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排序方式: 共有6650条查询结果,搜索用时 15 毫秒
61.
62.
Hernández-Díaz Yazmín González-Castro Thelma Beatriz Tovilla-Zárate Carlos Alfonso López-Narváez María Lilia Genis-Mendoza Alma Delia Castillo-Avila Rosa Giannina Ramos-Méndez Miguel Ángel Juárez-Rojop Isela Esther 《Metabolic brain disease》2021,36(8):2415-2424
Metabolic Brain Disease - Schizophrenia is a debilitating mental illness. Levels of oxytocin have been proposed as a biomarker of schizophrenia; however, the observed levels of oxytocin in... 相似文献
63.
Mitoxantrone, a topoisomerase II inhibitor, induces apoptosis of B-chronic lymphocytic leukaemia cells 总被引:1,自引:0,他引:1
Beatriz Bellosillo Dolors Colomer Gabriel Pons & Joan Gil 《British journal of haematology》1998,100(1):142-146
B-chronic lymphocytic leukaemia (B-CLL) is characterized by the accumulation of long-lived CD5+ B lymphocytes. The effect of mitoxantrone, a topoisomerase II inhibitor, on B-CLL cells was studied. Treatment of B-CLL cells for 48 h with mitoxantrone (0.5 μg/ml) induced a decrease in cell viability as determined by MTT assay. The IC50 calculated for the cells of three patients was 0.7 μg/ml for two of them and 1.4 μg/ml for the third. In all three patients the maximum effect was observed with 2 μg/ml. An additive cytotoxic effect was observed when mitoxantrone (0.5 μg/ml) was combined with fludarabine (5 μg/ml). Mitoxantrone induced DNA fragmentation and the proteolytic cleavage of poly(ADP-ribose) polymerase (PARP), a marker of the activation of caspases, in all the patients studied, demonstrating that the cytotoxic effect of mitoxantrone was due to induction of apoptosis. These results suggest that mitoxantrone, and possibly other topoisomerase II inhibitors, may be used in the chemotherapy of B-CLL, and that combination of mitoxantrone with fludarabine or other drugs could improve the effectiveness of the treatment. 相似文献
64.
Rivas P Górgolas M Gimena B Sousa J Fernández-Guerrero ML 《Scandinavian journal of infectious diseases》2005,37(5):373-374
We present a 68-y-old female who had undergone aortocoronary bypass and developed Staphylococcus aureus sternal osteomyelitis. Despite prolonged therapy with different antibiotics and several local debridements and drainage, the wound remained open and suppurative. Only after sternectomy and wide excision of infected costal cartilage was the diagnosis of sternal tuberculosis made, 24 months later. This case illustrates the necessity of a high degree of suspicion to diagnose this very rare entity which coexists with more common causes of sternal osteomyelitis. 相似文献
65.
Yujuan Wang Beatriz E. Marciano Defen Shen Rachel J. Bishop Stanley Park Steven M. Holland Chi-Chao Chan 《Journal of clinical immunology》2013,33(5):917-924
Purpose
Chronic granulomatous disease (CGD) is an inherited disorder characterized by defects in phagocyte-derived nicotinamide adenine dinucleotide phosphate oxidase. It is typically diagnosed in childhood and leads to severe, recurrent bacterial or fungal infections. Chorioretinal lesions are the most common ocular manifestation. We sought to determine whether there are infectious agents in CGD-associated chorioretinopathy.Methods
Medical records and ocular histopathology from CGD cases from January 1983 to January 2012 at the National Institutes of Health were retrospectively reviewed. Chorioretinal cells from normal and lesional tissues of the same eye were microdissected. Primers for Staphylococcus epidermidis, Staphylococcus aureus, Pseudomonas aeruginosa, Burkholderia sp., and a panbacterial 16S ribosomal DNA were used for polymerase chain reaction.Results
Seventeen CGD patients had ocular tissues (16 autopsied cases and 1 chorioretinal biopsy) examined. Of these 17, 8 demonstrated CGD-associated chorioretinal lesions in at least one eye on histopathology. Of these 8, 7 showed amplification of 16S ribosomal DNA within the lesion; of these 7, two also amplified S. epidermidis and one P. aeruginosa. One had no bacterial DNA amplified. Importantly, no microbial DNA was amplified from the normal, non-lesional ocular tissues of these 8 cases. Furthermore, only 1 of the 9 eyes without chorioretinopathy had amplified Burkholderia DNA, that patient had a history of Burkholderia infection.Conclusions
We detected bacterial DNA in 7 of 8 (88 %) cases with CGD-associated chorioretinopathy and only in 1 normal ocular tissue of 17 CGD cases. Bacterial infection may play a role in the pathogenesis of CGD-associated chorioretinal lesions. 相似文献66.
