全文获取类型
收费全文 | 314篇 |
免费 | 6篇 |
国内免费 | 1篇 |
专业分类
耳鼻咽喉 | 19篇 |
儿科学 | 37篇 |
妇产科学 | 4篇 |
基础医学 | 38篇 |
口腔科学 | 10篇 |
临床医学 | 56篇 |
内科学 | 29篇 |
皮肤病学 | 5篇 |
神经病学 | 7篇 |
特种医学 | 30篇 |
外科学 | 21篇 |
综合类 | 23篇 |
预防医学 | 16篇 |
眼科学 | 1篇 |
药学 | 17篇 |
中国医学 | 4篇 |
肿瘤学 | 4篇 |
出版年
2021年 | 4篇 |
2020年 | 2篇 |
2019年 | 6篇 |
2018年 | 2篇 |
2017年 | 2篇 |
2015年 | 5篇 |
2014年 | 23篇 |
2013年 | 22篇 |
2012年 | 19篇 |
2011年 | 11篇 |
2010年 | 11篇 |
2009年 | 13篇 |
2008年 | 4篇 |
2007年 | 8篇 |
2006年 | 7篇 |
2005年 | 4篇 |
2004年 | 2篇 |
2003年 | 8篇 |
2002年 | 3篇 |
2001年 | 2篇 |
2000年 | 7篇 |
1999年 | 2篇 |
1998年 | 13篇 |
1997年 | 18篇 |
1996年 | 11篇 |
1995年 | 9篇 |
1994年 | 10篇 |
1993年 | 12篇 |
1991年 | 4篇 |
1990年 | 5篇 |
1989年 | 3篇 |
1988年 | 1篇 |
1987年 | 1篇 |
1986年 | 1篇 |
1985年 | 1篇 |
1984年 | 3篇 |
1983年 | 2篇 |
1981年 | 2篇 |
1980年 | 1篇 |
1979年 | 1篇 |
1978年 | 3篇 |
1977年 | 1篇 |
1976年 | 1篇 |
1958年 | 1篇 |
1957年 | 2篇 |
1956年 | 2篇 |
1954年 | 2篇 |
1952年 | 16篇 |
1951年 | 23篇 |
1950年 | 2篇 |
排序方式: 共有321条查询结果,搜索用时 15 毫秒
131.
132.
Jeppe Schultz Christensen Ole Raaschou-Nielsen Anne Tj?nneland Kim Overvad Rikke B. Nordsborg Matthias Ketzel Thorkild IA S?rensen Mette S?rensen 《Environmental health perspectives》2016,124(3):329-335
Background
Traffic noise has been associated with cardiovascular and metabolic disorders. Potential modes of action are through stress and sleep disturbance, which may lead to endocrine dysregulation and overweight.Objectives
We aimed to investigate the relationship between residential traffic and railway noise and adiposity.Methods
In this cross-sectional study of 57,053 middle-aged people, height, weight, waist circumference, and bioelectrical impedance were measured at enrollment (1993–1997). Body mass index (BMI), body fat mass index (BFMI), and lean body mass index (LBMI) were calculated. Residential exposure to road and railway traffic noise exposure was calculated using the Nordic prediction method. Associations between traffic noise and anthropometric measures at enrollment were analyzed using general linear models and logistic regression adjusted for demographic and lifestyle factors.Results
Linear regression models adjusted for age, sex, and socioeconomic factors showed that 5-year mean road traffic noise exposure preceding enrollment was associated with a 0.35-cm wider waist circumference (95% CI: 0.21, 0.50) and a 0.18-point higher BMI (95% CI: 0.12, 0.23) per 10 dB. Small, significant increases were also found for BFMI and LBMI. All associations followed linear exposure–response relationships. Exposure to railway noise was not linearly associated with adiposity measures. However, exposure > 60 dB was associated with a 0.71-cm wider waist circumference (95% CI: 0.23, 1.19) and a 0.19-point higher BMI (95% CI: 0.0072, 0.37) compared with unexposed participants (0–20 dB).Conclusions
The present study finds positive associations between residential exposure to road traffic and railway noise and adiposity.Citation
Christensen JS, Raaschou-Nielsen O, Tjønneland A, Overvad K, Nordsborg RB, Ketzel M, Sørensen TI, Sørensen M. 2016. Road traffic and railway noise exposures and adiposity in adults: a cross-sectional analysis of the Danish Diet, Cancer, and Health cohort. Environ Health Perspect 124:329–335; http://dx.doi.org/10.1289/ehp.1409052 相似文献133.
