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991.
992.
Vezzosi D Bennet A Rochaix P Courbon F Selves J Pradere B Buscail L Susini C Caron P 《European journal of endocrinology / European Federation of Endocrine Societies》2005,152(5):757-767
OBJECTIVE: We studied the efficacy of octreotide treatment on hypoglycaemia in patients with insulinoma and its relationships with Octreoscan scintigraphy and the presence of tumoral somatostatin receptors sst2A and sst5. DESIGN AND METHODS: 17 patients with insulinoma were evaluated using (i) evaluation of blood glucose, insulin and C-peptide during a short 100 mug octreotide test in fasting patients and/or treatment over 8 days-8 months with octreotide, (ii) Octreoscan scintigraphy and (iii) immunostaining of the tumor with anti-sst2A and anti-sst5. RESULTS: Octreotide was effective on hypoglycaemia in 10/17 patients. Octreoscan scintigraphy detected 4/17 insulinomas. sst2A receptor was detected in 7/17 insulinomas and sst5 in 15/17 insulinomas. Octreotide was effective on hypoglycaemia in those seven patients with sst2A receptor-expressing insulinoma, and in three patients with undetectable sst2A receptor and detectable sst5; it was ineffective in six patients whose tumor expressed the sst5 receptor with undetectable sst2A and in one patient with undetectable sst2A and sst5 receptor. CONCLUSIONS: Octreotide is an effective treatment of hypoglycaemia in more than 50% of patients with insulinoma. Detection of responsive patients was better based on a positive short test with subcutaneous octreotide than on the results of Octreoscan scintigraphy. Positive anti-sst2 receptor immunostaining is associated with efficacy of octreotide treatment, but does not account for all cases of responsiveness to octreotide. Expression of sst5 receptor does not appear to explain per se the efficacy of octreotide on sst2A-negative insulinomas. 相似文献
993.
McMurtry I Bennet GC Bradish C 《The Journal of bone and joint surgery. British volume》2005,87(7):986-989
We report 12 consecutive cases of vertical scapular osteotomy to correct Sprengel's deformity, performed during a 16-year period, with a mean follow-up of 10.4 years. The mean increase in abduction of the shoulder was 53 degrees . The cosmetic appearance improved by a mean of 1.5 levels on the Cavendish scale. Neither function nor cosmesis deteriorated with time. We recommend the procedure for correction of moderate deformities with a functional deficit. 相似文献
994.
Omalu BI DeKosky ST Minster RL Kamboh MI Hamilton RL Wecht CH 《Neurosurgery》2005,57(1):128-34; discussion 128-34
995.
Ferrari V Valcamonico F Amoroso V Simoncini E Vassalli L Marpicati P Rangoni G Grisanti S Tiberio GA Nodari F Strina C Marini G 《Cancer chemotherapy and pharmacology》2006,57(2):185-190
Introduction: Single agent gemcitabine (GEM) is the standard treatment of pancreatic adenocarcinoma. Celecoxib is a selective cyclooxygenase-2
(COX-2) inhibitor. Recent studies in human pancreatic tumor cell lines suggest an involvement of COX-2 in tumor-dependent
angiogenesis and provide the rational for inhibition of the COX pathway as an effective therapeutic approach. The aim of this
study is to evaluate the toxicity and activity of gemcitabine plus celecoxib. Patients and methods: Forty-two consecutive patients with histologically or cytologically confirmed pancreatic adenocarcinoma entered the trial.
Twenty-six patients (pts) were metastatic, 16 pts had locally advanced disease. The schedule consisted of GEM 1,000 mg/m2 (as a 30 min iv infusion) on days 1, 8 every 3 weeks and celecoxib 400 mg bid. Results: Four pts (9%) achieved a partial response and 26 (62%) had stable disease, gaining a total disease control in 30 pts (71%
[95% CI, 58–84%]). Overall clinical benefit response was experienced by 23 pts (54.7% [95%CI, 38.6–70.1%]). Neither grade
4 neutropenia nor grade 3–4 thrombocytopenia was observed. Grade 3 neutropenia was detected in 19% of pts. Grade 3 non-hematological
toxicity was as follows: hepatic toxicity 7%, nausea 2.3%. Three pts (7%) and 5 pts (12%) had respectively a minimum creatinine
increase and edema. Median survival was 9.1 months (95% CI, 7.5–10.6 months). Conclusion: GEM in combination with celecoxib showed low toxicity, good clinical benefit rate and good disease control. Further clinical
investigation is warranted. 相似文献
996.
997.
APA微囊猪肝细胞移植治疗大鼠急性肝功能衰竭的实验研究 总被引:3,自引:1,他引:3
目的探讨APA微囊猪肝细胞移植治疗大鼠急性肝功能衰竭的有效性。方法用胶原酶灌注分离猪肝细胞,用海藻酸钠-聚赖氨酸-海藻酸钠(alginate-polylysine-alginate,APA)包埋肝细胞,测定肝细胞产量和存活率。用氨基半乳糖诱导建立大鼠急性肝功能衰竭(fulminatehepaticfailure,FHF)模型(n=68),实验动物分为微囊肝细胞植入组、游离肝细胞植入组、空囊组、对照组4组。分别将微囊肝细胞、游离肝细胞、空微囊、生理盐水植入或注入FHF大鼠腹腔,观察治疗效果。结果分离肝细胞产量为1.74×1010~2.90×1010个,微囊肝细胞存活率>80%。APA微囊肝细胞组与游离肝细胞、空囊和对照组相比,能提高FHF大鼠存活率,延长存活时间,改善肝功能。结论APA微囊猪肝细胞腹腔移植治疗FHF大鼠有较好疗效。ExperimentalStudyonHepaticFailureRatInstitute,Tianjin300170AbstractObjectiveThepaticfailurerat.Methpolylysine-alginate(APA(FHF)ratsweresetup 相似文献
998.
999.
Ischemia in isolated interventricular septa: mechanical events 总被引:2,自引:0,他引:2
1000.
Positional cloning of a gene involved in hereditary multiple exostoses 总被引:21,自引:1,他引:21
Wuyts W; Van Hul W; Wauters J; Nemtsova M; Reyniers E; Van Hul EV; De Boulle K; de Vries BB; Hendrickx J; Herrygers I; Bossuyt P; Balemans W; Fransen E; Vits L; Coucke P; Nowak NJ; Shows TB; Mallet L; van den Ouweland AM; McGaughran J; Halley DJ; Willems PJ 《Human molecular genetics》1996,5(10):1547-1557
Hereditary multiple exostosis (EXT) is an autosomal dominant condition
mainly characterized by the presence of multiple exostoses on the long
bones. These exostoses are benign cartilaginous tumors (enchondromata).
Three different EXT loci on chromosomes 8q (EXT1), 11p (EXT2) and 19p
(EXT3) have been reported, and recently the EXT1 gene was identified by
positional cloning. To isolate the EXT2 gene, we constructed a contig of
yeast artificial chromosomes (YAC) and P1 clones covering the complete EXT2
candidate region on chromosome 11p11-p12. One of the transcribed sequences
isolated from this region corresponds to a novel gene with homology to the
EXT1 gene, and harbours inactivating mutations in different patients with
hereditary multiple exostoses. This indicates that this gene is the EXT2
gene. EXT2 has an open reading frame encoding 718 amino acids with an
overall homology of 30.9% with EXT1, suggesting that a family of related
genes might be responsible for the development of EXT.
相似文献