Navas-Sánchez Francisco J. Fernández-Pena Alberto Martín de Blas Daniel Alemán-Gómez Yasser Marcos-Vidal Luís Guzmán-de-Villoria Juan A. Fernández-García Pilar Romero Julia Catalina Irene Lillo Laura Muñoz-Blanco José L. Ordoñez-Ugalde Andrés Quintáns Beatriz Pardo Julio Sobrido María-Jesús Carmona Susanna Grandas Francisco Desco Manuel 《Journal of neurology》2021,268(7):2429-2440
Journal of Neurology - SPG4 is an autosomal dominant pure form of hereditary spastic paraplegia (HSP) caused by mutations in the SPAST gene. HSP is considered an upper motor neuron disorder... 相似文献
67.
Ane Murueta‐Goyena Rocío Del Pino Marta Galds Begoa Arana Marian Acera Mar Carmona‐Abelln Tamara Fernndez‐Valle Beatriz Tijero Olaia Lucas‐Jimnez Natalia Ojeda Naroa Ibarretxe‐Bilbao Javier Pea Jesus Cortes Unai Ayala Maitane Barrenechea Juan Carlos Gmez‐Esteban Iigo Gabilondo 《Annals of neurology》2021,89(1):165-176
68.
Luis Velázquez-Pérez DSc Roberto Rodriguez-Labrada PhD Yasmani González-Garcés BSc Eduardo Arrufat-Pie MD Reidenis Torres-Vega BSc Jacqueline Medrano-Montero PhD Beatriz Ramirez-Bautista MD Yaimeé Vazquez-Mojena MSc Georg Auburger MD Fay Horak PhD Ulf Ziemann PhD Christopher M. Gomez PhD 《Movement disorders》2021,36(2):471-480
69.
Braz Aline Mrcia Marques Winckler Fernanda Cristina Binelli Larissa Sarri Chimeno Luis Guilherme Lopes Lia Beatriz Mantovani Lima Rodrigo Santos Simes Rafael Plana Grotto Rejane Maria Tommasini Golim Marjorie de Assis Silva Giovanni Faria 《Clinical and experimental medicine》2021,21(4):587-597
Clinical and Experimental Medicine - Cirrhotic patients with chronic hepatitis C should be monitored for the evaluation of liver function and screening of hepatocellular carcinoma even after... 相似文献
70.
Takahama Jr Ademar de Sousa Vitoria Iaros Tanaka Elisa Emi Ono Evelise Ito Fernanda Akemi Nakanishi Costa Priscila Paganini Pedriali Maria Beatriz Bergonse Pereira de Lima Heliton Gustavo Fornazieri Marco Aurélio Correia Leticia Sassaki Cardoso Lucienne Tibery Queiroz de Maio Carrilho Claudia Maria Dantas 《Clinical oral investigations》2021,25(3):1217-1222
Clinical Oral Investigations - This a cross-sectional study to evaluate the association between oral health findings and ventilator-associated pneumonia (VAP) among critically ill patients in... 相似文献