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81.
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Emi Sasagawa Hirotsugu Aiga Edith Yanira Corado Soriano Blanca Leticia Cuyuch Marroquín Marta Alicia Hernández Ramírez Ana Vilma Guevara de Aguilar José Eduardo Romero Chévez Hector Manuel Ramos Hernández Rafael Antonio Cedillos Chizuru Misago Kiyoshi Kita 《The American journal of tropical medicine and hygiene》2015,93(2):326-333
To estimate the incidence (any mother to child) and rate (from seropositive mother to child) of mother-to-child transmission of Trypanosoma cruzi, a serological census was conducted, targeting pregnant women and infants born to seropositive mothers, in four municipalities of El Salvador. Of 943 pregnant women, 36 (3.8%) were seropositive for T. cruzi. Of 36, 32 proceeded to serological tests of their infants when they became 6–8 months of age. Six infants seropositive at the age of 6–8 months further proceeded to second-stage serological test at the age of 9–16 months. As the result, one infant was congenitally infected. Thus, serological tests at the age of 6–8 months produced five false positives. To ensure earlier effective medication only for true positives, identification of seropositive infants at the age of 9–16 months is crucial. Incidence and rate of mother-to-child transmission were 0.14 (per 100 person-years) and 4.0%, respectively. Estimated number of children infected through mother-to-child transmission in El Salvador (170 per year) was much higher than that of human immunodeficiency virus (HIV; seven per year). It is recommended that serological testing for T. cruzi be integrated into those for HIV and syphilis as part of antenatal care package. 相似文献
83.
Amador García-Ramos Igor ?tirn Paulino Padial Javier Argüelles-Cienfuegos Blanca De la Fuente Vojko Strojnik Belén Feriche 《Journal of Sports Science and Medicine》2015,14(2):256-262
The objective of the study was to assess the use of maximum (Vmax) and final propulsive phase (FPV) bar velocity to predict jump height in the weighted jump squat. FPV was defined as the velocity reached just before bar acceleration was lower than gravity (-9.81 m·s-2). Vertical jump height was calculated from the take-off velocity (Vtake-off) provided by a force platform. Thirty swimmers belonging to the National Slovenian swimming team performed a jump squat incremental loading test, lifting 25%, 50%, 75% and 100% of body weight in a Smith machine. Jump performance was simultaneously monitored using an AMTI portable force platform and a linear velocity transducer attached to the barbell. Simple linear regression was used to estimate jump height from the Vmax and FPV recorded by the linear velocity transducer. Vmax (y = 16.577x - 16.384) was able to explain 93% of jump height variance with a standard error of the estimate of 1.47 cm. FPV (y = 12.828x - 6.504) was able to explain 91% of jump height variance with a standard error of the estimate of 1.66 cm. Despite that both variables resulted to be good predictors, heteroscedasticity in the differences between FPV and Vtake-off was observed (r2 = 0.307), while the differences between Vmax and Vtake-off were homogenously distributed (r2 = 0.071). These results suggest that Vmax is a valid tool for estimating vertical jump height in a loaded jump squat test performed in a Smith machine.
Key points
- Vertical jump height in the loaded jump squat can be estimated with acceptable precision from the maximum bar velocity recorded by a linear velocity transducer.
- The relationship between the point at which bar acceleration is less than -9.81 m·s-2 and the real take-off is affected by the velocity of movement.
- Mean propulsive velocity recorded by a linear velocity transducer does not appear to be optimal to monitor ballistic exercise performance.
84.
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87.
Eric Gustavo Ramírez-Salazar Luis Carlos Salinas-Silva Maria Eugenia Vázquez-Manríquez Luis Vicente Gayosso-Gómez Maria Cristina Negrete-Garcia Sandra Lizbeth Ramírez-Rodriguez Raúl Chávez Edgar Zenteno Patricio Santillán Javier Kelly-García Blanca Ortiz-Quintero 《Experimental and molecular pathology》2014
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89.
