全文获取类型
收费全文 | 3525篇 |
免费 | 217篇 |
国内免费 | 25篇 |
专业分类
耳鼻咽喉 | 29篇 |
儿科学 | 190篇 |
妇产科学 | 32篇 |
基础医学 | 392篇 |
口腔科学 | 37篇 |
临床医学 | 356篇 |
内科学 | 980篇 |
皮肤病学 | 28篇 |
神经病学 | 243篇 |
特种医学 | 282篇 |
外国民族医学 | 2篇 |
外科学 | 475篇 |
综合类 | 24篇 |
预防医学 | 138篇 |
眼科学 | 203篇 |
药学 | 202篇 |
中国医学 | 6篇 |
肿瘤学 | 148篇 |
出版年
2022年 | 22篇 |
2021年 | 53篇 |
2020年 | 29篇 |
2019年 | 50篇 |
2018年 | 87篇 |
2017年 | 49篇 |
2016年 | 46篇 |
2015年 | 45篇 |
2014年 | 76篇 |
2013年 | 116篇 |
2012年 | 128篇 |
2011年 | 134篇 |
2010年 | 109篇 |
2009年 | 121篇 |
2008年 | 137篇 |
2007年 | 164篇 |
2006年 | 163篇 |
2005年 | 139篇 |
2004年 | 115篇 |
2003年 | 114篇 |
2002年 | 127篇 |
2001年 | 108篇 |
2000年 | 123篇 |
1999年 | 103篇 |
1998年 | 79篇 |
1997年 | 69篇 |
1996年 | 87篇 |
1995年 | 63篇 |
1994年 | 57篇 |
1993年 | 56篇 |
1992年 | 73篇 |
1991年 | 49篇 |
1990年 | 65篇 |
1989年 | 89篇 |
1988年 | 59篇 |
1987年 | 81篇 |
1986年 | 79篇 |
1985年 | 58篇 |
1984年 | 41篇 |
1983年 | 31篇 |
1982年 | 29篇 |
1981年 | 24篇 |
1979年 | 20篇 |
1977年 | 19篇 |
1976年 | 23篇 |
1975年 | 34篇 |
1974年 | 21篇 |
1970年 | 21篇 |
1966年 | 18篇 |
1965年 | 21篇 |
排序方式: 共有3767条查询结果,搜索用时 15 毫秒
11.
Low molecular weight heparin fractions as an alternative therapy in heparin-induced thrombocytopenia
M Gouault-Heilmann Y Huet S Adnot G Contant F Bonnet L Intrator D Payen M Levent 《Haemostasis》1987,17(3):134-140
Eight patients with a delayed-onset heparin-induced thrombocytopenia, with thrombotic complications requiring immediate anticoagulation in 7 of them, were given low molecular weight heparin (LMWH) fractions as alternative therapy. This treatment led to normalization of platelet count within 3-5 days in 6 patients with clinical recovery in 5. In 2 patients, thrombocytopenia persisted despite LMWH therapy. In vitro platelet aggregation tests performed in all patients gave evidence of a relationship between the presence (or absence) of a LMWH-dependent platelet-aggregating factor in the patients' plasma and the persistence (or correction) of the thrombocytopenia with LMWH therapy. Although positive in vitro tests may not necessarily be associated with thrombocytopenia, in vitro testing may prove to be a useful guide before giving LMWH fractions as an alternative therapy in patients with heparin-induced thrombocytopenia requiring immediate anticoagulation. 相似文献
12.
13.
14.
15.
16.
17.
A Bourdeau J C Souberbielle P Bonnet P Herviaux C Sachs M Lieberherr 《Endocrinology》1992,130(3):1339-1344
The involvement of arachidonic acid (AA) and its metabolites in the control of PTH secretion by porcine parathyroid cells was investigated. Increasing the extracellular calcium concentration from 0.5 to 2 mM increased free [3H]AA release and decreased PTH secretion from labeled parathyroid cells as a function of time (1-30 min). Free [3H]AA in the medium was significantly increased (+153 +/- 6%) after 5 min, while PTH secretion was significantly decreased (-75 +/- 7%) only after 15 min, suggesting a link between the two. [3H]AA release was associated with a decrease in [3H]AA incorporated into phosphatidylinositol, phosphatidic acid, and phosphatidylcholine, suggesting that these phospholipids are the major source of AA. Exogenous phospholipase-A2 (PL-A2; 1-500 mU/ml) and AA (5-40 microM) inhibited PTH secretion in a dose-dependent manner. PTH secretion inhibited by 2 mM Ca2+ was restored by two PL-A2 inhibitors, indomethacin (30 microM) and mepacrine (50 microM). The cyclooxygenase pathway inhibitor ibuprofen (20 microM) did not restore PTH secretion of affect high Ca(2+)-, AA-, or PL-A2-inhibited PTH secretion. Two inhibitors of the lipoxygenase pathway (LO), phenidone (1 microM) and baicalein (0.1 microM), a relatively selective 12-LO inhibitor, blunted high Ca(2+)-induced inhibition of PTH secretion (+101 +/- 10% and +105 +/- 6%, respectively), but nordihydroguaiaretic acid, which inhibits the 5-LO pathway, did not restore PTH secretion inhibited by high Ca2+, AA, or PL-A2. These results suggested that AA and agents that cause its liberation inhibit PTH secretion. AA may act via the 12-LO, but not via the 5-LO or cyclooxygenase, pathway. Thus, 12-LO products may be second messengers in parathyroid cells. 相似文献
18.
R Andrianne C Vandeberg P Bonnet H Nicolas L Coppens C Bouffioux J de Leval 《European urology》1992,22(2):134-136
Extracorporeal shockwave lithotripsy (ESWL) has been initially designed for stones located in the kidney and the upper ureter. Our lithotripter is no exception. Its components (the table and the orientation of the semi-ellipsoid reflector) are adapted for the treatment of kidney or lumbar ureter stones. However, the elements forming the unit of treatment (the table, the C-arm and the Tripter) can be modified in such a way that focalization of stones of the lower ureter becomes possible through a perineal exposure. The aim is to avoid the pelvic bone shield while a good focalization of the stone is realized. From June 1989 to March 1991, 35 patients were treated for distal ureteric stones by ESWL in this original positioning. 相似文献
19.
Siamak Mohammadi Giuseppe Silvaggio Nicolas Bonnet George Berberian Richard Dorent Marc Bikter Alain Pavie Iradj Gandjbakhch 《The Journal of heart and lung transplantation》2005,24(8):995-997
BACKGROUND: We have noted an unexpectedly high incidence of prostate cancer in our heart transplant recipients (HTR). METHODS: We conducted a retrospective review of patients after heart transplantation to investigate the prevalence, treatment, and outcome of prostate cancer diagnosed after systematic screening (study group). We compared them with case-matched HTR (control). RESULTS: Among 702 recipients, 15 patients had elevated prostate-specific antigen (PSA) levels. Fourteen cases of prostate cancer were diagnosed and treated. The median time between transplantation and prostate cancer diagnosis was 73 months. No patient was diagnosed in a locally advanced (>T2) or metastatic stage. Eleven patients (78.6%) received curative treatment. During follow-up (median, 44 months), 1 patient died from prostate cancer. The survival rate between the study and control groups did not differ. CONCLUSION: Routine PSA testing is recommended as a screening test for prostate cancer in patients after heart transplantation. We believe this could also result in detection of early stages of prostate cancer, thus allowing curative treatment, and achieving similar survival to other case-matched HTR with no prostate cancer. 相似文献