Clinical Efficacy of Cervical Length and Volume for Prediction of Labor Onset in VBAC Candidates

Background: The purpose of this research is to discover whether measurement of cervical length and cervical volume at term is helpful in predicting the onset of labor in VBAC candidates.Methods: Transvaginal sonographic evaluations of the cervixes of pregnant women who desired to undergo VBAC were performed between 36 - 40 weeks gestation. Clinical information such as labor onset time, gestational age at delivery and delivery mode was gathered from medical records.Results: A total of 514 pregnant women participated in this study. Cervical length was significantly longer in the group that delivered 7 days or more after measurement than in the group that delivered within 7 days of measurement (43±0.77 cm vs. 2.99±0.72 cm, p< 0.001). Cervical volume was significantly larger in the group that delivered at and after 7 days than in the group that delivered within 7 days (29.21±11.62 cm³ vs. 34.07±13.41 cm³, p=0.014). The cervical length ROC curve was significantly more predictive than the cervical volume ROC curve (AUC: 0.711 vs 0.594, p= 0.001). There were no significant differences between the combined cervical length/volume ROC curve and the cervical length ROC curve alone (p= 0.565). The AUC of the cervical length ROC curve to predict postterm pregnancy was 0.729.Conclusion: Measuring cervical length is helpful in predicting the onset of spontaneous labor within 7 days and posterm delivery in VBAC candidates.     

Blocking “don't eat me” signal of CD47-SIRPα in hematological malignancies,an in-depth review

Hematological malignancies express high levels of CD47 as a mechanism of immune evasion. CD47-SIRPα triggers a cascade of events that inhibit phagocytosis. Preclinical research supports several models of antibody-mediated blockade of CD47-SIRPα resulting in cell death signaling, phagocytosis of cells bearing stress signals, and priming of tumor-specific T cell responses. Four different antibody molecules designed to target the CD47-SIRPα interaction in malignancy are currently being studied in clinical trials: Hu5F9-G4, CC-90002, TTI-621, and ALX-148. Hu5F9-G4, a humanized anti-CD47 blocking antibody is currently being studied in four different Phase I trials. These studies may lay the groundwork for therapeutic bispecific antibodies. Bispecific antibody (CD20-CD47SL) fusion of anti-CD20 (Rituximab) and anti-CD47 also demonstrated a synergistic effect against lymphoma in preclinical models. This review summarizes the large body of preclinical evidence and emerging clinical data supporting the use of antibodies designed to target the CD47-SIRPα interaction in leukemia, lymphoma and multiple myeloma.     

Serum Metabonomics of Articular Cartilage Destruction Induced by T-2 Toxin in Wistar Rats

正The molecular pathogenesis of T-2toxin-induced cartilage destruction has not been fully unraveled yet.The aim of this study was to detect changes in serum metabolites in a rat anomaly model with articular cartilage destruction.Thirty healthy male Wistar rats were fed a diet containing T-2 toxin(300 ng/kg chow)for 3 months.     

某化工厂附近居民肿瘤患病情况调查

目的了解某化工厂附近居民肿瘤患病情况。方法采取回顾性问卷调查和现场健康检查,对该化工厂附近143名居民进行现场流行病学调查,调查分析环境中存在的可疑致病因素,利用统计学Poisson分布直接概率计算方法,将该厂附近居民肿瘤患病情况与全国平均患病水平(276.16/10万)进行统计学处理、比较。结果该厂附近居民5年肿瘤平均患病率为136.10/10万,与全国平均水平进行比较,差异无统计学意义(P=0.055 3)。结论该厂附近居民肿瘤患病率不高于全国平均患病率。     

甲状腺癌再手术中甲状旁腺损伤的危险因素及功能保护措施分析

目的 探究甲状腺癌再手术中甲状旁腺损伤的危险因素及功能保护措施.方法 选取2017年8月至2020年8月本院收治的80例甲状腺癌再手术患者为研究对象,以甲状旁腺是否损伤分为两组,各40例.观察组为甲状旁腺损伤,对照组为甲状旁腺未损伤,比较两组临床资料,总结相关危险因素,并制定针对性功能保护措施.结果 单因素分析结果显示,观察组原切口入路率、Ⅵ区淋巴结清扫占比均明显高于对照组,差异有统计学意义(P<0.05).Logistic回归分析显示,原切口入路、行Ⅵ区淋巴结清扫均是甲状腺癌再手术中甲状旁腺损伤的独立危险因素.结论 手术入路、Ⅵ区淋巴结清扫均是甲状腺癌再手术中甲状旁腺损伤的危险因素,为保护甲状旁腺功能,再手术中需综合评估、合理操作,减少损伤.     

医院管理决策中统计信息的应用

医院决策层的决策及其对医院工作的指导和改进建议,都是在对医院以往各项统计数据进行认真分析总结的基础上进行的。实际上医院的统计工作的目的和意义,在一定程度上也正是为医院决策层的科学决策提供有价值的参考。医院决策层通过医院的统计数据,能够对上年度计划的执行情况进行监督和检查;掌握医疗设备及床位的配置和使用的真实情况,能够通过对住院患者疾病种类、死亡率、死因、住院费用对患者的影响等一系列信息的统计分析,制定有效的管理政策、充分利用医疗设备、降低死亡率,把握医疗市场的新动向,实现优质高效管理。