We have developed a self-regulating thermoseed for interstitial hyperthermia treatment of tumors. The seeds are made of a 70.4% nickel-29.6% copper alloy, and they have a Curie point at 50 degrees C. When exposed to an oscillating magnetic field (90 kHz, 50 Oersted amplitude), these seeds show a sharp drop in the rate of heat production at temperatures above the Curie point. In a simulated treatment of a small visceral mass that had negligible blood flow, the tissue temperature stabilized at the Curie point of the alloy with good temperature homogeneity throughout the volume heated by an array of thermoseeds. 相似文献
134.
Germline mutations of the MEN1 gene in familial multiple endocrine neoplasia type 1 and related states 总被引:9,自引:0,他引:9
Agarwal SK; Kester MB; Debelenko LV; Heppner C; Emmert-Buck MR; Skarulis MC; Doppman JL; Kim YS; Lubensky IA; Zhuang Z; Green JS; Guru SC; Manickam P; Olufemi SE; Liotta LA; Chandrasekharappa SC; Collins FS; Spiegel AM; Burns AL; Marx SJ 《Human molecular genetics》1997,6(7):1169-1175
Familial multiple endocrine neoplasia type 1 (FMEN1) is an autosomal
dominant trait characterized by tumors of the parathyroids, gastro-
intestinal endocrine tissue, anterior pituitary and other tissues. We
recently cloned the MEN1 gene and confirmed its identity by finding
mutations in FMEN1. We have now extended our mutation analysis to 34 more
unrelated FMEN1 probands and to two related states, sporadic MEN1 and
familial hyperparathyroidism. There was a high prevalence of heterozygous
germline MEN1 mutations in sporadic MEN1 (8/11 cases) and in FMEN1 (47/50
probands). One case of sporadic MEN1 was proven to be a new MEN1 mutation.
Eight different mutations were observed more than once in FMEN1. Forty
different mutations (32 FMEN1 and eight sporadic MEN1) were distributed
across the MEN1 gene. Most predicted loss of function of the encoded menin
protein, supporting the prediction that MEN1 is a tumor suppressor gene. No
MEN1 germline mutation was found in five probands with familial
hyperparathyroidism, suggesting that familial hyperparathyroidism often is
caused by mutation in another gene or gene(s).
相似文献
135.
Temperatureisanimportantfactorinfluencingthenervoussystem Forinstance ,coolingtherapyhasprotectiveeffectsonacutecerebralvasculardisease However,ifthetemperatureistooloworfluctuating ,itcanexacerbatenervepathology Thiswasconfirmedinmilitaryaccountsduringt… 相似文献
136.
137.
138.
139.
140.
De novo mutations (GAG deletion) in the DYT1 gene in two non-Jewish patients with early-onset dystonia 总被引:3,自引:0,他引:3
Klein C; Brin MF; de Leon D; Limborska SA; Ivanova-Smolenskaya IA; Bressman SB; Friedman A; Markova ED; Risch NJ; Breakefield XO; Ozelius LJ 《Human molecular genetics》1998,7(7):1133-1136
The DYT1 gene recently has been cloned and shown to contain a three
nucleotide (GAG) deletion responsible for most cases of autosomal dominant
early-onset torsion dystonia. This deletion results in the loss of one of a
pair of glutamic acids in a conserved region of a novel ATP-binding protein
(torsinA). Previous haplotype analysis revealed that this same deletion had
arisen at least two different times in history, suggesting independent
mutational events. This deletion is the only sequence change found thus far
to be associated uniquely with the disease status, regardless of ethnic
origin. Here we describe two patients with typical early-onset torsion
dystonia of Swiss-Mennonite and non-Jewish Russian origin, respectively,
that both carry this same mutation as a de novo GAG deletion. This finding
proves that this 3 bp deletion in the DYT1 gene is indeed a mutation that
causes early-onset torsion dystonia. The DYT1 mutation is one of the rare
examples of the same recurrent mutation causing a dominantly inherited
condition. The sequence surrounding the GAG deletion contains an imperfect
24 bp tandem repeat, suggesting a possible mechanism for the high frequency
of this mutation.
相似文献