Therapeutic Potentials of Oroxylum indicum Bark Extracts

AIM:Diverse therapeutic potentials of methanolic and aqueous extracts of Oroxylum indicum(L.)Vent.bark,includ- ing antioxidant property,cytotoxicity and protection against oxidative DNA damage were investigated in this study.METHODS:Total phenolics in the extracts were determined by spectrophotometric method.Ferric reducing antioxidant property(FRAP),free radical (DPPH·and ·OH)scavenging activities,as well as inhibitory effect on lipid peroxidation have been investigated.Cytotoxicity of the extracts was inv...     

前列腺素F_(2α)放射免疫分析及其应用

前列腺素F_(2α)(PGF_(2α))是生物体内的重要活性物质,对机体起多种调节作用。为推动前列腺素的定量研究,本文参考Granstrom等方法”’略加改进,获得了亲和力高、特异性强的PGF_(2α)抗体,建成了灵敏、准确,精密和操作简便的RIA方法,用此法测定了人和几种动物血浆与组织中PGF_(2α)的正常含量。     

Contextual influence on the tilt after-effect in foveal and parafoveal vision

A sensory stimulus can only be properly interpreted in light of the stimuli that surround it in space and time. The tilt illusion(TI) and tilt after-effect(TAE) provide good evidence that the perception of a target depends strongly on both its spatial and temporal context. In previous studies, the TI and TAE have typically been investigated separately, so little is known about their co-effects on visual perception and information processing mechanisms. Here, we considered the influence of the spatial context and the temporal effect together and asked how centersurround context affects the TAE in foveal and parafoveal vision. Our results showed that different center-surround spatial patterns signifi cantly affected the TAE for both foveal and para-foveal vision. In the fovea, the TAE was mainly produced by central adaptive gratings. Cross-oriented surroundings significantly inhibited the TAE, and iso-oriented surroundings slightly facilitated it; surround inhibition was much stronger than surround facilitation. In the para-fovea, the TAE was mainly decided by the surrounding patches. Likewise, a cross-oriented central patch inhibited the TAE, and an iso-oriented one facilitated it, but there was no significant difference between inhibition and facilitation. Our findings demonstrated, at the perceptual level, that our visual system adopts different mechanisms to process consistent or inconsistent central-surround orientation information and that the unequal magnitude of surround inhibition and facilitation is vitally important for the visual system to improve the detectability or discriminability of novel or incongruent stimuli.     

结直肠癌中PTEN的缺失表达及临床意义

目的:研究PTEN在结直肠癌中的表达及其与结直肠癌病理特征的关系．方法:应用免疫组化SP法分别检测65例癌组织和癌旁组织及13例腺瘤组织PTEN蛋白的表达．结果:PTEN主要在细胞核或细胞质中表达,在结直肠癌组织中阳性表达率显著低于癌旁组织阳性表达率(56．92% vs 86．15％,P<0．01)．中、高分化腺癌阳性表达率显著高于低、未分化腺癌阳性表达率(75．76% vs 37．50％, P<0．01)．Dukes A、B期阳性表达率显著高于Dukes C、D期阳性表达率(73．33％vs 42．86％, P<0．05)．此外,PTEN的表达与淋巴转移有关(P<0．01),而与性别、年龄、同期的肿瘤大小无关．结论:PTEN在结直肠癌组织中的表达下调,其表达水平可作为反映结直肠癌进展和预后的生物学指标之一．     

Tetralogy of Fallot with Cor Triatriatum Dexter in an Adult Patient: A Case Report

Tetralogy of Fallot (TOF) is the most common cyanotic congenital heart defect with only approximately 3% of uncorrected patients surviving past age 40. In this case report, we present a 48‐year‐old mentally retarded man suffering from congenital spastic quadriplegia who was diagnosed with a unique combination of symptomatic TOF and cor triatriatum dexter (CTD). Reduced preload because of CTD with spastic quadriplegia that prevented physical exertion is believed to have facilitated this patient's unusually long survival.     

聚乙二醇修饰干扰素α2b抗肿瘤细胞增殖作用

目的：研究基因工程干扰素α2b和聚乙二醇（PEG）修饰干扰素α2b的抗肿瘤细胞增殖效应。方法：采用MTT法将不同浓度的干扰素分别对几种肿瘤细胞进行生长抑制实验。结果：不同终浓度（500ng/ml,50ng/ml,5ng/ml,0.5ng/ml)干扰素α2b和PEG修饰干扰素α2b对人肝癌细胞（SMMC－7721）、人红白血病细胞（K562）、人宫颈癌细胞（HeLa)、人鼻咽癌细胞（KB）和人胃癌细胞（BGC）的生长均有不同程度的抑制作用。结论：聚乙二醇修饰干扰素的抗肿瘤细胞增殖作用优于干扰素。