全文获取类型
收费全文 | 314篇 |
免费 | 6篇 |
国内免费 | 1篇 |
专业分类
耳鼻咽喉 | 19篇 |
儿科学 | 37篇 |
妇产科学 | 4篇 |
基础医学 | 38篇 |
口腔科学 | 10篇 |
临床医学 | 56篇 |
内科学 | 29篇 |
皮肤病学 | 5篇 |
神经病学 | 7篇 |
特种医学 | 30篇 |
外科学 | 21篇 |
综合类 | 23篇 |
预防医学 | 16篇 |
眼科学 | 1篇 |
药学 | 17篇 |
中国医学 | 4篇 |
肿瘤学 | 4篇 |
出版年
2021年 | 4篇 |
2020年 | 2篇 |
2019年 | 6篇 |
2018年 | 2篇 |
2017年 | 2篇 |
2015年 | 5篇 |
2014年 | 23篇 |
2013年 | 22篇 |
2012年 | 19篇 |
2011年 | 11篇 |
2010年 | 11篇 |
2009年 | 13篇 |
2008年 | 4篇 |
2007年 | 8篇 |
2006年 | 7篇 |
2005年 | 4篇 |
2004年 | 2篇 |
2003年 | 8篇 |
2002年 | 3篇 |
2001年 | 2篇 |
2000年 | 7篇 |
1999年 | 2篇 |
1998年 | 13篇 |
1997年 | 18篇 |
1996年 | 11篇 |
1995年 | 9篇 |
1994年 | 10篇 |
1993年 | 12篇 |
1991年 | 4篇 |
1990年 | 5篇 |
1989年 | 3篇 |
1988年 | 1篇 |
1987年 | 1篇 |
1986年 | 1篇 |
1985年 | 1篇 |
1984年 | 3篇 |
1983年 | 2篇 |
1981年 | 2篇 |
1980年 | 1篇 |
1979年 | 1篇 |
1978年 | 3篇 |
1977年 | 1篇 |
1976年 | 1篇 |
1958年 | 1篇 |
1957年 | 2篇 |
1956年 | 2篇 |
1954年 | 2篇 |
1952年 | 16篇 |
1951年 | 23篇 |
1950年 | 2篇 |
排序方式: 共有321条查询结果,搜索用时 390 毫秒
61.
62.
63.
64.
原发性十二指肠恶性肿瘤的X 线诊断 总被引:1,自引:0,他引:1
目的 探讨X线诊断原发性十二指肠恶性肿瘤的价值。方法 回顾性分析 2 1例原发性十二指肠恶性肿瘤的X线所见并与手术病理对照。结果 X线表现包括充盈缺损、黏膜改变、肠腔狭窄和龛影。结论 根据临床及X线表现 ,术前可以正确诊断原发性十二指肠恶性肿瘤。 相似文献
65.
Anderson IA Saukila LF Robins JMW Akhunbay-Fudge CY Goodden JR Tyagi AK Phillips N Chumas PD 《中华神经外科疾病研究杂志》2018,(3)
OBJECTIVE The aim of this study was to provide a comprehensive benchmark of 30-day ventriculoperitoneal(VP)shunt failure rates for a single institution over a 5-year study period for both adult and pediatric patients,to compare this with the results in previously published literature,and to establish factors associated with shunt failure.METHODS A retrospective database search was undertaken to identify all VP shunt operations performed in a single,regional neurosurgical unit during a 5-year period.Data were collected regarding patient age,sex,origin of hydrocephalus,and whether the shunt was a primary or secondary shunt.Operative notes were used to ascertain the type of valve inserted,which components of the shunt were adjusted/replaced(in revision cases),level of seniority of the most senior surgeon who participated in the operation,and number of surgeons involved in the operation.Where appropriate and where available,postoperative imaging was assessed for grade of shunt placement,using a recognized grading system.Univariate and multivariate models were used to establish factors associated with early(30-day)shunt failure.RESULTS Six hundred eighty-three VP shunt operations were performed,of which 321 were pediatric and 362 were adult.The median duration of postoperative follow-up for nonfailed shunts(excluding deaths)was 1263 days(range 525-2226 days).The pediatric 30-day shunt failure rates in the authors'institution were 8.8%for primary shunts and 23.4%for revisions.In adults,the 30-day shunt failure rates are 17.7%for primary shunts and 25.6%for revisions.In pediatric procedures,the number of surgeons involved in the operating theater was significantly associated with shunt failure rate.In adults,the origin of hydrocephalus was a statistically significant variable.Primary shunts lasted longer than revision shunts,irrespective of patient age.CONCLUSIONS A benchmark of 30-day failures is presented and is consistent with current national databases and previously published data by other groups.The number of surgeons involved in shunt operations and the origin of the patient's hydrocephalus should be described in future studies and should be controlled for in any prospective work.The choice of shunt valve was not a significant predictor of shunt failure.Most previous studies on shunts have concentrated on primary shunts,but the high rate of early shunt failure in revision cases(in both adults and children)is perhaps where future research efforts should be concentrated. 相似文献
66.
