. Kaplan-Meier EFS was estimated at 79% +/- 7% and 50% +/- 9% at 12 months, respectively, in the ATRA and the chemotherapy group (P = .001). Kaplan-Meier estimate of relapse was 19% +/- 8% and 40% +/- 12% at 12 months (P = .005). In conclusion, ATRA followed by chemotherapy increases EFS in newly diagnosed APL. These results strongly suggest that ATRA should be incorporated in the front line therapy of newly diagnosed APL. 相似文献
617.
Left ventricular myocardial function assessed by three‐dimensional speckle tracking echocardiography in Takotsubo cardiomyopathy
下载免费PDF全文
![点击此处可从《Echocardiography (Mount Kisco, N.Y.)》网站下载免费的PDF全文](/ch/ext_images/free.gif)
618.
Autism spectrum disorders (ASDs) are a heterogeneous group of neurodevelopmental disorders affecting social communication, language and behavior. The underlying cause(s) in a given individual is often elusive, with the exception of clinically recognizable genetic syndromes with readily available molecular diagnosis, such as fragile X syndrome. Clinical geneticists approach patients with ASDs by ruling out known genetic and genomic syndromes, leaving more than 80% of families without a definitive diagnosis and an uncertain risk of recurrence. Advances in microarray technology and next‐generation sequencing are revealing rare variants in genes with important roles in synapse formation, function and maintenance. This review will focus on the clinical approach to ASDs, given the current state of knowledge about their complex genetic architecture. 相似文献
619.
620.