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排序方式: 共有727条查询结果,搜索用时 15 毫秒
71.
Wang B Dolinski BM Kikuchi N Leone DR Peters MG Weinreb PH Violette SM Bissell DM 《Hepatology (Baltimore, Md.)》2007,46(5):1404-1412
Acute biliary obstruction leads to periductal myofibroblasts and fibrosis, the origin of which is uncertain. Our study provides new information on this question in mice and humans. We show that bile duct obstruction induces a striking increase in cholangiocyte alphavbeta6 integrin and that expression of this integrin is directly linked to fibrogenesis through activation of transforming growth factor beta (TGF-beta). Administration of blocking antibody to alphavbeta6 significantly reduces the extent of acute fibrosis after bile duct ligation. Moreover, in beta6-null mice subjected to the injury, fibrosis is reduced by 50% relative to that seen in wild-type mice, whereas inflammation occurs to the same extent. The data indicate that alphavbeta6, rather than inflammation, is linked to fibrogenesis. It is known that alphavbeta6 binds latent TGF-beta and that binding results in release of active TGFbeta. Consistent with this, intracellular signaling from the TGFbeta receptor is increased after bile duct ligation in wild-type mice but not in beta6(-/-) mice, and a competitive inhibitor of the TGFbeta receptor type II blocks fibrosis to the same extent as antibody to alphavbeta6. In a survey of human liver disease, expression of alphavbeta6 is increased in acute, but not chronic, biliary injury and is localized to cholangiocyte-like cells. CONCLUSION: Cholangiocytes respond to acute bile duct obstruction with markedly increased expression of alphavbeta6 integrin, which is closely linked to periductal fibrogenesis. The findings provide a rationale for the use of inhibitors of alphavbeta6 integrin or TGFbeta for down-regulating fibrosis in the setting of acute or ongoing biliary injury. 相似文献
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Huang C Park CC Hilsenbeck SG Ward R Rimawi MF Wang YC Shou J Bissell MJ Osborne CK Schiff R 《Breast cancer research : BCR》2011,13(4):R84
Introduction
The overexpression of human epidermal growth factor receptor (HER)-2 in 20% of human breast cancers and its association with aggressive growth has led to widespread use of HER2-targeted therapies, such as trastuzumab (T) and lapatinib (L). Despite the success of these drugs, their efficacy is limited in patients whose tumors demonstrate de novo or acquired resistance to treatment. The β1 integrin resides on the membrane of the breast cancer cell, activating several elements of breast tumor progression including proliferation and survival. 相似文献74.
75.
Abstract The purpose of the present study was to investigate how bright light during the daytime could influence circadian rhythms of core temperature and nocturnal sleep. Seven females (age 20 ± 2 years) served as participants. The participants lived in the experimental unit for 4 days and were exposed to either 6000 lx (bright) or 200 lx (dim) light during the daytime. Rectal temperature (Tre ) was measured during the experimental period. Subjective alertness was measured by the Kansei-gakuin Sleeping Scale five times a day. The minimum Tre was significantly lower after bright exposure ( P < 0.05). The Tre fell rapidly after bright exposure before they retired ( P < 0.05) and increased more rapidly during bright light after they woke up ( P < 0.05). The morning wakefulness under bright exposure was more active than under dim exposure ( P < 0.05). The melatonin secretion at wake up during bright exposure was significantly lower than during dim exposure ( P < 0.05). Exposure to bright light during daytime lowered the nocturnal level of Tre , its evening fall was faster and the morning rise quicker. This suggests that indoor light during daytime should be bright enough to promote healthy sleep at night. 相似文献
76.
Virginia A. Spencer Ren Xu Mina J. Bissell 《Journal of mammary gland biology and neoplasia》2010,15(1):65-71
Decades ago, we and others proposed that the dynamic interplay between a cell and its surrounding environment dictates cell
phenotype and tissue structure. Whereas much has been discovered about the effects of extracellular matrix molecules on cell
growth and tissue-specific gene expression, the nuclear mechanisms through which these molecules promote these physiological
events remain unknown. Using mammary epithelial cells as a model, the purpose of this review is to discuss how the extracellular
matrix influences nuclear structure and function in a three-dimensional context to promote epithelial morphogenesis and function
in the mammary gland. 相似文献
77.
Rajiv N. Reebye Anthony J. Avery Paul Bissell Chris van Weel 《The International journal of pharmacy practice》2002,10(2):69-75
This paper discusses the utility of the concept of territoriality in order to understand relationships between pharmacists and physicians in the primary care setting. First, we provide background information on the concept of human territoriality. Secondly, we discuss its potential application to the relationships between pharmacists and physicians. Finally, we suggest ways in which understanding and tackling territorial issues may strengthen the pharmacist‐physician link and, in doing so, may improve patient care. 相似文献
78.
Ole W. Petersen M.D. D.M.Sc. †Lone Rønnov-Jessen M.Sc. †Mina J. Bissell Ph.D. 《The breast journal》1995,1(1):22-35
Abstract: Sensitive assays that recapitulate the complex and dynamic interaction of cells within the breast are needed to understand the early steps by which normal breast cells become cancerous, and cancer cells become invasive. We discuss the literature of available culture systems and elaborate on two assays we have developed to study interaction of normal and tumor cells with stromal cells and ECM in three dimensions. The assays highlight the significance of cell:cell and cell-extracellular matrix interactions in functional differentiation of the breast epithelium and should provide valuable tools in understanding breast cancer. 相似文献
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