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Thi-Kim-Chi Huynh Thi-Hong-An Nguyen Thi-Cam-Thu Nguyen Thi-Kim-Dung Hoang 《RSC advances》2020,10(35):20543
In order to explore and develop new anticancer agents, three series of 2-phenylbenzimidazoles, 15–46, were condensed under simple and mild conditions using sodium metabisulfite as an oxidation agent and another series, 47–55, were obtained via a reduction reaction using sodium borohydride. All the compounds synthesized were evaluated for their in vitro anticancer activities against three human cancer cell lines. The novel compound 38 was found to be the most potent multi cancer inhibitor against A549, MDA-MB-231, and PC3 cell lines (IC50 values 4.47, 4.68 and 5.50 μg mL−1, respectively). In addition, compound 40 exhibited the best IC50 value of 3.55 μg mL−1 against the MDA-MB-231 cell line. The results demonstrated that introducing a new substituent to compounds 37–55 could improve their antiproliferative activities.Three series of 2-phenylbenzimidazoles obtained under simple and convenient pathways, were used to elucidate their SARs against three cancer cell lines: A549, MDA-MB-231 and PC3. 相似文献
84.
Nguyen Tat Thang Le Thi Hong Nguyen Hoang Thoan Chu Manh Hung Nguyen Van Duy Nguyen Van Hieu Nguyen Duc Hoa 《RSC advances》2020,10(22):12759
Fabrication of a high-performance room-temperature (RT) gas sensor is important for the future integration of sensors into smart, portable and Internet-of-Things (IoT)-based devices. Herein, we developed a NO2 gas sensor based on ultrathin MoS2 nanoflowers with high sensitivity at RT. The MoS2 flower-like nanostructures were synthesised via a simple hydrothermal method with different growth times of 24, 36, 48, and 60 h. The synthesised MoS2 nanoflowers were subsequently characterised by scanning electron microscopy, X-ray diffraction, Raman spectroscopy, energy-dispersive X-ray spectroscopy and transmission electron microscopy. The petal-like nanosheets in pure MoS2 agglomerated to form a flower-like structure with Raman vibrational modes at 378 and 403 cm−1 and crystallisation in the hexagonal phase. The specific surface areas of the MoS2 grown at different times were measured by using the Brunauer–Emmett–Teller method. The largest specific surface area of 56.57 m2 g−1 was obtained for the MoS2 nanoflowers grown for 48 h. This sample also possessed the smallest activation energy of 0.08 eV. The gas-sensing characteristics of sensors based on the synthesised MoS2 nanostructures were investigated using oxidising and reducing gases, such as NO2, SO2, H2, CH4, CO and NH3, at different concentrations and at working temperatures ranging from RT to 150 °C. The sensor based on the MoS2 nanoflowers grown for 48 h showed a high gas response of 67.4% and high selectivity to 10 ppm NO2 at RT. This finding can be ascribed to the synergistic effects of largest specific surface area, smallest crystallite size and lowest activation energy of the MoS2-48 h sample among the samples. The sensors also exhibited a relative humidity-independent sensing characteristic at RT and a low detection limit of 84 ppb, thereby allowing their practical application to portable IoT-based devices.Controlled synthesis of ultrathin MoS2 nanoflowers is crucial to develop a high-performance room-temperature NO2 gas sensor for the future integration of sensors into smart, portable and Internet-of-Things (IoT)-based devices. 相似文献
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Roxann Roberson-Nay Erin C. Berenz Ron Acierno Trinh Luong Tran Lam Tu Trung Nguyen Thanh Tam Tran Tuan La Thi Buoi Tran Thu Ha Tran Duc Thach Ananda B. Amstadter 《Psychiatry research》2013
The association between trauma exposure and panic attacks has received increased attention over the past decade, with mounting evidence suggesting an overlapping etiologic pathway. This study examined the incidence of new onset panic attacks in 775 Vietnamese individuals in the 2–3 months following Typhoon Xangsane. Pre-typhoon (Wave 1) and post-typhoon (Wave 2) assessments were conducted, allowing for consideration of factors occurring prior to the typhoon in addition to typhoon-relevant responding. Of the 775 participants, 11.6% (n=90) met criteria for lifetime panic attack pre-typhoon and 2.8% (n=22) met post-typhoon panic attack criteria. Individuals with pre-typhoon panic were significantly older and reported less education compared to the no-panic group. Individuals in both panic groups were more likely to screen positive on a Wave1 psychiatric screening measure, endorse greater typhoon exposure and prior traumatic event exposure and were significantly more likely to meet DSM-IV criteria for posttraumatic stress disorder (PTSD) and major depression (MDD) post-typhoon compared with persons reporting no history of panic attacks. Pre and post-typhoon panic exhibited similar patterns across variables and both panic conditions were associated with the development of PTSD and MDD, suggesting that persons experiencing panic attacks may represent a vulnerable population in need of early intervention services. 相似文献
86.