Interstitial 13q14 deletions detected in the karyotype and translocations with concomitant deletion at 13q14 in chronic lymphocytic leukemia: Different genetic mechanisms but equivalent poorer clinical outcome 下载免费PDF全文
Anna Puiggros Marta Venturas Marta Salido Gonzalo Blanco Concepcin Fernandez‐Rodriguez Rosa Collado Alberto Valiente Neus Ruiz‐Xivill Ana Carri Francisco Jos Ortuo Elisa Luo María Jos Calasanz María Teresa Ardanaz María ngeles Pin Elisabet Talavera María Teresa Gonzlez Margarita Ortega Isabel Marugn Ana Ferrer Eva Gimeno Beatriz Bellosillo Julio Delgado Jos ngel Hernndez Jesús María Hernndez‐Rivas Blanca Espinet 《Genes, chromosomes & cancer》2014,53(9):788-797
Deletion of 13q14 as the sole abnormality is a good prognostic marker in chronic lymphocytic leukemia (CLL). Nonetheless, the prognostic value of reciprocal 13q14 translocations [t(13q)] with related 13q losses has not been fully elucidated. We described clinical and biological characteristics of 25 CLL patients with t(13q), and compared with 62 patients carrying interstitial del(13q) by conventional G‐banding cytogenetics (CGC) [i‐del(13q)] and 295 patients with del(13q) only detected by fluorescence in situ hybridization (FISH) [F‐del(13q)]. Besides from the CLL FISH panel (D13S319, CEP12, ATM, TP53), we studied RB1 deletions in all t(13q) cases and a representative group of i‐del(13q) and F‐del(13q). We analyzed NOTCH1, SF3B1, and MYD88 mutations in t(13q) cases by Sanger sequencing. In all, 25 distinct t(13q) were described. All these cases showed D13S319 deletion while 32% also lost RB1. The median percentage of 13q‐deleted nuclei did not differ from i‐del(13q) patients (73% vs. 64%), but both were significantly higher than F‐del(13q) (52%, P < 0.001). Moreover, t(13q) patients showed an increased incidence of biallelic del(13q) (52% vs. 11.3% and 14.9%, P < 0.001) and higher rates of concomitant 17p deletion (37.5% vs. 8.6% and 7.2%, P < 0.001). RB1 involvement was significantly higher in the i‐del(13q) group (79%, P < 0.001). Two t(13q) patients (11.8%) carried NOTCH1 mutations. Time to first treatment in t(13q) and i‐del(13q) was shorter than F‐del(13q) (67, 44, and 137 months, P = 0.029), and preserved significance in the multivariate analysis. In conclusion, t(13q) and del(13q) patients detected by CGC constitute a subgroup within the 13q‐deleted CLL patients associated with a worse clinical outcome. © 2014 Wiley Periodicals, Inc. 相似文献
90.
Blanca Scheijen Josephine T. Tauer Christina Nowasz Edwin Sonneveld Geertruida H. de Bock Tiny G. J. Meeuwsen‐de Boer Simon van Reijmersdal Roland P. Kuiper Jutta Bradtke Frank N. van Leeuwen 《British journal of haematology》2014,166(2):250-253
Early recognition of children with chronic phase chronic myeloid leukaemia (CML‐CP) at risk for developing a lymphoid blast crisis (LyBC) is desirable, because therapy options in CML‐LyBC are limited. We used Multiplex Ligation‐dependent Probe Amplification to determine whether B‐cell lymphoid leukaemia‐specific copy number alterations (CNAs) (e.g. IKZF1, PAX5, CDKN2A deletions) could be detected in CML‐CP and may be used to predict disease progression to LyBC. CNAs were detected in all patients with CML‐LyBC, but in none of the 77 patients with CML‐CP. Based on this study we conclude that CNAs remain a hallmark of disease progression. 相似文献