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81.
Riyaz Bhikoo MBChB Rachael L Niederer PhD MBChB Richard Hart FRANZCO Trevor Sherwin PhD Charles NJ McGhee PhD FRCS FRANZCO 《Clinical & experimental optometry》2013,96(4):430-432
We describe the corneal microstructural changes in a patient with spheroidal degeneration using in vivo confocal microscopy. Multiple hypo‐ and hyper‐reflective spherical lesions were observed in the anterior corneal stroma and Bowman's layer ranging from 45 to 220 μm in size. The corneal epithelium, posterior stroma and endothelium were otherwise unaffected. In vivo confocal microscopy demonstrates good correlation with excised histological samples in climatic droplet keratopathy. It provides a non‐invasive technique to examine the living cornea for degenerative disease and acts as a bridge between clinical and laboratory observations. 相似文献
82.
83.
B H Bunce 《The Journal of speech and hearing disorders》1989,54(1):33-43
The effectiveness of training referential communication skills with learning-disabled (LD) students was investigated. Forty-two upper elementary-aged children were divided equally into three groups: (a) an LD training group, (b) an LD control group, and (c) a normally achieving training group. The normal group was included as a check on training procedures. All subjects were administered pretests. The measures were a listening task and two speaking tasks. The two training groups were trained in dyads on a referential communication task. Posttests were administered 1 week after training. Results indicated that on the listening task the groups were not significantly different. On both speaking measures, the LD trained group achieved significantly higher scores than did the LD control group. The LD and normally achieving training groups were not significantly different. Follow-up testing 7 months later indicated that significant differences remained between the two LD groups on one of the speaking measures. It is concluded that LD students can benefit from training on referential communication tasks. 相似文献
84.
Arwen E. Bunce Susan Griest Linda C. Howarth Phyllis Beemsterboer William Cameron Patricia A. Carney 《Journal of community health》2009,34(4):262-270
Declining student interest and scholastic abilities in the sciences are concerns for the health professions. Additionally,
the National Institutes of Health is committed to promoting more research on health behaviors among US youth, where one of
the most striking contemporary issues is obesity. This paper reports findings on the impact of a partnership between Oregon
Health and Science University (OHSU) and the Oregon Museum of Science and Industry linked to a 17-week exhibition of BodyWorlds3 and designed to inform rural underserved youth about science and health research. Self-administered survey measures included
health knowledge, attitudes, intended health behaviors, and interest in the health professions. Four hundred four surveys
(88% of participants) were included in analyses. Ninety percent or more found both the BodyWorlds (n = 404) and OHSU (n = 239) exhibits interesting. Dental care habits showed the highest level of intended behavior change (Dental = 45%, Exercise = 34%,
Eating = 30%). Overall, females and middle school students were more likely than male and high school students, respectively,
to state an intention to change exercise, eating and dental care habits. Females and high school students were more likely
to have considered a career in health or science prior to their exhibit visit and, following the exhibit, were more likely
to report that this intention had been reinforced. About 6% of those who had not previously considered a career in health
or science (n = 225) reported being more likely to do so after viewing the exhibits. In conclusion, high quality experiential learning
best created by community-academic partnerships appears to have the ability to stimulate interest and influence intentions
to change health behaviors among middle and high school students. 相似文献
85.
The ability of fentanyl to inhibit drug-induced emesis was investigated in the ferret. Initial studies established that morphine, in small doses (0.025-0.5 mg/kg s.c.), induced emesis in the ferret that decreased at the larger doses of 1 and 2 mg/kg (s.c.). Fentanyl (10-80 micrograms/kg s.c.) failed to induce emesis but in this dose range prevented the emesis induced by morphine (0.5 mg/kg s.c.), apomorphine (0.25 mg/kg s.c.), copper sulphate (100 mg/kg intragastric) and cisplatin (10 mg/kg i.v.). The antiemetic effects could be obtained in the absence of sedation or motor impairment. The antagonism by fentanyl of apomorphine-, copper sulphate- and cisplatin-induced emesis was inhibited by naloxone (0.1 or 0.5 mg/kg s.c.). It is concluded that fentanyl exerts a broad spectrum of actions to inhibit drug-induced emesis. An autoradiographic study of the binding of [3H]DAGO to the brainstem of the ferret indicated high densities of mu recognition sites in the area postrema, nucleus tractus solitarius, dorsal motor nucleus of the vagus, reticular medulla and other sites. The results are discussed in terms of balanced facilitatory and inhibitory opioid systems, regulating emesis and that the antiemetic actions of fentanyl reflect an important, although not necessarily an exclusive, action at mu opioid receptors. 相似文献
86.
87.
The effects of the stable thromboxane A2-mimetic, U46619, on gastric mucosal damage and gastric non-parietal secretion in the rat 总被引:1,自引:1,他引:0 下载免费PDF全文
The effects of the thromboxane A2-mimetic, U46619, and the thromboxane receptor antagonist, AH23848, on ethanol-induced gastric mucosal damage and gastric non-parietal secretion have been examined in the rat. Oral dosing with U46619 or AH23848 produced a dose-related inhibition of ethanol-induced gastric mucosal damage in the conscious rat, and these effects were partially blocked by indomethacin treatment. Intragastric application of U46619 or AH23848 to the stomach of the anaesthetized rat stimulated the gastric secretion of a juice which consisted principally of Na+ and Cl- ions. These secretagogue effects of both compounds were blocked by indomethacin treatment. These results show that U46619 and AH23848 induce secretory and protective effects in the stomach of the rat, although these responses probably do not involve thromboxane receptors and are mediated, at least in part, by endogenous prostaglandins. The results are discussed in relation to the role of endogenous thromboxane A2 in gastric mucosal protection, and of the possible protective function of non-parietal secretion in the stomach. 相似文献
88.
TEELUCKSINGH S; STEER CR; THOMPSON CJ; SECKL JR; DOUGLAS NJ; EDWARDS CRW 《QJM : monthly journal of the Association of Physicians》1991,78(2):185-190
We describe a young man who developed extensive hypothalamicdysfunction including diabetes insipidus, adipsia, hyperprolactinaemia,and poikiliothermia together with central sleep apnoea followingexposure to toluene. 相似文献
89.
In vitro and in vivo activity of murine lymphokine-activated killer cells after cryopreservation 总被引:1,自引:0,他引:1
The in vitro and in vivo effects of cryopreservation on the cytotoxic activity of murine lymphokine-activated killer (LAK) cells were studied. LAK cells were generated by incubation of spleen lymphocytes of BALB/c mice for 3 days with recombinant interleukin-2 (rIL-2) and subsequent cryopreservation. Cytotoxicity was determined in a 51Cr release assay. After thawing, cytotoxic activity was reduced (40.4% 51Cr release at an effector:target cell ratio of 40:1 as compared to 68.5% 51Cr release before freezing) and could be restored to precryopreserved levels by reincubation with rIL-2 for 2 days after thawing (78.8% 51Cr release). These cells were then tested in BALB/c mice injected with RAW 112 cells, a pre-B-cell lymphoma line. The results demonstrate that the survival rate of mice injected with cryopreserved and restimulated LAK cells (50% survival greater than 180 days after injection) did not differ significantly from that of mice injected with fresh unfrozen LAK cells (60% survival greater than 120 days, 50% survival greater than 180 days). Cryopreserved LAK cells have potential use in adoptive immunotherapy. 相似文献
90.
AP Tamhankar FAK Mazari NJ Everitt K Ravi 《Annals of the Royal College of Surgeons of England》2009,91(6):460-463