67.
Muralidhar A Borbon IA Esharif DM Ke W Manacheril R Daines M Erickson RP 《Molecular genetics and metabolism》2011,103(2):142-147
Lung dysfunction is an important part of the pathology of the neurodegenerative disorder, Niemann-Pick C1 (NPC1). We have studied the pulmonary disease in the Npc1(NIH/NIH) mouse model. On histology, we find large numbers of alveolar foamy macrophages but no alveolar proteinosis. Lung weight as percent of body weight was markedly increased; using the flexiVent small animal ventilator (SCIREQ, Inc.), we find inspiratory capacity, elastance and hysterisivity to be increased while resistance was not changed. Cholesterol measurements show a doubling of lung cholesterol levels. Collagen is also increased. Treatment of Npc1(-/-) mice with hydroxypropyl-β-cyclodextrin (HPBCD), despite efficacious effects in brain and liver, results in little difference from age-matched controls (using a CNS-expressed transgene to extend the life expectancy of the Npc1(-/-) mice) for these variables. 相似文献
68.
Michelle IA Rijnders Sita Nys Christel Driessen Christian JPA Hoebe Rogier M Hopstaken Guy J Oudhuis Arno Timmermans Ellen E Stobberingh 《The British journal of general practice》2010,60(581):902-906
Background
The extent to which GPs serve as a reservoir for antibiotic-resistant Staphylococcus aureus is unknown and not well studied.Aim
To determine the prevalence of nasal S. aureus carriage among GPs in the Netherlands, as well as the antimicrobial resistance and the genotypes of isolated S. aureus.Design of study
Observational, point-prevalence, and cross-sectional study.Setting
GPs attending the annual conference of the Dutch College of General Practitioners in 2006.Method
Nasal swabs were randomly taken from 395 GPs and analysed for the presence of S. aureus. Antimicrobial susceptibility was determined by a microbroth dilution method and the genotypes by spa typing, which was associated with multilocus sequence typing.Results
Of the GPs, 129/395 (33%; 95% confidence interval [CI] = 28 to 37%) were carriers of S. aureus. No meticillin-resistant S. aureus (MRSA) was found. Resistance was observed to penicillin (71%; 95% CI = 63 to 79%), fusidic acid (7%; 95% CI = 3 to 13%), and clarithromycin (6%; 95% CI = 3 to 12%). In 72% of the isolates, an MRSA-related genotype of S. aureus was found.Conclusion
The low antibiotic resistance found among S. aureus of GPs suggests that GPs are not a reservoir of antibiotic-resistant S. aureus strains. The relatively high resistance to fusidic acid, which has not previously been described in the Netherlands and is mostly because of antibiotic use, suggests that patients infect GPs and not the other way round. GPs may be at risk for nasal carriage of S. aureus with an MRSA-related genotype. 相似文献69.
70.
ObjectiveTo investigate the neurotransmitter enzyme Acetylcholinesterase (AChE) activity in the brain and blood of rats infected with Trypanosoma congolense (T. congo).MethodsPresence and degree of parasitemia was determined daily for each rat by the rapid matching method. AChE activity was determined by preparing a reaction mixture of brain homogenate and whole blood with 5, 5-dithiobisnitrobenzioc acid (DTNB or Ellman's reagent) and Acetylthiocholine (ATC). The increase in absorbance was recorded at 436 nm over 10 min at 2 min intervals. Trypanosome species identification (before inoculation and on day 10 post infection) was done by Polymerase chain reaction using specific primers.ResultsThe AChE activity in the brain and blood decreased significantly as compared with the uninfected control. The AChE activity dropped to 0.32 from 2.20 μmol ACTC min?1mg protein?1 in the brain and 4.57 to 0.76 μmol ACTC min-1mg protein?1 in the blood. The animals treated with Diminaveto at 3.5 mg/kg/d were observed to have recovered significantly from parasitemia and were able to regain AChE activity in the blood but not in the brain as compared to the control groups. We also observed, that progressive parasitemia resulted to alterations in PCV, Hb, RBC, WBC, neurophils, total protein, lymphocytes, monocytes and eosinophil in acute infections of T. congo. Polymerase chain reaction (PCR) of infected blood before inoculation and on day 10 post infection revealed 600 bp on agarose gel electrophoresis.ConclusionsThis finding suggest that decrease in AChE activity increases acetylcholine concentration in the synaptic cleft resulting to neurological failures in impulse transfer in T. congo infection rats. 相似文献