Management of partial and non-responding cutaneous squamous cell carcinoma

Cutaneous squamous cell carcinoma (cSCC) and basal cell carcinoma are the most common types of skin cancer. For patients with locally advanced and metastatic cSCC, the programmed cell death 1 (PD-1) inhibitor cemiplimab is approved for systemic treatment. Despite this revolutionary immunomodulatory therapeutic approach, tumours may fail to respond either completely or partially. In addition to the previously established local treatment with radiotherapy or systemic treatment with chemotherapy and epidermal growth factor receptor inhibitors, ongoing trials are currently focussed on re-stimulating the antitumour immune response in patients with advanced cSCC refractory to PD-1 inhibitors. In this review, ongoing and recently finished trials with different therapeutic approaches will be discussed.     

PET/CT Imaging of NSCLC with a αvβ6 Integrin-Targeting Peptide

Molecular Imaging and Biology - Targeted therapies are regarded as promising approaches to increase 5-year survival rate of non-small cell lung cancer (NSCLC) patients. Here, we investigated the...     

Evaluation of [68Ga]Ga-DATA-TOC for imaging of neuroendocrine tumours: comparison with [68Ga]Ga-DOTA-NOC PET/CT

European Journal of Nuclear Medicine and Molecular Imaging - Recently, the new hybrid chelator DATA (6-amino-1,4-diazepine-triacetate) has been introduced, which has the advantage of high yield and...     

Effect of chromium supplementation on blood glucose and lipid levels in type 2 diabetes mellitus elderly patients

Intervention trials have shown the beneficial effects of chromium supplementation in type 2 diabetes (non-insulin-dependent diabetes mellitus). This study investigated the effects of chromium picolinate on elderly diabetic patients within a rehabilitation program. Thirty-nine diabetic subjects, average age 73 years (18 males and 21 females), undergoing rehabilitation following stroke or hip fracture, were recruited to participate in this study. An additional 39 diabetic patients constituted the control group. Along with standard treatment for diabetes, the study group received 200 microg of chromium twice a day for a three-week period. Blood samples, dietary intake, and anthropometric data were collected prior to and post-intervention. Throughout the study period, participants received a diet of approximately 1500 kcal/day. Significant differences in the fasting blood level of glucose compared to the baseline (190 mg/dL vs 150 mg/dL, p < 0.001) were found at the end of the study. HbA1c also improved from 8.2% to 7.6% (p < 0.01). Total cholesterol was also reduced from 235 mg/dL to 213 mg/dL (p < 0.02). A trend towards lowered triglyceride levels was also observed (152 mg/dL vs 136 mg/dL). We conclude that, in this population of elderly, diabetic patients undergoing rehabilitation, dietary supplementation with chromium is beneficial in moderating glucose intolerance. In addition, chromium intake appears to lower plasma lipid levels.     

Gait analysis in ankle osteoarthritis and total ankle replacement

BACKGROUND: Little information is available about gait changes in ankle osteoarthritis and total ankle replacement, and also about total ankle replacement patients' rehabilitation in the first year after surgery. METHODS: Thirty subjects were included in this study: 15 unilateral post-traumatic ankle osteoarthritis patients and 15 age-/gender-matched control subjects. Patients were followed prospectively: preoperatively, at 3, 6, 9, and 12 months after total ankle replacement. The clinical-functional level was assessed by the American Orthopaedic Foot and Ankle Society ankle and the Short-Form-36 health survey score. 3D ankle-hindfoot kinematic-kinetic analysis was performed using a motion analysis and a two-plate force-platform system. Statistics included repeated measures analysis of variances, independent sample and paired Student's t-tests (significance alpha=0.05). FINDINGS: Compared to normal subjects, ankle osteoarthritis caused significant reduction of the American Orthopaedic Foot and Ankle Society and Short-Form-36 score. In gait analysis, ankle osteoarthritis showed a significant deficiency in six of seven spatiotemporal variables, a decrease of the tri-planar ankle movement, a decrease of the second active maximal vertical and the maximal medial ground reaction force, a reduction of the sagittal and transverse ankle joint moments, a reduction of the ankle joint power. Three months after total ankle replacement surgery patients experienced a worsening of gait. At 12 months follow-up, all spatiotemporal variables were not different from the normal subjects (full rehabilitation); in six of 11 kinematic and kinetic variables there was a partial rehabilitation. INTERPRETATION: This study provides data for the clinical-biomechanical understanding of the normal, arthritic, and total ankle replacement treated ankle during walking and the first year of rehabilitation.     

Problem-solving and distress in prostate cancer patients and their spousal caregivers

Goals of work Prostate cancer, the most common life-threatening cancer among American men, increases risk of psychosocial distress and negatively impacts quality of life for both patients and their spouses. To date, most studies have examined the relationship between patient coping and distress; however, it is also likely that what the spouse does to cope, and ultimately how the spouse adjusts, will affect the patients adjustment and quality of life. The present study examined the relationships of spouse problem-solving coping, distress levels and patient distress in the context of prostate cancer. The following mediational model was tested: Spouses problem-solving coping will be significantly inversely related to patients levels of distress, but this relationship will be mediated by spouses distress levels.Patients and methods One hundred seventy-one patients with prostate cancer and their spousal caregivers were assessed for mood; spouses were assessed for problem-solving coping skills. Structural equation modeling was used to test model fit.Main results The model tested was a good fit to the data. Dysfunctional spousal problem-solving was a significant predictor of spouse distress level but constructive problem-solving was not. Spouse distress was significantly related to patient distress. Spouse dysfunctional problem-solving predicted patient distress, but this relationship was mediated by spouse distress. The same mediational relationship did not hold true for constructive problem-solving.Conclusions Spouse distress mediates the relationship between spouse dysfunctional coping and patient distress. Problem-solving interventions and supportive care for spouses of men with prostate cancer may impact not only spouses but the patients as well.     

Copy number variation analysis and methylome profiling of a GNAQ-mutant primary meningeal melanocytic tumor and its liver metastasis

Primary meningeal melanocytic tumors have genetic similarities with uveal melanomas, including GNAQ or GNA11 mutations. While BAP1 mutations and loss of chromosome 3 have adverse prognostic meaning in uveal melanoma, genetic alterations associated with metastasis have not been investigated in primary meningeal melanocytic tumors. We describe a 43-year-old female with a GNAQ-mutated, BAP1-wt melanocytic tumor originating in the parietal brain region and liver metastases 4 years after initial diagnosis. After repeated surgery and chemotherapy she was treated with the immunomodulatory agent ipilimumab. Tissue from the primary and recurrent intracranial tumor (histologically originally diagnosed as intermediate-grade melanocytoma resp. melanoma) and from the liver metastasis was investigated for genome-wide copy number variations and DNA methylation profile. Complete loss of 10p and 19p, partial loss of 16p and a small deletion on 10q were only present in the liver metastasis and not in the intracranial tumors. The DNA methylation profiles of the intracranial tumors and the liver metastasis resembled those of meningeal melanocytomas. In conclusion, in this report we show that a distant metastasis of a meningeal melanocytic tumor has a similar methylation profile as the primary tumor and suggest that particular copy number variations may be associated with metastatic behavior.