Ha Hao Huu Nguyen Trang Hong Tran Linh Huyen Nguyen Hanh Thi Hong Hoang Ha Chu Hoang Ha 《International journal of legal medicine》2019,133(5):1403-1404
We collected and analysed the genetic characteristics of 23 Y-STR data of 200 unrelated Kinh individuals living in the North of Vietnam. Haplotype frequencies and forensic parameters were calculated, showing high discrimination value. Population comparison analysis was performed to determine the genetic relationship with neighbouring ethnicities, in particular with Thai and Han populations.
相似文献87.
Stella K. Kang Lincoln L. Berland William W. Mayo-Smith Jenny K. Hoang Brian R. Herts Alec J. Megibow Pari V. Pandharipande 《Journal of the American College of Radiology》2019,16(5):700-708
The lack of prospective outcomes studies for many types of incidental findings limits our understanding of both their natural history and the potential efficacy of treatment. To support decision making for the management of incidental findings, major sources of uncertainty in management pathways can be mapped and analyzed using mathematical models. This process yields important insights into how uncertainty influences the best treatment decision. Here, we consider a classification scheme, grounded in decision science, which exposes various levels and types of uncertainty in the management of incidental findings and addresses (1) disease-related risks, which are considered in context of a patient’s competing causes of mortality; (2) potential degrees of intervention; (3) strength of evidence; and (4) patients’ treatment-related preferences. Herein we describe how categorizing uncertainty by the sources, issues, and locus can build a framework from which to improve the management of incidental findings. Accurate and comprehensive handling of uncertainty will improve the quality of related decision making and will help guide future research priorities. 相似文献
88.
Rosalie M. Grijalva BS Nha Trang Thu Pham BS Qiao Huang PhD Peter R. Martin MS Farwa Ali MD Heather M. Clark PhD Joseph R. Duffy PhD Rene L. Utianski PhD Hugo Botha MD Mary M. Machulda PhD Stephen D. Weigand MS J. Eric Ahlskog PhD MD Dennis W. Dickson MD Keith A. Josephs MD MST MSc Jennifer L. Whitwell PhD 《Movement disorders》2022,37(4):702-712
89.
Anja Dessauvagie Hoang-Minh Dang Tuyet Truong Thu Nguyen Bich Hong Nguyen Huong Cao Socheata Kim Gunter Groen 《International Journal of Mental Health Promotion, The》2022,24(3):439-456
Mental health literacy (MHL) refers to knowledge and attitudes that shape the recognition, management, and prevention of mental disorders. While the topic has been exhaustively researched in Western countries, research from Southeast Asia still is limited. Previous studies in this field showed a moderate recognition of mental disorders, a high prevalence of stigmatizing attitudes and a low willingness to seek professional help among Southeastern-Asian populations. This study explored the level of MHL among university students from different parts of Vietnam and Cambodia. Correlations with influencing factors (gender, age, study year, educational attainment of the parents, urban/rural origin, ethnicity, personal experiences with mental disorders) were also explored. An online survey, using a 30-item Vietnamese version of the Mental Health Literacy Scale (MHLS), was conducted at six university sites in Vietnam and Cambodia. Data of 1032 students from different study branches were included. The MHL of Vietnamese and Cambodian university students was lower, compared to samples from Australia or the UK. Females and students with a personal experience of mental disorders (self or family) showed a significantly higher MHL. No differences in MHL were found between students from different socioeconomic backgrounds (professional attainment of parents, urban/rural origin). Findings on the influence of ethnicity were inconclusive. MHL needs to be improved among the university students of Vietnam and Cambodia. Mental health promotion should specifically target male students, students from STEM branches, and international students. 相似文献
90.