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991.
Conclusion Nasal sCT is a safe drug with few and mild side effects and compared with HRT is often more attractive to elderly, osteoporotic women. Under controlled conditions, nasal sCT reduces the rate of new fractures by two-thirds compared with calcium treatment alone [10] and increases spinal bone mass dose dependently.Conclusively, nasal sCT is indicated for treating women who have passed the menopause some years ago. The treatment should be administered discontinuously. The nasal formulation has been approved for treatment of osteoporosis in a variety of European and South American countries, and has also been filed with appropriate governmental authorities for consideration of approval in many countries throughout the world, including the US. Should calcitonin treatment be generalized in women who are 10–15 years postmenopausal, the costs will undoubtedly be reduced. Compared with the effect of HRT on early postmenopausal bone loss, the effect of nasal sCT is only marginal. Thus, HRT prevents both the cortical and trabecular bone loss throughout the entire treatment period [38]. Furthermore, HRT is inexpensive and its adverse event profile has been fully clarified except in respect to the possible change in the risk of breast cancer [39]. Nasal sCT can be effective in women soon after the menopause—by decreasing the rate of vertebral bone loss and lowering the bone turnover—as an alternative to hormone replacement therapy either when estrogens are contraindicated or for women who are not candidates for estrogen therapy. 相似文献
992.
Stereological quantitation of human brains from normal and schizophrenic individuals 总被引:2,自引:0,他引:2
Bente Pakkenberg 《Acta neurologica Scandinavica》1992,85(S137):20-33
The complex organization and high density of nerve cells in the human brain presents a challenge to the estimation of total cell numbers. The first unbiased counting method, the disector, was described in 1984 and has since made it possible to accurately count total neuron numbers in any region that can be defined, while excluding artifacts of earlier counting methods. The disector method has been applied to normal neocortex and to four subcortical brain regions from schizophrenics and controls. The total neuron number in neocortex in 26 normal individuals was estimated to be 25·109 . A 40 and 50% reduction of total nerve cell number was found in the mediodorsal thalamic nucleus and nucleus accumbens in schizophrenics, respectively. Furthermore, the Cavalieri principle has been used to estimate the volume of human cortex, white matter, central grey regions and the volume of the ventricular system in both controls and schizophrenics. As shown by these studies, the introduction of unbiased stereological methods and subsequent modifications in recent years have made it possible to estimate a number of parameters in the human brain without the biases included in most classical works. By comparison, earlier conventional counting methods have been relatively time consuming, mostly biased to a smaller or larger degree, and generally less precise. The application of these new neurostereological methods will undoubtedly provide greater confidence for future brain studies. 相似文献
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Kerstin Helander Bente Kirkhus Olav Hilmar Iversen Sonny L. Johansson Stig Nilsson Sigmund Vaage Helle Fjordvang 《Virchows Archiv : an international journal of pathology》1985,408(2-3):117-126
Summary Biopsies from 28 patients with urinary bladder carcinoma were investigated by flow cytometry and morphometry. Histopathological grading on 1.5 µm thick glycol methacrylate sections was also performed.Nuclear profile areas, nuclear volume densities and mitotic indices were usually larger in the higher grades of malignancy. All grade I tumours were diploid and all grade III tumours were aneuploid. Out of 13 grade II tumours 8 were diploid and 5 aneuploid. In these latter five cases nuclear profile areas were at the high end of the spectrum.The data show that flow cytometry and morphometry could be a valuable tool in the diagnosis of urinary bladder carcinoma. Our data also suggest that a subdivision of the grade II tumours might be possible and meaningful in the assessment of prognosis. 相似文献
997.
Nadal Ernest Horinouchi Hidehito Shih Jin-Yuan Nakagawa Kazuhiko Reck Martin Garon Edward B. Wei Yu-Feng Kollmeier Jens Frimodt-Moller Bente Barrett Emily Lipkovich Olga Visseren-Grul Carla Novello Silvia 《Drug safety》2022,45(1):45-64
Drug Safety - RELAY was a global, double-blind, placebo-controlled phase III study that demonstrated superior progression-free survival (PFS) for ramucirumab plus erlotinib (RAM + ERL) versus... 相似文献
998.
Bente Hamnes Andrew Garratt Ingvild Kjeken Elizabeth Kristjansson Kåre B Hagen 《BMC musculoskeletal disorders》2010,11(1):21
Background
The Effective Musculoskeletal Consumer Scale (EC-17) is a self-administered questionnaire for evaluating self-management interventions that empower and educate people with rheumatic conditions. The aim of the study was to translate and evaluate the Norwegian version of EC-17 against the necessary criteria for a patient-reported outcome measure, including responsiveness to change. 相似文献999.
Impact of Physical Inactivity on Subcutaneous Adipose Tissue Metabolism in Healthy Young Male Offspring of Patients With Type 2 Diabetes 总被引:1,自引:0,他引:1
Lise H?jbjerre Mette Paulli Sonne Amra Ciric Alibegovic Flemming Dela Allan Vaag Jens Bruun Meldgaard Karl Bang Christensen Bente Stallknecht 《Diabetes》2010,59(11):2790-2798